Results 71 to 80 of about 98,427 (296)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

4-H Youth Development: The Past, the Present, and the Future

Journal of Extension, 2014
The 4-H Program within Cooperative Extension is more than 100 years old. As we celebrate 100 years of Cooperative Extension, the foundation built by the 4-H Program serves as grounds to meet the needs of today's youth.
L. Borden, D. Perkins, Kyle R. Hawkey
semanticscholar   +1 more source

Impact of COVID-19 on Missouri 4-H State Fair Participation and Implications for Youth Development Programs

Journal of Extension, 2020
For University of Missouri Extension, facilitation of Missouri 4-H's participation in the Missouri State Fair (MSF) during the COVID-19 era was a challenge and an opportunity for improvement. In a time when positive youth development experiences are more necessary than ever, Extension professionals must consider how to uphold the foundations of ...
Calvert, Maria L., Fabregas Janeiro, Maria G.   +1 more
openaire   +2 more sources

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Youth in 4-H Latino Initiative programs achieve similar outcomes to youth in 4-H community clubs

California Agriculture, 2019
Until recently, California 4-H programs did not represent the ethnic diversity found in California's population of young people. To close the gap in representation — particularly with Latino youth — UC ANR began the 4-H Latino Initiative, an effort to ...
Steven Worker, Maria Fábregas Janeiro, Kendra Lewis   +2 more
doaj   +2 more sources

Risk Management for 4-H Youth Development Work: Basic Building Blocks for All

EDIS, 2010
4H10.2, a 3-page fact sheet by Dale Pracht, Marilyn Norman, Kate Fogarty, and Jean Hink, is part of the Risk Management for 4-H Youth Development Work series.
Dale Pracht, Marilyn Norman, Kate Fogarty, Jean Hink   +3 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Risk Management for 4-H Youth Development Work: Special Events and Activities

EDIS, 2010
4H10.3, a 4-page fact sheet by Dale Pracht, Marilyn Norman, Kate Fogarty, and Jean Hink, is part of the Risk Management for 4-H Youth Development Work series. It describes ways to prepare for risks when 4-H has special events like fairs, conferences, and
Dale Pracht, Marilyn Norman, Kate Fogarty, Jean Hink   +3 more
doaj   +1 more source

Minnesota 4-H Science of Agriculture Challenge: Infusing Agricultural Science and Engineering Concepts into 4-H Youth Development

Journal of Extension, 2016
Youth involved in 4-H projects have been engaged in science-related endeavors for years. Since 2006, 4-H has invested considerable resources in the advancement of science learning. The new Minnesota 4-H Science of Agriculture Challenge program challenges
Joshua Rice, B. Rugg, S. Davis
semanticscholar   +1 more source