Results 151 to 160 of about 3,073 (165)

Novel 1, 2, 4-oxadiazoles as potent and selective histamine H3 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 1996
Abstract Replacement of the isothiourea moiety of known histamine H 3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, 3-[(4-chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-oxadiazole (GR175737) is a potent, selective, orally active and centally penetrating H 3 ...
J.W. Clitherow, P. Beswick, W.J. Irving, D.I.C. Scopes, J.C. Barnes, J. Clapham, J.D. Brown, D.J. Evans, A.G. Hayes   +8 more
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Design, Synthesis and Anti Cancer Evaluation of novel 1, 3, 4-oxadiazoles

Research Journal of Pharmacy and Technology
We designed and synthesized newer heterocyclic compounds with 1, 3, 4-thiadiazole, pyrimidine, and 1, 3, 4 -oxadiazole, with aimed to develop Histone Deacetylase (HDAC) inhibitors. The 1, 3, 4 - oxadiazole nucleus known for its diverse pharmacological properties and incorporating the thiadiazole and pyrimidine groups.
Meghna H. Seta, Monika T. Kyada
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ChemInform Abstract: Synthesis of Substituted 2‐(1′,3′,4′‐Oxadiazol‐2′‐yl)indoles.

Chemischer Informationsdienst, 1986
AbstractAseries of title compounds of type (IV), (VII) and (IX) is synthesized starting from the hydrazides (I).
K. H. SINNUR, S. SIDDAPPA, S. P. HIREMATH, M. G. PUROHIT   +3 more
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The preparation of 1, 3, 4-oxadiazoles

Chemistry of Heterocyclic Compounds, 1970
Ya. A. Levin, M. S. Skorobogatova
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1, 3, 4-Oxadiazole: A Versatile Compound With Potent Analgesic Activity

Oxadiazole is a heterocyclic ring with 5 members that has 1 oxygen atom, 2 nitrogen atoms, 2 double bonds, and 2 carbons. In furan, they are created by placing two methylene groups (=CH) for two nitrogen (-N=) atoms. The aromaticity was reduced by the substitution of these groups. There were four different isomer of oxadiazole that were identified: 1,3,
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5‐(1‐Alkenyl)‐1, 3, 4‐oxadiazol‐2(3H)‐one

Helvetica Chimica Acta, 1974
Abstract3‐(2‐alkenoyl)‐thiocarbazic acid O‐methyl esters 1 are desulfurated by bromine and the unknown intermediates are transformed by alkali to 5‐(1‐alkenyl)‐1, 3, 4‐oxadiazol‐2(3H)‐ones (2). This type of oxadiazolone substitution is not realizable by the common ring closure of hydrazides with phosgene due to pyrazolidinone ring closure of ...
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Microwave spectra of isotopic 1, 3, 4-oxadiazoles

Journal of Molecular Structure, 1972
Lise Nygaard, Rasmus Lykke Hansen, Jørgen Tormod Noelsen, John Rastrup-Andersen, O.Ole Sørensen, P.Alston Steiner   +5 more
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Microwave reactions of 2, 5-bis-trifluoromethyl-1, 3, 4-oxadiazole with norbornenes

2009
The reactions of 2, 5-bis-trifluoromethyl-1, 3, 4- oxadiazole 2 with norbornenes [1] under microwave conditions were investigated. MW reactions enabled the reaction times and temperatures to be significantly reduced, as compared to classical thermal reactions.
Margetić, Davor, Trošelj, Pavle, Marinić, Željko   +2 more
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Aromatic poly(amide‐hydrazides) and poly(amide‐1,3‐4‐oxadiazoles)

Journal of Polymer Science Part B: Polymer Letters, 1967
Bill M. Culbertson, Rosemary Murphy
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The synthesis of 1 : 2 : 4-oxadiazoles

Journal of the Chemical Society (Resumed), 1954
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