Results 141 to 150 of about 2,991 (181)
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1976
Publisher Summary This chapter focuses on the chemistry of 1,2,4-oxadiazoles and the corresponding reduced derivatives. The chapter discusses the synthesis of 1,2,4-oxadiazoles. Two widely used general methods of synthesizing 1,2,4-oxadiazoles embrace 95% of the practical preparations of these compounds: The conversion of amidoximes by means of ...
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Publisher Summary This chapter focuses on the chemistry of 1,2,4-oxadiazoles and the corresponding reduced derivatives. The chapter discusses the synthesis of 1,2,4-oxadiazoles. Two widely used general methods of synthesizing 1,2,4-oxadiazoles embrace 95% of the practical preparations of these compounds: The conversion of amidoximes by means of ...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME NEW 1, 3, 4-OXADIAZOLES
INDIAN DRUGS, 2012Various 5-β-[(N-Benzenesulphonyl/tosyl)-4-(un) substituted anilino] ethyl-2-H/CH3/C6H5/-CH2C6H5/p-NO2C6H4-1,3,4-oxadiazoles (5a-d), 5--β-[(N-Benzenesulphonyl/tosyl)-4-(un)-substituted anilino] ethyl-2-(N,N-diethylamino/anilino/morpholino)-1, 3, 4-oxadiazoles (6a-r), 3--β-[(N-Benzenesulphonyl/tosyl)-4-(un) substituted anilino] ethyl-4-amino-5-mercapto-4(
S Desai, U. Laddi
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Investigation of 1, 3, 4-Oxadiazole Scaffold as Potentially Active Compounds
International Journal of Drug Design and Discovery, 2011In the present work, various Schiff’s bases of isoniazid bearing 1, 3, 4-oxadiazole nucleus were synthesized. These compounds were purified, characterized and evaluated in vitro for antibacterial, antifungal and antiviral activities. Compound 5 showed better biological profile.
Rakesh R. Somani +4 more
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Synthesis and biological evaluation of 1, 2, 4‐oxadiazole derivatives as novel GPR119 agonists
Chemical Biology & Drug Design, 2016A series of 1, 2, 4‐oxadiazole derivatives have been designed and synthesized, and 25 compounds were evaluated their abilities by the assay of cAMP concentration in GPR119‐transfected HEK293T cells. All compounds showed acceptable agonistic effects on GPR119. Among these compounds, 4p exhibited the best agonistic effects with the EC50 of 20.6 nm, which
Suhong, Fu +4 more
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Synthesis of Some New 1, 3, 4-Oxadiazole, Pyrazole, and Pyrimidine Bearing Thienopyrazole Moieties
Current Organic Synthesis, 2020Aim and Objective: According to the literature survey, pyrazole is a unique template that is associated with several biological activities. This article highlighted the research work of many researchers reported in the literature for synthesis and different pharmacological activities of the pyrazole nucleus.
Mohamed Ahmed Elian Sophy +1 more
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Synthesis of arylethylene derivatives of 2, 5-diphenyl-1, 3, 4-oxadiazole
Chemistry of Heterocyclic Compounds, 1971The synthesis of arylethylene derivatives of 2,5-diphenyl-1,3,4-oxadiazole by the Wittig reaction from 2-(p-bromomethylphenyl)-5-phenyl-1,3,4-oxadiazole and aromatic aldehydes is described. The compounds obtained fluoresce strongly on irradiation with UV light.
B. M. Krasovitskii, V. I. Grigor'eva
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Anti-inflammatory and Antimicrobial Potential of 1, 3, 4-oxadiazoles and its Derivatives: A Review
Current Organic SynthesisAbstract: 1, 3, 4-oxadiazole and its derivatives have significant anti-inflammatory and antimicrobial property. Their precise mechanism of action is not known but it is postulated that they act by inhibiting the biosynthesis of certain prostaglandins.
Tarun, Chaudhary +2 more
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The preparation of 1, 3, 4-oxadiazoles
Chemistry of Heterocyclic Compounds, 1970Ya. A. Levin, M. S. Skorobogatova
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Design, Synthesis and Anti Cancer Evaluation of novel 1, 3, 4-oxadiazoles
Research Journal of Pharmacy and TechnologyWe designed and synthesized newer heterocyclic compounds with 1, 3, 4-thiadiazole, pyrimidine, and 1, 3, 4 -oxadiazole, with aimed to develop Histone Deacetylase (HDAC) inhibitors. The 1, 3, 4 - oxadiazole nucleus known for its diverse pharmacological properties and incorporating the thiadiazole and pyrimidine groups.
Meghna H. Seta, Monika T. Kyada
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Microwave spectra of isotopic 1, 3, 4-oxadiazoles
Journal of Molecular Structure, 1972Lise Nygaard +5 more
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