Pyrazoles and Pyrazolines as Anti-Inflammatory Agents [PDF]
Molecules, 2021 The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities.
Eleni Pontiki +1 more
exaly +5 more sources
Trifluoromethylated hydrazones and acylhydrazones as potent nitrogen-containing fluorinated building blocks [PDF]
Beilstein Journal of Organic Chemistry, 2023 Nitrogen-containing organofluorine derivatives, which are prepared using fluorinated building blocks, are among the most important active fragments in various pharmaceutical and agrochemical products. This review focuses on the reactivity, synthesis, and
Zhang Dongxu
doaj +2 more sources
Antinociceptive effect of novel pyrazolines in mice [PDF]
Brazilian Journal of Medical and Biological Research, 2004 The antinociceptive effect of six novel synthetic pyrazolines (3-ethoxymethyl-5-ethoxycarbonyl-1H-pyrazole (Pz 1) and its corresponding 1-substituted methyl (Pz 2) and phenyl (Pz 3) analogues, and 3-(1-ethoxyethyl)-5-ethoxycarbonyl-1H-pyrazole (Pz 4) and
Z. Tabarelli +10 more
doaj +5 more sources
De Novo Design of Imidazopyridine-Tethered Pyrazolines That Target Phosphorylation of STAT3 in Human Breast Cancer Cells [PDF]
Bioengineering, 2023 In breast cancer (BC), STAT3 is hyperactivated. This study explored the design of imidazopyridine-tethered pyrazolines as a de novo drug strategy for inhibiting STAT3 phosphorylation in human BC cells.
Akshay Ravish +14 more
doaj +2 more sources
The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds [PDF]
MoleculesNitrogen-containing heterocycles are fundamental scaffolds in organic chemistry, particularly due to their prevalence in pharmaceuticals, agrochemicals and materials science.
Catarina M. Correia +2 more
doaj +2 more sources
Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines
Molecules, 2003 Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH2 (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under
Davood Azarifar
exaly +3 more sources
Recent advances in the therapeutic applications of pyrazolines [PDF]
Expert Opinion on Therapeutic Patents, 2012 Pyrazolines are well-known and important nitrogen-containing five-membered ring heterocyclic compounds. Various methods have been worked out for their synthesis. Several pyrazoline derivatives have been found to possess diverse biological properties, which has stimulated research activity in this field.The present review sheds light on the recent ...
Mohamed R Shaaban +2 more
exaly +3 more sources
Pyrazoline derivatives as promising novel antischistosomal agents [PDF]
Scientific Reports, 2021 Praziquantel is the only available drug to treat schistosomiasis, a parasitic disease that currently infects more than 240 million people globally. Due to increasing concerns about resistance and inadequate efficacy there is a need for new therapeutics ...
Cristiane S. Morais +9 more
doaj +2 more sources
Secosteroid–2-Pyrazoline Hybrids: Design, Synthesis, Biological Evaluation and Development of Therapeutic Combinations Against ERα-Positive Breast Cancer Cells [PDF]
BiomedicinesBackground/Objectives: Breast cancer remains one of the most prevalent and life-threatening malignancies worldwide. This study describes the design and biological evaluation of a series of secosteroid–2-pyrazoline hybrids as novel antitumor agents ...
Alexey I. Ilovaisky +13 more
doaj +2 more sources
Virtual screening of anticancer activity of chalcones and pyrazolines as potential EGFR, VEGFR, and cytochrome P450 inhibitors [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Metastatic breast cancer is still categorized as an incurable disease because all available therapies are palliative treatments to relieve symptoms and increase life expectancy.
Hesti Lina Wiraswati +9 more
doaj +1 more source