Pyrazoles and Pyrazolines as Anti-Inflammatory Agents [PDF]
Molecules, 2021 The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities.
Eleni Pontiki +2 more
exaly +5 more sources
2-Pyrazoline-5-One Derivative Suppresses Cell Proliferation and Induces Apoptosis With Upregulation of Bax in Breast Cancer Cells. [PDF]
J Biochem Mol Toxicol2‐Pyrazoline‐5‐one derivative inhibits proliferation and migration and induces Bax‐mediated apoptosis in breast cancer cells. ABSTRACT The most common cancer in women worldwide is still breast cancer. Among its subtypes, luminal A and triple‐negative breast cancers present significant therapeutic challenges due to intrinsic drug resistance and absence ...
Sevinc SK +3 more
europepmc +2 more sources
Trifluoromethylated hydrazones and acylhydrazones as potent nitrogen-containing fluorinated building blocks [PDF]
Beilstein Journal of Organic Chemistry, 2023 Nitrogen-containing organofluorine derivatives, which are prepared using fluorinated building blocks, are among the most important active fragments in various pharmaceutical and agrochemical products. This review focuses on the reactivity, synthesis, and
Zhang Dongxu
doaj +2 more sources
Synthesis of Some Novel Chalcone and 3,5‐Disubstituted Pyrazoline Derivatives: Evaluation of Their α‐Amylase and α‐Glucosidase Inhibitory Activities In Vitro and In Silico [PDF]
Arch Pharm (Weinheim)A novel pyrazoline derivative (P2) was synthesized and demonstrated potent α‐glucosidase inhibition (IC50 = 2.10 µM), significantly surpassing acarbose and highlighting its promise as an effective oral antidiabetic agent. ABSTRACT This study reports the synthesis of some novel chalcone (C1–C3) and 3,5‐disubstituted pyrazoline derivatives (P1–P3 ...
Erbay F +6 more
europepmc +2 more sources
De Novo Design of Imidazopyridine-Tethered Pyrazolines That Target Phosphorylation of STAT3 in Human Breast Cancer Cells [PDF]
Bioengineering, 2023 In breast cancer (BC), STAT3 is hyperactivated. This study explored the design of imidazopyridine-tethered pyrazolines as a de novo drug strategy for inhibiting STAT3 phosphorylation in human BC cells.
Akshay Ravish +14 more
doaj +2 more sources
Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines
Molecules, 2003 Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH2 (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under
Davood Azarifar
exaly +3 more sources
The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds [PDF]
MoleculesNitrogen-containing heterocycles are fundamental scaffolds in organic chemistry, particularly due to their prevalence in pharmaceuticals, agrochemicals and materials science.
Catarina M. Correia +2 more
doaj +2 more sources
Pyrazoline derivatives as promising novel antischistosomal agents [PDF]
Scientific Reports, 2021 Praziquantel is the only available drug to treat schistosomiasis, a parasitic disease that currently infects more than 240 million people globally. Due to increasing concerns about resistance and inadequate efficacy there is a need for new therapeutics ...
Cristiane S. Morais +9 more
doaj +2 more sources
Expeditious synthesis of 1,3,4-oxadiazole derivatives via sydnones [PDF]
Journal of the Serbian Chemical Society, 2008 The clean cyclization of chalcones (1a–c/2a–c) with hydrazine hydrate under microwave irradiation afforded pyrazolines derivatised with sydnone (3d–i/4d–i), which underwent 1,3-dipolar cyclo-addition with acetic anhydride to form pyrazolines appended ...
D. G. BHADREGOWDA +2 more
doaj +3 more sources
PYRAZOLINES WITH ANTICONVULSANT AND MAO INHIBITORY ACTIVITIES [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2014 2-Pyrazolines (4,5-dihydro-1H-pyrazole) are an important class of five-membered heterocyclic compounds and were found to be vital building block in medicinal chemistry and led to the discovery of a number of bioactive derivatives.
Mohamed Aboul-Enein
doaj +1 more source