Synthesis of Some Novel Chalcone and 3,5-Disubstituted Pyrazoline Derivatives: Evaluation of Their α-Amylase and α-Glucosidase Inhibitory Activities In Vitro and In Silico. [PDF]
Arch Pharm (Weinheim)A novel pyrazoline derivative (P2) was synthesized and demonstrated potent α‐glucosidase inhibition (IC50 = 2.10 µM), significantly surpassing acarbose and highlighting its promise as an effective oral antidiabetic agent. ABSTRACT This study reports the synthesis of some novel chalcone (C1–C3) and 3,5‐disubstituted pyrazoline derivatives (P1–P3 ...
Erbay F +6 more
europepmc +2 more sources
2-Pyrazoline-5-One Derivative Suppresses Cell Proliferation and Induces Apoptosis With Upregulation of Bax in Breast Cancer Cells. [PDF]
J Biochem Mol Toxicol2‐Pyrazoline‐5‐one derivative inhibits proliferation and migration and induces Bax‐mediated apoptosis in breast cancer cells. ABSTRACT The most common cancer in women worldwide is still breast cancer. Among its subtypes, luminal A and triple‐negative breast cancers present significant therapeutic challenges due to intrinsic drug resistance and absence ...
Sevinc SK +3 more
europepmc +2 more sources
Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity [PDF]
Journal of the Serbian Chemical Society, 2015 A series of pyrazolines 4a-g have been synthesized by Michael addition of chalcones 3a-g with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation.
Ashok Dongamanti +3 more
doaj +1 more source
Molecules, 2021 Indoles derived from both natural sources or artificial synthetic methods have been known to interact with aryl hydrocarbon receptors (AhR), and exhibit anticancer activity.
Katharigatta N. Venugopala +3 more
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Synthesis of novel pyrazoline based bis (1,2,3-triazole) scaffolds via click chemistry [PDF]
Journal of the Serbian Chemical Society, 2017 A series of novel bis(1,2,3-triazoles) derivatives 7a–m were synthesized by the 1,3-dipolar cycloaddition (click-reaction) of 1-methyl-3,5-bis(2- -(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1H-pyrazole (5) with various aralkyl azides 6a–m in the presence of ...
Kiran Kothuri +4 more
doaj +1 more source
Bulletin of Faculty of Pharmacy Cairo University, 2013 Driven by the increased demand of pyrazolines exhibiting biological activities like antioxidant, anti-inflammatory, antidepressant, antimicrobial, antitumor, and antitubercular drug activity as a stable fragment in biological moieties, lead us to ...
Akshay Kumar +2 more
doaj +1 more source
Molecules, 2021 A total of fourteen pyrazoline derivatives were synthesized through cyclo-condensation reactions by chalcone derivatives with different types of semicarbazide.
Kok Tong Wong +5 more
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Synthesis, antimicrobial and antitubercular activities of some novel pyrazoline derivatives
Journal of Saudi Chemical Society, 2016 In the present study, two new series of pyrazolines (3a–h & 4a–h) were synthesized starting from p-acetamidophenol (paracetamol) and evaluated for their antibacterial, antifungal and antitubercular activities.
Aftab Ahmad +4 more
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1-[5-(3,5-Dimethoxyphenyl)-3-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
IUCrData, 2021 In the title compound, C20H22N2O4, two benzene rings bearing methoxy substituents are connected by a central acetylpyrazoline ring: the dihedral angle between the benzene rings is 83.7 (1)°.
Miri Yoo, Dongsoo Koh
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Hybridization of Thiazole and Pyrazoline heterocycles, and the Biological Activities of Their Hybrid Scaffolds [PDF]
ERU Research JournalThiazoles and pyrazolines represent a class of heterocyclic compounds with attractive and considerable interest in medicinal chemistry due to their diverse pharmacological activities.
Mariam Fakhry, Amr Mattar
doaj +1 more source