Results 21 to 30 of about 928 (176)

Hybridization of Thiazole and Pyrazoline heterocycles, and the Biological Activities of Their Hybrid Scaffolds [PDF]

open access: yesERU Research Journal
Thiazoles and pyrazolines represent a class of heterocyclic compounds with attractive and considerable interest in medicinal chemistry due to their diverse pharmacological activities.
Mariam Fakhry, Amr Mattar
doaj   +1 more source

Design, Synthesis, and In Vitro Evaluation of Novel Indolyl DiHydropyrazole Derivatives as Potential Anticancer Agents

open access: yesMolecules, 2021
Indoles derived from both natural sources or artificial synthetic methods have been known to interact with aryl hydrocarbon receptors (AhR), and exhibit anticancer activity.
Katharigatta N. Venugopala   +3 more
doaj   +1 more source

Green Synthesis and In Vitro Biological Evaluation of Heteroaryl Chalcones and Pyrazolines of Medicinal Interest

open access: yesJournal of Chemistry, 2013
Pyrazolines are well known and important nitrogen containing 5-membered heterocyclic compounds. In the present investigation, a series of various heteroaryl chalcones and pyrazolines were synthesized by condensing formylquinolines with diverse ketones ...
Vishal Banewar
doaj   +1 more source

Synthesis of novel pyrazoline based bis (1,2,3-triazole) scaffolds via click chemistry [PDF]

open access: yesJournal of the Serbian Chemical Society, 2017
A series of novel bis(1,2,3-triazoles) derivatives 7a–m were synthesized by the 1,3-dipolar cycloaddition (click-reaction) of 1-methyl-3,5-bis(2- -(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1H-pyrazole (5) with various aralkyl azides 6a–m in the presence of ...
Kiran Kothuri   +4 more
doaj   +1 more source

Synthesis, spectral characterization and biological evaluation of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(-2-pyridyl)-4-pyrazolines via Michael addition

open access: yesJournal of Saudi Chemical Society, 2016
A series of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(2-pyridyl)-4-pyrazolines derivatives have been synthesized using sodium acetate as a catalyst. The spectral characterization and structure of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(2-pyridyl)-4-pyrazolines
D. Chinnaraja   +3 more
doaj   +1 more source

Synthesis, Characterization and Biological Evaluation of New 3,5-Disubstituted-Pyrazoline Derivatives as Potential Anti-Mycobacterium tuberculosis H37Ra Compounds

open access: yesMolecules, 2021
A total of fourteen pyrazoline derivatives were synthesized through cyclo-condensation reactions by chalcone derivatives with different types of semicarbazide.
Kok Tong Wong   +5 more
doaj   +1 more source

THE TAUTOMERISM OF PYRAZOLINES (DIHYDROPYRAZOLES) [PDF]

open access: yesJournal of the Chilean Chemical Society, 2015
The exception to the rule that Δ3-pyrazolines are not stable unless both nitrogen atoms are substituted that has been recently published, Tetrahedron Lett. 55, 2208, (2014), has been proved false. By means of GIAO/B3LYP/6-311++G(d,p) calculations, it has been shown that the product is a pyrazole formed by rearrangement.
ALKORTA, I, ELGUERO, J
openaire   +2 more sources

Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives

open access: yesE-Journal of Chemistry, 2011
Indoloquinoxalin was fused with 2,3 diphenyl quinoxaline by a methylene bridge which was then allowed for acetylation. The acetylated product was made to react with different aromatic aldehydes to give chalcones.
CH. Sridevi, K. Balaji, A. Naidu
doaj   +1 more source

1-[5-(3,5-Dimethoxyphenyl)-3-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

open access: yesIUCrData, 2021
In the title compound, C20H22N2O4, two benzene rings bearing methoxy substituents are connected by a central acetylpyrazoline ring: the dihedral angle between the benzene rings is 83.7 (1)°.
Miri Yoo, Dongsoo Koh
doaj   +1 more source

Azide‐to‐Diazo Transformation Facilitated by Michael Addition via Phosphazide Formation

open access: yesAngewandte Chemie, Volume 138, Issue 23, 1 June 2026.
A new type of Michael addition based on azide‐to‐diazo conversion is disclosed. This unusual transformation proceeds via 1,4‐addition accompanied by N─N bond cleavage of phosphazide intermediates under practical conditions. The high versatility of the resulting Michael adducts enables the synthesis of a wide variety of organonitrogen compounds ...
Tomoki Mano   +3 more
wiley   +2 more sources

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