Results 1 to 10 of about 15,473 (263)

The geroprotective potential of chalcones [PDF]

Nature Communications
Aging is the most important risk factor for multiple pathologies including cardiovascular, neoplastic, metabolic and neurodegenerative diseases. Potential geroprotective strategies involve lifestyle-related, nutritional and pharmacological interventions.
Didac Carmona-Gutierrez, Andreas Zimmermann, Guido Kroemer, Frank Madeo   +3 more
doaj   +5 more sources

Synthesis and Chemical Reactivity of Novel Polyhydroxylated Bis-Chalcones

Medical Sciences Forum, 2022
Chalcones, a class of compounds characterized by two aromatic rings linked through a three carbon α,β-unsaturated carbonyl system, aroused widespread interest due to their (bio)synthesis and broad biological activities.
Rui Pereira, Vera L. M. Silva, Artur M. S. Silva, Daniela Ribeiro, Eduarda Fernandes   +4 more
doaj   +2 more sources

Nematicide Chalcones Act Synergistically on Caenorhabditis elegans and Meloidogyne incognita Without Disrupting Soil Microbial Diversity and with Limited Toxicity to Human Cells [PDF]

Molecules
Plant Parasitic Nematodes (PPNs), such as Meloidogyne incognita, cause significant agricultural losses worldwide. Conventional nematicides like methyl bromide are being phased out due to environmental and health concerns, prompting the search for safer ...
Alejandro Calderón-Urrea, Shantanu Shinde, Sosse Kendoyan, Vukasin M. Jovanovic, Seungmi Ryu, Carlos A. Tristan   +5 more
doaj   +2 more sources

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

Frontiers in Pharmacology, 2021
Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies.
Bahare Salehi, Nasreddine El Omari, Abdelaali Balahbib   +2 more
exaly   +3 more sources

Synthesis of Bis-Chalcones and Evaluation of Its Effect on Peroxide-Induced Cell Death and Lipopolysaccharide-Induced Cytokine Production

Molecules, 2023
Plant secondary metabolites are important sources of biologically active compounds with wide pharmacological potentials. Among the different classes, the chalcones form integral pharmacologically active agents. Natural chalcones and bis-chalcones exhibit
Alby Tom, Jisha Jacob, Manoj Mathews, Rajakrishnan Rajagopal, Ahmed Alfarhan, Damia Barcelo, Arunaksharan Narayanankutty   +6 more
doaj   +1 more source

Recent Updates on Synthetic Strategies of Chalcone Scaffold and their Heterocyclic Derivatives [PDF]

Journal of Advanced Biomedical and Pharmaceutical Sciences, 2023
Chalcones, α,β-unsaturated ketone linking two aromatic moieties gained noticeable attention in the medicinal chemistry area. Chalcone-scaffold construction has proceeded via verified chemical synthetic strategies, including condensation, coupling ...
Mohamed Amin, Montaser Shaykoon, Adel Marzouk, Eman Beshr, Gamal Aburahama   +4 more
doaj   +1 more source

Chalcones as Anti-Glioblastoma Stem Cell Agent Alone or as Nanoparticle Formulation Using Carbon Dots as Nanocarrier

Pharmaceutics, 2022
The current prognosis for glioblastoma is dismal. Treatment-resistant glioblastoma stem cells (GSCs) and the failure of most drugs to reach therapeutic levels within the tumor remain formidable obstacles to successful treatment.
Eduardo A. Veliz, Anastasiia Kaplina, Sajini D. Hettiarachchi, Athina L. Yoham, Carolina Matta, Sabrin Safar, Meghana Sankaran, Esther L. Abadi, Emel Kirbas Cilingir, Frederic A. Vallejo, Winston M. Walters, Steven Vanni, Roger M. Leblanc, Regina M. Graham   +13 more
doaj   +1 more source

Antiviral properties of chalcones and their synthetic derivatives: a mini review [PDF]

Pharmacia, 2020
Chalcones (natural or synthetic derivatives) are aromatic ketones possessing a central backbone that form a core for variety important compounds with different substitutions.
Radoslav Marinov, Nadezhda Markova, Stefka Krumova, Kamelia Yotovska, Maya M. Zaharieva, Petia Genova-Kalou   +5 more
doaj   +3 more sources

Progress of isolation, chemical synthesis and biological activities of natural chalcones bearing 2-hydroxy-3-methyl-3-butenyl group

Frontiers in Chemistry, 2022
Chalcones have a three-carbon α,β-unsaturated carbonyl system composed of two phenolic rings. Many chalcones have shown broad spectrum of biological activities with clinical potentials against various diseases.
Jiadai Zhai, Jiadai Zhai, Bingxia Sun, Feng Sang   +3 more
doaj   +1 more source

Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry

Pharmaceuticals, 2022
Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior ...
Gayathri Rajendran, Deepu Bhanu, Baladhandapani Aruchamy, Prasanna Ramani, Nanjan Pandurangan, Kondapa Naidu Bobba, Eun Jung Oh, Ho Yun Chung, Prakash Gangadaran, Byeong-Cheol Ahn   +9 more
doaj   +1 more source