Results 11 to 20 of about 10,638 (220)

Synthesis of Bis-Chalcones and Evaluation of Its Effect on Peroxide-Induced Cell Death and Lipopolysaccharide-Induced Cytokine Production

Molecules, 2023
Plant secondary metabolites are important sources of biologically active compounds with wide pharmacological potentials. Among the different classes, the chalcones form integral pharmacologically active agents. Natural chalcones and bis-chalcones exhibit
Alby Tom, Jisha Jacob, Manoj Mathews, Rajakrishnan Rajagopal, Ahmed Alfarhan, Damia Barcelo, Arunaksharan Narayanankutty   +6 more
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Recent Updates on Synthetic Strategies of Chalcone Scaffold and their Heterocyclic Derivatives [PDF]

Journal of Advanced Biomedical and Pharmaceutical Sciences, 2023
Chalcones, α,β-unsaturated ketone linking two aromatic moieties gained noticeable attention in the medicinal chemistry area. Chalcone-scaffold construction has proceeded via verified chemical synthetic strategies, including condensation, coupling ...
Mohamed Amin, Montaser Shaykoon, Adel Marzouk, Eman Beshr, Gamal Aburahama   +4 more
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Chalcones as Anti-Glioblastoma Stem Cell Agent Alone or as Nanoparticle Formulation Using Carbon Dots as Nanocarrier

Pharmaceutics, 2022
The current prognosis for glioblastoma is dismal. Treatment-resistant glioblastoma stem cells (GSCs) and the failure of most drugs to reach therapeutic levels within the tumor remain formidable obstacles to successful treatment.
Eduardo A. Veliz, Anastasiia Kaplina, Sajini D. Hettiarachchi, Athina L. Yoham, Carolina Matta, Sabrin Safar, Meghana Sankaran, Esther L. Abadi, Emel Kirbas Cilingir, Frederic A. Vallejo, Winston M. Walters, Steven Vanni, Roger M. Leblanc, Regina M. Graham   +13 more
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Synthesis and Chemical Reactivity of Novel Polyhydroxylated Bis-Chalcones

Medical Sciences Forum, 2022
Chalcones, a class of compounds characterized by two aromatic rings linked through a three carbon α,β-unsaturated carbonyl system, aroused widespread interest due to their (bio)synthesis and broad biological activities.
Rui Pereira, Vera L. M. Silva, Artur M. S. Silva, Daniela Ribeiro, Eduarda Fernandes   +4 more
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Antiviral properties of chalcones and their synthetic derivatives: a mini review [PDF]

Pharmacia, 2020
Chalcones (natural or synthetic derivatives) are aromatic ketones possessing a central backbone that form a core for variety important compounds with different substitutions.
Radoslav Marinov, Nadezhda Markova, Stefka Krumova, Kamelia Yotovska, Maya M. Zaharieva, Petia Genova-Kalou   +5 more
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Progress of isolation, chemical synthesis and biological activities of natural chalcones bearing 2-hydroxy-3-methyl-3-butenyl group

Frontiers in Chemistry, 2022
Chalcones have a three-carbon α,β-unsaturated carbonyl system composed of two phenolic rings. Many chalcones have shown broad spectrum of biological activities with clinical potentials against various diseases.
Jiadai Zhai, Jiadai Zhai, Bingxia Sun, Feng Sang   +3 more
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Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry

Pharmaceuticals, 2022
Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior ...
Gayathri Rajendran, Deepu Bhanu, Baladhandapani Aruchamy, Prasanna Ramani, Nanjan Pandurangan, Kondapa Naidu Bobba, Eun Jung Oh, Ho Yun Chung, Prakash Gangadaran, Byeong-Cheol Ahn   +9 more
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Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

Molecules, 2021
Chalcones are secondary metabolites belonging to the flavonoid (C6-C3-C6 system) family that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant flavonoids.
Mithun Rudrapal, Johra Khan, Abdul Aziz Bin Dukhyil, Randa Mohammed Ibrahim Ismail Alarousy, Emmanuel Ifeanyi Attah, Tripti Sharma, Shubham Jagdish Khairnar, Atul Rupchand Bendale   +7 more
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Structural, Vibrational and Electrochemical Analysis and Antibacterial Potential of Isomeric Chalcones Derived from Natural Acetophenone

Applied Sciences, 2020
Background: Chalcones are part of a family of small phenolic compounds that are being extensively studied for presenting a diversity of molecular structures and biological activities. In this paper, two chalcones, (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-
Priscila Teixeira da Silva, Thiago Sampaio de Freitas, Diniz Maciel Sena, Paulo Nogueira Bandeira, Murilo Ségio da Silva Julião, Emmanuel Silva Marinho, Ana Aline Coêlho Alcanfor, Emanuelle Machado Marinho, Pedro de Lima-Neto, Carlos Emídio Sampaio Nogueira, Henrique Douglas Melo Coutinho, Antonio Linkoln Alves Borges Leal, Humberto Medeiros Barreto, Natália Martins, Alexandre Magno Rodrigues Teixeira, Hélcio Silva dos Santos   +15 more
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Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles

Pharmaceutics, 2023
Colon cancer poses a complex and substantial global health challenge, necessitating innovative therapeutic approaches. Chalcones, a versatile class of compounds with diverse pharmacological properties, have emerged as promising candidates for addressing ...
Soufyane Hba, Suzan Ghaddar, Hicham Wahnou, Aline Pinon, Riad El Kebbaj, Christelle Pouget, Vincent Sol, Bertrand Liagre, Mounia Oudghiri, Youness Limami   +9 more
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