Results 31 to 40 of about 10,638 (220)

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

Frontiers in Pharmacology, 2021
Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies.
Bahare Salehi, Cristina Quispe, Imane Chamkhi, Imane Chamkhi, Nasreddine El Omari, Abdelaali Balahbib, Javad Sharifi-Rad, Javad Sharifi-Rad, Abdelhakim Bouyahya, Muhammad Akram, Mehwish Iqbal, Anca Oana Docea, Constantin Caruntu, Constantin Caruntu, Gerardo Leyva-Gómez, Abhijit Dey, Miquel Martorell, Miquel Martorell, Daniela Calina, Víctor López, Víctor López, Francisco Les, Francisco Les   +22 more
doaj   +1 more source

Green Synthesis, Characterization, Photophysical and Electrochemical Properties of Bis-chalcones

International Journal of Electrochemical Science, 2014
Donor-acceptor conjugated dienes (bis-chalcones) were synthesized via an ultrasonic radiation, accomplished by the reaction between 3-acetyl-2,5-dimethylthiophene/1 (2,5-dimethyl-furan-3-yl)- ethanone and terephthalaldehyde.
Abdullah M. Asiri, Hadi M. Marwani, Khalid A. Alamry, Muhammed S. Al-Amoudi, Salman A. Khan, Samy A. El-Daly   +5 more
doaj   +1 more source

A Comprehensive Review of Aminochalcones

Molecules, 2020
Chalcones, members of the flavonoid family, display a plethora of interesting biological activities including but not limited to antioxidant, anticancer, antimicrobial, anti-inflammatory, and antiprotozoal activities.
Rimsha Irfan, Shikufa Mousavi, Meshari Alazmi, Rahman Shah Zaib Saleem   +3 more
doaj   +1 more source

Adaptive Hydrogenation of Alkynes Using CO as a Molecular Trigger to Selectively Produce Alkanes or Z‐Alkenes

Angewandte Chemie, EarlyView.
One catalyst for two products: CO acts as a molecular trigger for adaptive alkyne hydrogenation using supported Pd nanoparticles. The catalyst reversibly switches between the formation of alkanes under H2 and Z‐alkenes under H2/CO for 37 structurally diverse alkynes.
Manisha Durai, Lachlan Sharp‐Bucknall, Tim Alexander Schubert, Jacob Johny, John‐Tommes Krzeslack, Walid Hetaba, Walter Leitner, Alexis Bordet   +7 more
wiley   +2 more sources

Pharmacological potential of natural chalcones: a recent studies and future perspective

Frontiers in Pharmacology
Chalcones isolated from natural sources are the primary metabolites of numerous biologically intriguing and pharmacologically essential drugs. Chalcones’ pharmacological properties are believed to result from a double bond conjugated to carbonyl ...
Suman Adhikari, Priyatosh Nath, Vishal Kumar Deb, Niranjan Das, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy   +6 more
doaj   +1 more source

Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives

E-Journal of Chemistry, 2011
Indoloquinoxalin was fused with 2,3 diphenyl quinoxaline by a methylene bridge which was then allowed for acetylation. The acetylated product was made to react with different aromatic aldehydes to give chalcones.
CH. Sridevi, K. Balaji, A. Naidu
doaj   +1 more source

Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum. In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast cancer cells (MCF-7 line) and triple-negative breast cancer (TNBC ...
Mariana Bastos dos Santos, Daiane Bertholin Anselmo, Jéssica Gisleine de Oliveira, Bruna V. Jardim-Perassi, Diego Alves Monteiro, Gabriel Silva, Eleni Gomes, Ana Lucia Fachin, Mozart Marins, Débora Aparecida Pires de Campos Zuccari, Luis Octavio Regasini   +10 more
doaj   +1 more source

Mechanochemical synthesis of indolyl chalcones with antiproliferative activity

Green Chemistry Letters and Reviews, 2022
An efficient eco-friendly one-step mechanochemical synthesis of indole hybrid chalcones via the Claisen–Schmidt condensation of 1-methylindole-3-carboxaldehyde with various substituted acetophenones is described using liquid assisted grinding in a high ...
Zuzana Kudličková, Martin Stahorský, Radka Michalková, Mária Vilková, Matej Baláž   +4 more
doaj   +1 more source

A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones

Advanced Science, EarlyView.
Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim, Muhammad Israr, You Kyoung Chung, Shinwon Ham, Joonsuk Huh, Han Yong Bae   +5 more
wiley   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source