A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter. [PDF]
, 2017 The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by ...
Ao, Ming-Tao +9 more
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Green Synthesis, Characterization, Photophysical and Electrochemical Properties of Bis-chalcones
International Journal of Electrochemical Science, 2014 Donor-acceptor conjugated dienes (bis-chalcones) were synthesized via an ultrasonic radiation, accomplished by the reaction between 3-acetyl-2,5-dimethylthiophene/1 (2,5-dimethyl-furan-3-yl)- ethanone and terephthalaldehyde.
Abdullah M. Asiri +5 more
doaj +1 more source
A Comprehensive Review of Aminochalcones
Molecules, 2020 Chalcones, members of the flavonoid family, display a plethora of interesting biological activities including but not limited to antioxidant, anticancer, antimicrobial, anti-inflammatory, and antiprotozoal activities.
Rimsha Irfan +3 more
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Molecular docking and dynamics analysis of halogenated imidazole chalcone as anticancer compounds [PDF]
Pharmacia, 2023 Cancer is one of the three biggest causes of death in the world. The development of new drugs against this disease is a serious study that must be carried out in order to reduce mortality and extend the life span of sufferers.
Winarto Haryadi, Harno Dwi Pranowo
doaj +3 more sources
Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives
E-Journal of Chemistry, 2011 Indoloquinoxalin was fused with 2,3 diphenyl quinoxaline by a methylene bridge which was then allowed for acetylation. The acetylated product was made to react with different aromatic aldehydes to give chalcones.
CH. Sridevi, K. Balaji, A. Naidu
doaj +1 more source
Mechanochemical synthesis of indolyl chalcones with antiproliferative activity
Green Chemistry Letters and Reviews, 2022 An efficient eco-friendly one-step mechanochemical synthesis of indole hybrid chalcones via the Claisen–Schmidt condensation of 1-methylindole-3-carboxaldehyde with various substituted acetophenones is described using liquid assisted grinding in a high ...
Zuzana Kudličková +4 more
doaj +1 more source
Chalcone-based Selective Inhibitors of a C4 Plant Key Enzyme as Novel Potential Herbicides [PDF]
, 2016 Weeds are a challenge for global food production due to their rapidly evolving resistance against herbicides. We have identified chalcones as selective inhibitors of phosphoenolpyruvate carboxylase (PEPC), a key enzyme for carbon fixation and biomass ...
Bott, M. +7 more
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Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs [PDF]
, 2009 Garcinol, harvested from Garcinia indica, has traditionally been used in tropical regions and appreciated for centuries; however its biological properties are only beginning to be elucidated.
Subhash Padhye +3 more
core +3 more sources
Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum. In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast cancer cells (MCF-7 line) and triple-negative breast cancer (TNBC ...
Mariana Bastos dos Santos +10 more
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Exploring the Phytochemical Landscape of the Early-Diverging Flowering Plant Amborella trichopoda Baill. [PDF]
, 2019 Although the evolutionary significance of the early-diverging flowering plant Amborella (Amborella trichopoda Baill.) is widely recognized, its metabolic landscape, particularly specialized metabolites, is currently underexplored.
Chang, Lijing +3 more
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