Results 1 to 10 of about 30,495 (265)

Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent

Molecules, 2021
Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region.
Respati Tri Swasono, Jumina Jumina
exaly   +4 more sources

Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model [PDF]

Molecules, 2013
The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to ...
Yau-Hung Chen, Yun-Hsin Wang, Chi-Chung Wen   +2 more
exaly   +2 more sources

Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model [PDF]

Molecules, 2014
The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and ...
Hui-Min Chen, Yun-Hsin Wang, Ching-Yuh Chern   +2 more
exaly   +2 more sources

Pharmacotherapeutics Applications and Chemistry of Chalcone Derivatives [PDF]

, 2022
Chalcones have been well examined in the extant literature and demonstrated antibacterial, antifungal, anti-inflammatory, and anticancer properties.
Nurolaini Kifli, -, Andi Hermansyah, Mei Jun Loy, Hossain, Md. Sanower, Ming, Long Chiau, Mei Jun Loy, -, Jagjit Singh Dhaliwa, -, Dhaliwal, Sachinjeet Kaur Sodhi, Khang Wen Goh, -, Yassin, Hayati, Hayati Yassin, Md. Sanower Hossain, Hossain, Md Sanower, Said Moshawih, -, Dhaliwal, Jagjit Singh, Sachinjeet Kaur Sodhi Dhaliwal, -, Pg Hj Md Yassin, Hayati, Hui Poh Goh, Kotra, Vijay, Vijay, Kotra, Vijay Kotra, -, Nurolaini Kifli, Goh, Khang Wen, Moshawih, Said, Said Moshawih, Long Chiau Ming, -, Vijay Kotra, Khang Wen Goh, Long Chiau Ming, Sachinjeet Kaur Sodhi Dhaliwal, Hermansyah, Andi, Sodhi Dhaliwal, Sachinjeet Kaur, Sanower Hossain, -, Loy, Mei Jun, Hayati Yassin, -, Goh, Hui Poh, Andi Hermansyah, -, Jagjit Singh Dhaliwal, Kifli, Nurolaini, Hui Poh Goh, -   +39 more
core   +1 more source

Novel chalcone-based fluorescent human histamine H 3 receptor ligands as pharmacological tools [PDF]

, 2012
Novel fluorescent chalcone-based ligands at human histamine H(3) receptors (hH(3)R) have been designed, synthesized, and characterized. Compounds described are non-imidazole analogs of ciproxifan with a tetralone motif.
Miriam Tomasch, Lilia Weizel, Weizel, Lilia, Stark, Holger, Tomasch, Miriam, Holger Stark, Schwed, J. Stephan, J. Stephan Schwed   +7 more
core   +1 more source

Green light LED activated ligation of a scalable, versatile chalcone chromophore

, 2021
Herein we introduce a photoreactive chalcone moiety that can be synthesized at a scale of several grams with ease, and efficiently undergoes a [2 + 2] photocycloaddition with light up to just below 500 nm as determined by an action plot.
De Bruycker, Kevin, Micallef, Aaron S, Frisch, Hendrik, Irshadeen, Ishrath Mohamed, Barner-Kowollik, Christopher, Walden, Sarah L   +5 more
core   +1 more source

Chalcone-Based Pyridinium Salts and Their Diastereoselective Dearomatization To Access Bibridged Benzoazepines

, 2020
New chalcone-based pyridinium salts have been successfully exploited, which could smoothly participate in the highly diastereoselective dearomatization with binucleophilic enaminones by taking advantage of their multiple reactive sites to construct ...
Zhao-Hui Cui (6872906), Zhan-Wei Bu (4016654), Jun-Wei Zhao (1711252), Le-Le Wang (8270223), Hua-Bin Han (8270226), Qi-Lin Wang (2194720)   +5 more
core   +1 more source

Presentation_1_A Novel Multifunctional 5,6-Dimethoxy-Indanone-Chalcone-Carbamate Hybrids Alleviates Cognitive Decline in Alzheimer’s Disease by Dual Inhibition of Acetylcholinesterase and Inflammation.pdf

, 2022
BackgroundsAlzheimer’s disease (AD) is a multifactorial neurodegenerative disease. The treatment of AD through multiple pathological targets may generate therapeutic efficacy better.
Yu Qiu (143428), Qin Wu (139038), Zhipei Sang (4427695), Chan Liu (5545364), Jingshan Shi (711936), Hong Pan (8686)   +5 more
core   +1 more source

Chalcone-based imidazo[2,1-b]thiazole derivatives: synthesis, crystal structure, potent anticancer activity, and computational studies

, 2023
In this work, two novel chalcone-based imidazothiazole derivatives ITC-1 and ITC-2 were synthesized and characterized by 1H NMR, 13C NMR and high-resolution mass spectrometry with electrospray ionization, and chemical structure of ITC-1 was confirmed by ...
Burçin Türkmenoğlu (17456071), Mohammed Koudad (17456074), El Hassane Anouar (7245125), Abdelouahad Oussaid (17456077), Khalid Karrouchi (6007748), Noureddine Benchat (14349902), Ahmet Altay (12158717), Necmi Dege (3877936), Said Dadou (17456065), Cemile Baydere (17456068)   +9 more
core   +1 more source

Chalcone-Thiazole Hybrids: Rational Design, Synthesis, and Lead Identification against 5‑Lipoxygenase

, 2019
A hybrid pharmacophore approach is used to design and synthesize novel chalcone-thiazole hybrid molecules. Herein, thiazole has been hybridized with chalcone to obtain a new class of 5-LOX inhibitors.
Mukesh Doble (412086), S. L. Manju (7381205), Shweta Sinha (6613892)   +2 more
core   +1 more source