Results 1 to 10 of about 23,013 (219)

Chalcone and Trans-Chalcone Induce Transcriptomic Changes in Caenorhabditis elegans Compatible with a Novel Cumulative Damage Mode of Action [PDF]

Molecules
Chalcones, a subclass of flavonoid-derived phenolic compounds, have demonstrated promising anthelmintic activity against parasitic nematodes. This study aimed to obtain insights into the biological effects a cis/trans mixture of chalcone and its ...
Giulio Galli, Carl S. Bruun, Carlos García-Estrada, Rafael Balaña-Fouce, María Martinez-Valladares, Tina V. A. Hansen   +5 more
doaj   +2 more sources

Phenothiazine dye-loaded chitosan cryogels as multifunctional antibacterial wound dressings [PDF]

Scientific Reports
Cryogels, owing to their low density, high porosity, lightweight structure, and interconnected three-dimensional network, have gained significant attention for biomedical applications.
Reem Ghonaim, Bahaa A. Hemdan, Hesham R. El-Seedi, Mohamed M. A. Badr, Tarek S. Aysha, Mervat S. El-Sedik, Samar A. El-Kholy, Mehrez E. El-Naggar   +7 more
doaj   +2 more sources

Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent

Molecules, 2021
Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region.
Jumina Jumina, Respati Tri Swasono
exaly   +3 more sources

trans-Chalcone protects male rats against high-fat emulsion-induced pancreatic injury by inhibiting TNF-α and MCP-1 expression [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023
Background. High-fat diet (HFD) intake is linked to ectopic fat deposition in the pancreas. It also causes pancreatic inflammatory lesions. trans-Chalcone is a simple chalcone with protective effects against HFD-induced metabolic disorders.
Elham Karimi-Sales, Mohammad Reza Alipour   +1 more
doaj   +1 more source

Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood.
Elham Karimi Sales, Sajad Jeddi, Abbas Ebrahimi-Kalan, Mohammad Reza Alipour   +3 more
doaj   +1 more source

The solubility and stability of heterocyclic chalcones compared with trans-chalcone [PDF]

Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2020
Heterocyclic chalcones are a recently explored subgroup of chalcones that have sparked interest due to their significant antibacterial and antifungal capabilities. Herein, the structure and solubility of two such compounds, (E)-1-(1H-pyrrol-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one and (E)-3-phenyl-1-(1H-pyrrol-2-yl)prop-2-en-1-one, are assessed.
Stephen G. Sweeting, Charlie L. Hall, Jason Potticary, Natalie E. Pridmore, Stephen D. Warren, Matthew E. Cremeens, Gemma D. D'Ambruoso, Masaomi Matsumoto, Simon R. Hall   +8 more
openaire   +4 more sources

Analysis of Chalcone Synthase and Chalcone Isomerase Gene Expression in Pigment Production Pathway at Different Flower Colors of Petunia Hybrida [PDF]

Journal of Cell and Molecular Research, 2016
Variegation in flower color is commonly observed in many plant species and also occurs on petunia (Petunia hybrida) as an ornamental plant. Variegated plants are highly valuable in the floricultural market.
fatemeh keykha, Abdol Reza Bagheri, Nasrin Moshtaghi   +2 more
doaj   +1 more source

Protective Role of trans-Chalcone against the Progression from Simple Steatosis to Non-alcoholic Steatohepatitis: Regulation of miR-122, 21, 34a, and 451 [PDF]

Advanced Pharmaceutical Bulletin, 2022
Purpose: Non-alcoholic steatohepatitis (NASH) is an inflammatory disorder and an aggressive form of fatty liver disease. Certain microRNAs, including miR-122, 21, 34a, and 451, are involved in the transition from steatosis to NASH.
Elham Karimi-Sales, Sajad Jeddi, Abbas Ebrahimi-Kalan, Mohammad Reza Alipour   +3 more
doaj   +1 more source

A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells

Journal of International Medical Research, 2020
Objective To investigate the in vitro and in vivo anticancer effects of a chalcone against KYSE-4 esophageal cancer cells. Methods A chalcone was synthesized via the molecular hybridization strategy based on the anticancer activity of chalcone and ...
Jie Chen, Chun-Yan Kang, Zhao-Xia Niu, Hui-Cong Zhou, Hong-Mei Yang   +4 more
doaj   +1 more source

Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition.

PLoS ONE, 2018
Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-
Gabriel Silva, Mozart Marins, Nadda Chaichanasak, Yongdae Yoon, Ana Lúcia Fachin, Vitor Caressato Pinhanelli, Luis Octávio Regasini, Mariana Bastos Dos Santos, Gabriela Miranda Ayusso, Beatriz de Carvalho Marques, Wells W Wu, Je-Nie Phue, Rong-Fong Shen, Seung Joon Baek   +13 more
doaj   +1 more source