Results 31 to 40 of about 23,013 (219)

Comparative Molecular Mechanisms of Biosynthesis of Naringenin and Related Chalcones in Actinobacteria and Plants: Relevance for the Obtention of Potent Bioactive Metabolites

Antibiotics, 2022
Naringenin and its glycosylated derivative naringin are flavonoids that are synthesized by the phenylpropanoid pathway in plants. We found that naringenin is also formed by the actinobacterium Streptomyces clavuligerus, a well-known microorganism used to
Juan F. Martín, Paloma Liras
doaj   +1 more source

Thermal study of chalcones [PDF]

Journal of Thermal Analysis and Calorimetry, 2018
Chalcones α-β-unsaturated ketones are found in large plant species. Synthesis of chalcones and its three analogues hydroxy group at 2′, 3′ and 4′ positions (2–4) was carried out. The studies of thermal behavior were made by thermogravimetry (TG) and differential scanning calorimetry, both under oxygen and nitrogen purge gases.
Marcelo Kobelnik, Leonardo Miziara Barboza Ferreira, Luis Octavio Regasini, Luiz Antonio Dutra, Vanderlan da Silva Bolzani, Clóvis Augusto Ribeiro   +5 more
openaire   +2 more sources

Study of Michael addition on chalcones and or chalcone analogues

Journal of Saudi Chemical Society, 2012
AbstractMichael addition reaction of 1,3-diphenyl-propenone 1a, e, and f with o-amino thiophenol in the presence of indium trichloride gave the benzothiazine derivatives 2a–c. Condensation of the compound 1a, e with o-phenylene diamine in triethylamine gave the benzodiazepine derivatives 3a–b.
Al-Jaber, Nabila A., Bougasim, Amal S.A., Karah, Makarem M.S.   +2 more
openaire   +1 more source

STUDI PELEPASAN TERKONTROL TERHADAP NANOENKAPSULASI DIMETOKSI AMINO CALKON SEBAGAI DESAIN KANDIDAT SENYAWA ANTI KANKER YANG EFEKTIF

Jurnal Kimia Riset, 2016
ABSTRAK Enkapsulasi merupakan sebuah proses dimana partikel kecil dikemas dalam sebuah partikel yang lebih besar sehingga membentuk kapsul. Metode tersebut akan digunakan untuk memodifikasi calkon, senyawa anti kanker yang memiliki kelarutan dalam air ...
Mochamamad Zakki Fahmi, Hery Suwito, Shofi Yasmin Nurain, Yogi Putra Hidayatullah   +3 more
doaj   +1 more source

chalcones [PDF]

, 2014
Citation: 'chalcones' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.C00966 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones

Advanced Science, EarlyView.
Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim, Muhammad Israr, You Kyoung Chung, Shinwon Ham, Joonsuk Huh, Han Yong Bae   +5 more
wiley   +1 more source

In silico screening of chalcones against Epstein-Barr virus nuclear antigen 1 protein [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2020
The Epstein-Barr nuclear antigen 1 (EBNA1) is a crucial protein expressed by the Epstein-Barr virus (EBV). The EBNA1 is necessary for the replication and transcriptional regulation of latent gene expression of the EBV.
Nitchakan Darai, Panupong Mahalapbutr, Kanyani Sangpheak, Chompoonut Rungnim, Peter Wolschann, Nawee Kungwan, Thanyada Rungrotmongkol   +6 more
doaj   +1 more source

Phthalocyanine-chalcone conjugates

Journal of Porphyrins and Phthalocyanines, 2016
A phthalocyanine-chalcone conjugate was previously reported to retain the full photodynamic activity of the phthalocyanine and a slightly lowered antivascular effect of the chalcone. Assuming that it was due to an insufficient release of the chalcone, we described here several grafting modes applied to the preparation of phthalocyanine-chalcone ...
Aribi, Fallia, Vey, Charlene, Topkaya, Derya, Kostakoglu, Sinem Tuncel, Fournier-Dit-Chabert, Jérémie, Büyükekşi, Sebile Işik, Taşkin, Gökçe Canan, Alpugan, Serkan, Albrieux, Florian, Gürek, Ayşe Gül, Cucca, Mélissa, Bennis, Khalil, Atilla, Devrim, Ahsen, Vefa, Ducki, Sylvie, Dumoulin, Fabienne   +15 more
openaire   +3 more sources

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Trans-chalcone activity against Trichophyton rubrum relies on an interplay between signaling pathways related to cell wall integrity and fatty acid metabolism

BMC Genomics, 2019
Background Trichophyton rubrum is the main etiological agent of skin and nail infections worldwide. Because of its keratinolytic activity and anthropophilic nature, infection models based on the addition of protein substrates have been employed to assess
Tamires Aparecida Bitencourt, Claudia Macedo, Matheus Eloy Franco, Marina Campos Rocha, Igor Sawasaki Moreli, Bruna Aline Micheloto Cantelli, Pablo Rodrigo Sanches, Rene Oliveira Beleboni, Iran Malavazi, Geraldo Aleixo Passos, Mozart Marins, Ana Lúcia Fachin   +11 more
doaj   +1 more source