Results 31 to 40 of about 33,682 (280)
Bangladesh Journal of Pharmacology, 2016 The aim of the current study was to investigate the in vitro and in vivo anti-tumor effects of naringenin chalcone in U87MG human glioblastoma cells and in xenograft mice model.
Shuai Zhang +4 more
doaj +1 more source
, 2022 BackgroundsAlzheimer’s disease (AD) is a multifactorial neurodegenerative disease. The treatment of AD through multiple pathological targets may generate therapeutic efficacy better.
Yu Qiu (143428) +5 more
core +1 more source
Angewandte Chemie, EarlyView.Cancer stem cells (CSCs) drive metastasis, relapse and resist conventional apoptosis‐inducing chemotherapies. We report a cobalt(III)‐cyclam complex with pyrene and diflunisal moieties that reduces the viability of breast CSCs at low micromolar concentrations.
Jiaxin Fang +7 more
wiley +2 more sources
Synthesis and Biological Evaluation of Amino Chalcone Derivatives as Antiproliferative Agents
Molecules, 2020 Chalcone is a common scaffold found in many biologically active compounds. The chalcone scaffold was also frequently utilized to design novel anticancer agents with potent biological efficacy.
Chao-Fan Lu +14 more
doaj +1 more source
Chalcone Scaffold: A masterpiece for medicinal chemistry recent biological insights [PDF]
Journal of Advanced Biomedical and Pharmaceutical Sciences, 2023 In medicinal chemistry, privileged structures are frequently used as an effective template for finding new drugs. Chalcone is a typical simple sugar that occurs in a wide variety of naturally occurring compounds. Chalcone derivatives are also prepared in
Mohamed Abdelaziz +3 more
doaj +1 more source
Angewandte Chemie, EarlyView.One catalyst for two products: CO acts as a molecular trigger for adaptive alkyne hydrogenation using supported Pd nanoparticles. The catalyst reversibly switches between the formation of alkanes under H2 and Z‐alkenes under H2/CO for 37 structurally diverse alkynes.
Manisha Durai +7 more
wiley +2 more sources
Acta Pharmaceutica Sinica B, 2018 Prenylflavonoids are valuable natural products that have diverse biological properties, and are usually generated biologically by multiple metabolic enzymes in nature.
Jianhua Li +6 more
doaj +1 more source
Anticancer and antimicrobial activity of methoxy amino chalcone derivatives [PDF]
, 2015 A series of methoxy amino chalcone derivatives have been synthesized and evaluated for their anticancer activity against breast cancer cells line T47D and their antimicrobial activity against Escherichia coli ATCC 25923, Staphylococcus aureus ATCC 25922,
Mustofa, .- +4 more
core +2 more sources
Regulation of autophagy-related gene expressions by Trans-chalcone in the lungs of adult male rats [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریزBackground. Autophagy is responsible for maintaining cellular homeostasis by degrading and recycling macromolecules and unwanted intracellular components, such as damaged organelles.
Fatemeh Salehi Mazdeh +4 more
doaj +1 more source
Chalcone suppresses tumor growth through NOX4-IRE1α sulfonation-RIDD-miR-23b axis
Redox Biology, 2021 Chalcone is a polyphenolic compound found abundantly in natural plant components. They have been acclaimed as potential antitumor compounds in multiple tumor cells. However, not much attention has been paid to elucidate its antitumor mechanism of action.
Hyun-Kyoung Kim +8 more
doaj +1 more source