Results 51 to 60 of about 33,682 (280)

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Therapeutic potential of curcumin and dimethyl chalcone in chronic constriction injury-induced neuropathic pain: Behavioural and histological insights

Pharmacological Research - Modern Chinese Medicine
Introduction: TRPA1, a key molecule in the pathogenesis of neuropathic pain, oxidative stress, and neurogenic inflammation, few mechanism-based drug therapies are available, and the current study explores the anti-neuropathic activities of curcumin and ...
Swathi V, Shabna Roupal Morais, Sailendra Kumar Mahanta, Sisir Nandi, Chandru R, Latha S   +5 more
doaj   +1 more source

In silico screening of chalcones against Epstein-Barr virus nuclear antigen 1 protein [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2020
The Epstein-Barr nuclear antigen 1 (EBNA1) is a crucial protein expressed by the Epstein-Barr virus (EBV). The EBNA1 is necessary for the replication and transcriptional regulation of latent gene expression of the EBV.
Nitchakan Darai, Panupong Mahalapbutr, Kanyani Sangpheak, Chompoonut Rungnim, Peter Wolschann, Nawee Kungwan, Thanyada Rungrotmongkol   +6 more
doaj   +1 more source

Thermal study of chalcones [PDF]

Journal of Thermal Analysis and Calorimetry, 2018
Chalcones α-β-unsaturated ketones are found in large plant species. Synthesis of chalcones and its three analogues hydroxy group at 2′, 3′ and 4′ positions (2–4) was carried out. The studies of thermal behavior were made by thermogravimetry (TG) and differential scanning calorimetry, both under oxygen and nitrogen purge gases.
Marcelo Kobelnik, Leonardo Miziara Barboza Ferreira, Luis Octavio Regasini, Luiz Antonio Dutra, Vanderlan da Silva Bolzani, Clóvis Augusto Ribeiro   +5 more
openaire   +2 more sources

Developmentally and transgene regulated nuclear processing of primary transcripts of chalcone synthase A in petunia

, 2000
The introduction of chalcone synthase A transgenes into petunia plants can result in degradation of chalcone synthase A RNAs and loss of chalcone synthase, a process called cosuppression or post-transcriptional gene silencing.
Metzlaff, M., O'Dell, M., Flavell, R.B., Hellens, R.P.   +3 more
core   +1 more source

Unveiling the Anticancer Properties of New Synthesized Alkoxy‐ and Methyl Thio‐Chalcone Derivatives

Natural Sciences
Breast and cervical cancers are a serious problem and the leading cause of death in women in this decade. Chalcone is a promising compound with great potential for anticancer use.
Nurcahyo Iman Prakoso, Taiki Umezawa, Dwiarso Rubiyanto, Azizah Zelia Kusumo, Fanny Septianingtyas, Muhamad Ikhsan Nurochman, Laras Kristianti, Salmahaminati, Pinus Jumaryatno, Minori Abe   +9 more
doaj   +1 more source

Trans-chalcone activity against Trichophyton rubrum relies on an interplay between signaling pathways related to cell wall integrity and fatty acid metabolism

BMC Genomics, 2019
Background Trichophyton rubrum is the main etiological agent of skin and nail infections worldwide. Because of its keratinolytic activity and anthropophilic nature, infection models based on the addition of protein substrates have been employed to assess
Tamires Aparecida Bitencourt, Claudia Macedo, Matheus Eloy Franco, Marina Campos Rocha, Igor Sawasaki Moreli, Bruna Aline Micheloto Cantelli, Pablo Rodrigo Sanches, Rene Oliveira Beleboni, Iran Malavazi, Geraldo Aleixo Passos, Mozart Marins, Ana Lúcia Fachin   +11 more
doaj   +1 more source

INVESTIGATION OF ANTICANCER MECHANISMS OF A CHALCONE/XANTHINE HYBRID IN NON-SMALL CELL LUNG CANCER [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Despite major advances in therapy, Lung cancer remains the major cause of death among cancer cases. Chalcone/xanthine Hybrid is a synthetic xanthine derivative that was found to exert an anticancer action in various cancer types.
Omar Elrehany, Al - Shaimaa Ahmed, Hesham Abou-Zied, Alaa Hayallah, Mohamed Abdel-Aziz, Maiiada Nazmy   +5 more
doaj   +1 more source

Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones

Pharmacology & Pharmacy, 2011
A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. A novel series of pyrazolicchalcones (5a-c) have been synthesized by the reaction of respective chalcones (4a-c) and hydrazine hydrate.
Tan Nhut Doan, Dao Thanh Tran
openaire   +2 more sources