Results 51 to 60 of about 30,495 (265)

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones

Pharmacology & Pharmacy, 2011
A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. A novel series of pyrazolicchalcones (5a-c) have been synthesized by the reaction of respective chalcones (4a-c) and hydrazine hydrate.
Tan Nhut Doan, Dao Thanh Tran
openaire   +2 more sources

INVESTIGATION OF ANTICANCER MECHANISMS OF A CHALCONE/XANTHINE HYBRID IN NON-SMALL CELL LUNG CANCER [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Despite major advances in therapy, Lung cancer remains the major cause of death among cancer cases. Chalcone/xanthine Hybrid is a synthetic xanthine derivative that was found to exert an anticancer action in various cancer types.
Omar Elrehany, Al - Shaimaa Ahmed, Hesham Abou-Zied, Alaa Hayallah, Mohamed Abdel-Aziz, Maiiada Nazmy   +5 more
doaj   +1 more source

A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones

Advanced Science, EarlyView.
Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim, Muhammad Israr, You Kyoung Chung, Shinwon Ham, Joonsuk Huh, Han Yong Bae   +5 more
wiley   +1 more source

Developmentally and transgene regulated nuclear processing of primary transcripts of chalcone synthase A in petunia

, 2000
The introduction of chalcone synthase A transgenes into petunia plants can result in degradation of chalcone synthase A RNAs and loss of chalcone synthase, a process called cosuppression or post-transcriptional gene silencing.
Metzlaff, M., O'Dell, M., Flavell, R.B., Hellens, R.P.   +3 more
core   +1 more source

Simple chalcones and bis-chalcones ethers as possible pleiotropic agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015
The synthesis, the antioxidative properties and the lipoxygenase (LOX) and acetylcholinesterase (AChE) inhibition of a number of 4-hydroxy-chalcones diversely substituted as well as of a series of bis-chalcones ether derivatives are reported. The chalcones derivatives were readily produced using a Claisen-Schmidt condensation in a ultra sound bath in ...
Liargkova, T., Hadjipavlou-Litina, D.J., Koukoulitsa, C., Voulgari, E., Avgoustakis, C.   +4 more
openaire   +3 more sources

Unveiling the Anticancer Properties of New Synthesized Alkoxy‐ and Methyl Thio‐Chalcone Derivatives

Natural Sciences
Breast and cervical cancers are a serious problem and the leading cause of death in women in this decade. Chalcone is a promising compound with great potential for anticancer use.
Nurcahyo Iman Prakoso, Taiki Umezawa, Dwiarso Rubiyanto, Azizah Zelia Kusumo, Fanny Septianingtyas, Muhamad Ikhsan Nurochman, Laras Kristianti, Salmahaminati, Pinus Jumaryatno, Minori Abe   +9 more
doaj   +1 more source

Evaluation and Optimization of the Anti-Melanogenic Activity of 1-(2-Cyclohexylmethoxy-6-hydroxy-phenyl)-3-(4-hydroxymethyl-phenyl)-propenone Derivatives

Molecules, 2019
The chemical modification and optimization of biologically active compounds are essential steps in the identification of promising lead compounds for drug development.
Byung-Hak Kim, Soo-Nam Hong, Sang-Kyu Ye, Jung-Youl Park   +3 more
doaj   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Anticancer and antimicrobial activity of methoxy amino chalcone derivatives [PDF]

, 2015
A series of methoxy amino chalcone derivatives have been synthesized and evaluated for their anticancer activity against breast cancer cells line T47D and their antimicrobial activity against Escherichia coli ATCC 25923, Staphylococcus aureus ATCC 25922,
Mustofa, .-, Ni’matuzahroh, .-, Jumina, .-, Ni Nyoman Tri Puspaningsih, .-, Hery Suwito, .-   +4 more
core