Results 61 to 70 of about 33,682 (280)

Evaluation and Optimization of the Anti-Melanogenic Activity of 1-(2-Cyclohexylmethoxy-6-hydroxy-phenyl)-3-(4-hydroxymethyl-phenyl)-propenone Derivatives

Molecules, 2019
The chemical modification and optimization of biologically active compounds are essential steps in the identification of promising lead compounds for drug development.
Byung-Hak Kim, Soo-Nam Hong, Sang-Kyu Ye, Jung-Youl Park   +3 more
doaj   +1 more source

Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.

, 2009
The alpha-methyl chalcone SD400 is a potent inhibitor of tubulin assembly and possesses potent anticancer activity. Various chalcone analogues were synthesized and evaluated for their cell growth inhibitory properties against the K562 human chronic ...
Kendall, A, Lawrence, NJ, Ducki, S, Woo, M, Renninson, D, Mcgown, A   +5 more
core   +1 more source

Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice

Frontiers in Pharmacology, 2018
Gouty arthritis is characterized by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain and reduction in the life quality of patients.
Larissa Staurengo-Ferrari, Kenji W. Ruiz-Miyazawa, Felipe A. Pinho-Ribeiro, Victor Fattori, Tiago H. Zaninelli, Stephanie Badaro-Garcia, Sergio M. Borghi, Thacyana T. Carvalho, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri   +12 more
doaj   +1 more source

Protein–Anthocyanin Interactions in Food Systems: A Reaction‐Network Perspective on Equilibria, Kinetics, and Degradation Pathways

ChemFoodChem, EarlyView.
Protein–anthocyanin interactions are reinterpreted beyond binding affinity through a reaction‐network perspective. Distinct protein classes modulate anthocyanin behavior through equilibrium shifts, matrix‐driven protection, self‐assembly, or covalent conjugation.
E. Mariana Martins, Victor de Freitas, Susana Soares, Joana Oliveira   +3 more
wiley   +1 more source

Tailoring Liquid Crystalline Self‐Assembly and Photophysical Properties of Unsymmetrical Fluorenones via Polar Terminal Groups

Chemistry – A European Journal, EarlyView.
Novel liquid crystalline fluorenones bearing various head groups were synthesized and characterized. By alteration of the head group, N, SmC, or SmA phases were obtained, and emission properties could be tuned depending on solvent or temperature. ABSTRACT In this work, a series of novel unsymmetrical fluorenone derivatives bearing various head groups ...
Falk Feucht, Franziska Müller, Johanna Osterbrink, Anna Zens, Yann Molard, Sabine Laschat   +5 more
wiley   +1 more source

Simple chalcones and bis-chalcones ethers as possible pleiotropic agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015
The synthesis, the antioxidative properties and the lipoxygenase (LOX) and acetylcholinesterase (AChE) inhibition of a number of 4-hydroxy-chalcones diversely substituted as well as of a series of bis-chalcones ether derivatives are reported. The chalcones derivatives were readily produced using a Claisen-Schmidt condensation in a ultra sound bath in ...
Liargkova, T., Hadjipavlou-Litina, D.J., Koukoulitsa, C., Voulgari, E., Avgoustakis, C.   +4 more
openaire   +3 more sources

Identification and isolation of chalcone mutants of Caenorhabditis elegans [PDF]

, 2022
Plant parasitic nematodes (PPNs) cause an enormous annual monetary loss, and traditional methods to control them can harm people and the environment. Previous research identified a safe, effective way to control PPNs using organic chalcone compounds. Two
Arwa Alsubhi
core  

The Expanding Role of Diazirines in Synthetic Methodology

European Journal of Organic Chemistry, EarlyView.
Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic, Dominik Schnalzer, Marko D. Mihovilovic, Michael Schnürch   +3 more
wiley   +1 more source

Development and validation of a UV–Vis spectrophotometric method for estimation of total content of chalcone

MethodsX
In this study, a straightforward spectrophotometric method was developed for quantifying the total content of chalcones in a sample. The method exhibits linearity, accuracy, precision, repeatability, and enables the estimation of total chalcone content ...
J.R.S. Botelho, A. Caeiro, H.C. Sousa, M.E.M. Braga, M.G. Campos   +4 more
doaj   +1 more source

Evaluation of the anti-tumor and immunomodulatory effects of synthetic chalcones in a tumor mouse model [PDF]

Egyptian Journal of Cancer and Biomedical Research, 2019
Introduction: Traditional treatment of cancer by using chemotherapy not only kills cancer cells but also normal cells. It also fails in the complete prevention of the spread of tumor cells. Chalcone have several biological activities, such as antioxidant,
Mohamed Nasef, Mohamed Gaber, Asmaa El Gamal, Mohamed Salem   +3 more
doaj   +1 more source