Results 41 to 50 of about 23,013 (219)

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

Advanced Science, EarlyView.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia   +10 more
wiley   +1 more source

Unveiling the Anticancer Properties of New Synthesized Alkoxy‐ and Methyl Thio‐Chalcone Derivatives

Natural Sciences
Breast and cervical cancers are a serious problem and the leading cause of death in women in this decade. Chalcone is a promising compound with great potential for anticancer use.
Nurcahyo Iman Prakoso, Taiki Umezawa, Dwiarso Rubiyanto, Azizah Zelia Kusumo, Fanny Septianingtyas, Muhamad Ikhsan Nurochman, Laras Kristianti, Salmahaminati, Pinus Jumaryatno, Minori Abe   +9 more
doaj   +1 more source

INVESTIGATION OF ANTICANCER MECHANISMS OF A CHALCONE/XANTHINE HYBRID IN NON-SMALL CELL LUNG CANCER [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Despite major advances in therapy, Lung cancer remains the major cause of death among cancer cases. Chalcone/xanthine Hybrid is a synthetic xanthine derivative that was found to exert an anticancer action in various cancer types.
Omar Elrehany, Al - Shaimaa Ahmed, Hesham Abou-Zied, Alaa Hayallah, Mohamed Abdel-Aziz, Maiiada Nazmy   +5 more
doaj   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Evaluation and Optimization of the Anti-Melanogenic Activity of 1-(2-Cyclohexylmethoxy-6-hydroxy-phenyl)-3-(4-hydroxymethyl-phenyl)-propenone Derivatives

Molecules, 2019
The chemical modification and optimization of biologically active compounds are essential steps in the identification of promising lead compounds for drug development.
Byung-Hak Kim, Soo-Nam Hong, Sang-Kyu Ye, Jung-Youl Park   +3 more
doaj   +1 more source

Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice

Frontiers in Pharmacology, 2018
Gouty arthritis is characterized by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain and reduction in the life quality of patients.
Larissa Staurengo-Ferrari, Kenji W. Ruiz-Miyazawa, Felipe A. Pinho-Ribeiro, Victor Fattori, Tiago H. Zaninelli, Stephanie Badaro-Garcia, Sergio M. Borghi, Thacyana T. Carvalho, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri   +12 more
doaj   +1 more source

Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones

Pharmacology & Pharmacy, 2011
A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. A novel series of pyrazolicchalcones (5a-c) have been synthesized by the reaction of respective chalcones (4a-c) and hydrazine hydrate.
Tan Nhut Doan, Dao Thanh Tran
openaire   +2 more sources

An Intelligent Wound Dressing Platform Based on Natural pH‐Sensors From Syzygium cumini

Journal of Applied Polymer Science, EarlyView.
This study presents a dual‐functionality wound dressing platform based on an alginate–hyaluronate matrix integrated with Syzygium cumini extract. The smart film acts as a sensitive, reversible pH‐sensor for real‐time infection monitoring and a structural plasticizer that enhances mechanical conformability.
Rachel Faverzani Magnago, Felipe da Silva Valente, Jovana Volpato Philippi, Kellen Mar‐con Medeiros, Fernanda Mendes de Moraes, Stefano Caon Tallamini, Marcelo Maraschin, Fernando Dal Pont Morisso, Karine Modolon Zepon   +8 more
wiley   +1 more source

Development and validation of a UV–Vis spectrophotometric method for estimation of total content of chalcone

MethodsX
In this study, a straightforward spectrophotometric method was developed for quantifying the total content of chalcones in a sample. The method exhibits linearity, accuracy, precision, repeatability, and enables the estimation of total chalcone content ...
J.R.S. Botelho, A. Caeiro, H.C. Sousa, M.E.M. Braga, M.G. Campos   +4 more
doaj   +1 more source

Cytotoxic Activity of Methoxy-4’amino Chalcone Derivatives Against Leukemia Cell Lines

MCBS (Molecular and Cellular Biomedical Sciences), 2019
Background: Chemotherapy is a common treatment for leukemia as well as in other cancer treatment. The lack of tumor selectivity and development of multi-drug resistance by chemotherapy caused the development of new strategy in cancer treatment become a ...
Arina Novilla, Mustofa Mustofa, Indwiani Astuti, Jumina Jumina, Hery Suwito   +4 more
doaj   +1 more source