Results 21 to 30 of about 30,495 (265)
A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells
Journal of International Medical Research, 2020 Objective To investigate the in vitro and in vivo anticancer effects of a chalcone against KYSE-4 esophageal cancer cells. Methods A chalcone was synthesized via the molecular hybridization strategy based on the anticancer activity of chalcone and ...
Jie Chen +4 more
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Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition.
PLoS ONE, 2018 Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-
Gabriel Silva +13 more
doaj +1 more source
Molecules, 2023 Chalcones are interesting anticancer drug candidates which have attracted much interest due to their unique structure and their extensive biological activity.
Mahmoud I. M. Darwish +10 more
doaj +1 more source
Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase
Journal of Natural Products, 2023 By mining fungal genomic information, a noncanonical iterative type I PKS fused with an N-terminal adenylation-thiolation didomain, which catalyzes the formation of naringenin chalcone, was found. Structural prediction and molecular docking analysis indicated that a C-terminal thioesterase domain was involved in the Claisen-type cyclization.
Sho Furumura +7 more
openaire +2 more sources
Indonesian Journal of Chemistry, 2018 The synthesis of chalcone derivatives as target compounds and anticancer test against breast (T47D) and colon (WiDr) cell line had been performed.
Chairil Anwar +5 more
doaj +1 more source
Hepatoprotective and antifibrotic effects of trans-chalcone against bile duct ligation-induced liver fibrosis in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Several lines of research have shown that hepatic fibrosis is one of the leading causes of death worldwide. Trans-chalcone is a flavonoid precursor with anti-oxidant and anti-inflammatory effects.
Faezeh Javadi +5 more
doaj +1 more source
Nature Communications, 2020 Chalcone synthase is the first committed enzyme in the plant flavonoid biosynthesis pathway, yet shows low product specificity in vitro. Here Waki et al.
Toshiyuki Waki +20 more
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The Benefits of Chalcone and Its Derivatives as Antibacterial Agents: A Review
BIO Web of Conferences, 2020 Chalcone is a secondary metabolite compound found in plants. Chalcones contain two aryl rings, namely ring A and B which connected to the α,β unsaturated ketones.
Mustikasari Kamilia +1 more
doaj +1 more source
2-Hydroxychalcone as a Potent Compound and Photosensitizer Against Dermatophyte Biofilms
Frontiers in Cellular and Infection Microbiology, 2021 Dermatophytes, fungi that cause dermatophytosis, can invade keratinized tissues in humans and animals. The biofilm-forming ability of these fungi was described recently, and it may be correlated with the long treatment period and common recurrences of ...
Níura Madalena Bila +9 more
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A new member of the chalcone synthase (CHS) family in sugarcane
Genetics and Molecular Biology, 2001 Sequences from the sugarcane expressed sequence tag (SUCEST) database were analyzed based on their identities to genes encoding chalcone-synthase-like enzymes.
Miriam G.G. Contessotto +3 more
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