Results 41 to 50 of about 950 (182)

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie International Edition, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +1 more source

De Novo Design of Imidazopyridine-Tethered Pyrazolines That Target Phosphorylation of STAT3 in Human Breast Cancer Cells

Bioengineering, 2023
In breast cancer (BC), STAT3 is hyperactivated. This study explored the design of imidazopyridine-tethered pyrazolines as a de novo drug strategy for inhibiting STAT3 phosphorylation in human BC cells.
Akshay Ravish, Rashmi Shivakumar, Zhang Xi, Min Hee Yang, Ji-Rui Yang, Ananda Swamynayaka, Omantheswara Nagaraja, Mahendra Madegowda, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Vijay Pandey, Gautam Sethi, Kwang Seok Ahn, Peter E. Lobie, Basappa Basappa   +14 more
doaj   +1 more source

Assessment of insecticide use practices in licensed pest control operators in North Carolina

Pest Management Science, EarlyView.
A statewide survey of 105 licensed North Carolina pesticide operators found ants, mosquitoes, and aphids as top target pests, pyrethroids as the dominant insecticide class (68%), and limited resistance monitoring, establishing a baseline for future insecticide resistance management and outreach.
Kaylin Russell, Stephanie Richards, Sinan Sousan, Jo Anne Balanay   +3 more
wiley   +1 more source

Synthesis and Cytotoxic Evaluation of 3-(4-Fluorophenyl)-4,5-dihydro-5-(3,4,5-trimethoxy/4-nitrophenyl)-N-(substituted-phenyl)pyrazole-1-carboxamide Analogues

SynOpen, 2018
A novel series of 3-(4-fluorophenyl)-4,5-dihydro-5-(3,4,5-trimethoxy/4-nitro phenyl)-N-(substituted-phenyl)pyrazole-1-carboxamide analogues 4a–n was synthesized in two steps from 4-fluoroacetophenone.
Mohamed J. Ahsan, Bhawani S. Kumawat, Sonu Kumawat, Piush Sharma, Mohammad A. Bakht, Mohd Z. Hassan, Afzal Hussain, Pankaj Saraswat, Habibullah Khalilullah   +8 more
doaj   +1 more source

White light emitting molecular logic gates

Smart Molecules, EarlyView.
White light emitting smart molecules with Boolean logic computing ability are surveyed. Abstract White light emitting (WLE) materials are of considerable interest with commercial and societal applications in video displays and lighting devices. A characteristic property of WLE materials is the luminescence profile spanning from 380 to 700 nm.
Davide Benedetto Tiz, Massimo Catania, David C. Magri   +2 more
wiley   +1 more source

Pyrene‐linked heterocyclic pyrazoles: Synthesis, antimicrobial screening, and in silico molecular insights

Smart Molecules, EarlyView.
A series of novel pyrene‐linked heterocyclic pyrazoles were synthesized and structurally characterized. The compounds were evaluated for antimicrobial activity against selected bacterial and fungal strains, showing promising inhibitory effects. Molecular docking studies provided insights into binding interactions and structure–activity relationships ...
Dinkal V. Kasundra, Paresh N. Patel
wiley   +1 more source

Pyrazoline as a medicinal scaffold [PDF]

Bionatura, 2019
Heterocyclic Chemistry is the backbone of medicinal compounds that exhibits numerous biological activities. Pyrazole and its derivatives possess nitrogen atom along with carbon atom as a substitution and show a diversity of biological activities such as antibacterial, antimicrobial, anti-inflammatory, antioxidant, antidiabetic, anticancer, antifungal ...
Gurinderdeep Singh, Anju Goyal, R S Bhatti, Sandeep Arora   +3 more
openaire   +1 more source

A Study of Antioxidant Properties and a Pharmacokinetic Investigation of Chalcones and Pyrazolines

Orbital: The Electronic Journal of Chemistry
Antioxidant compounds are widely studied in the literature because they minimize oxidative damage in biological processes. In this context, chalcones and pyrazolines are considered prototype compounds for this purpose. This study describes the synthesis
André Luis Kerek, Larissa Kozan , Gabrielle Schamne Fonseca , Bianca Sartori dos Santos , Raphaela Pereira Guaringue , Larissa Sens, Barbara Celânia Fiorin   +6 more
doaj   +1 more source

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

Applied Sciences, 2013
A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and ...
Manuel Nogueras, Jairo Quiroga, Justo Cobo, Efraín Polo, Jorge Trilleras   +4 more
doaj   +1 more source

Recent Advances in Chemosensors Bearing Pyrazole and Imidazole Rings: An Approach Toward the Detection of Metal Ions Based on these Diazoles

Advanced Sensor Research, Volume 5, Issue 10, October 2026.
This contribution analyzes recent articles (2021–2025) on chemosensors containing pyrazole and imidazole rings for detecting metal ions, using distinctive examples. It focuses on the structural design of probes, their coordination behavior, sensing mechanisms, and analytical performance, including selectivity, sensitivity, working wavelength, and ...
Alexander Ladino‐Bejarano, Carlos Cifuentes, Néstor Bravo, Jaime Portilla   +3 more
wiley   +1 more source