Results 41 to 50 of about 928 (176)

A Study of Antioxidant Properties and a Pharmacokinetic Investigation of Chalcones and Pyrazolines

Orbital: The Electronic Journal of Chemistry
Antioxidant compounds are widely studied in the literature because they minimize oxidative damage in biological processes. In this context, chalcones and pyrazolines are considered prototype compounds for this purpose. This study describes the synthesis
André Luis Kerek, Larissa Kozan , Gabrielle Schamne Fonseca , Bianca Sartori dos Santos , Raphaela Pereira Guaringue , Larissa Sens, Barbara Celânia Fiorin   +6 more
doaj   +1 more source

Synthesis and Anti‐Inflammatory Activity of Pyrazolines [PDF]

Journal of Chemistry, 2009
Some new pyrazoline derivatives were synthesized by reacting chalcones of 2‐acetyl thiophene with phenyl hydrazine hydrochloride in the presence of alcohol. The synthesized compounds were identified by spectral data and screened for anti‐inflammatory activity. Some of these compounds showed moderate to considerable anti‐inflammatory activity.
B. Ramesh, T. Sumana
openaire   +2 more sources

Acetylcholinesterase inhibitory potencies of new pyrazoline derivatives [PDF]

Journal of Research in Pharmacy, 2020
Alzheimer's disease (AD) has no current cure and its mechanism is not fully known, but treatments for symptoms are available. Acetylcholinesterase (AChE) has been reported to be an applicable therapeutic target in patient with AD. Acetylcholinesterase inhibitors (AChEIs) are commonly used for it.
Tuğrak Sakarya, Mehtap, Gül, Halise İnci, Gülçin, İlhami   +2 more
openaire   +4 more sources

Photochemical Synthesis of Pyrazolines from Tetrazoles in Flow

SynOpen, 2023
Pyrazolines and their pyrazole congeners are important heterocyclic building blocks with numerous applications in the fine chemical industries. However, traditional routes towards these entities are based on multistep syntheses generating substantial ...
Adam Burke, Silvia Spiccio, Mara Di Filippo, Marcus Baumann   +3 more
doaj   +1 more source

1,2‐Diazetidines − Structure, Synthesis, and Functionalization

European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.
1,2‐Diazetidines are saturated four‐membered heterocycles featuring two adjacent nitrogen atoms. Despite recent advances in their synthesis and promising potential in medicinal chemistry, the chemistry of these cyclic hydrazines remains underexplored.
Stefan Roesner
wiley   +1 more source

Quantification of Specific Urinary Oligosaccharide Biomarkers for Diagnosis and Treatment Monitoring of Alpha‐Mannosidosis

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Alpha‐mannosidosis (AM, OMIM# 248500), an ultra‐rare lysosomal storage disorder (LSD), is caused by insufficient activity of alpha‐mannosidase, an enzyme involved in degradation of N‐glycan oligosaccharides. Hence, specific oligosaccharides accumulate in tissues, resulting in a progressive multi‐organ disease.
Dominik Dörfel, Benjamin Dreyer, Mona Lindschau, Antonio Barbato, Nadia Altavilla, Giancarlo la Marca, Lara Maleen Marten, Friederike Bürger, Mara Botti, Lina Verena Sevenich, Ronen Spiegel, Anke Schumann, Melanie Herrmann, Davor Fielitz, Nicole Muschol, René Santer, Simona Murko   +16 more
wiley   +1 more source

SOCl2 catalyzed cyclization of chalcones: Synthesis and spectral studies of some bio-potent 1H pyrazoles

Bulletin of the Chemical Society of Ethiopia, 2014
Some aryl-aryl 1H pyrazoles have been synthesised by cyclization of aryl chalcones and hydrazine hydrate in the presence of SOCl2. The yields of the pyrazoles are more than 85%.
K. Ranganathan, R. Suresh, G. Vanangamudi, K. Thirumurthy, P. Mayavel, G. Thirunarayanan   +5 more
doaj   +1 more source

Uniqueness of Supramolecular Systems

Macromolecular Materials and Engineering, Volume 311, Issue 5, May 2026.
Thanks to the variety of classes of supramolecular systems, they have been widely used in various applications. For example, in sensing devices, catalysis, and biomedicine. An example of a conventional photovoltaic material converted into electrical energy. Selective UV or NIR absorbers are required to produce materials with low or no coloration.
José A. Sánchez‐Fernández
wiley   +1 more source

Synthesis of enones, pyrazolines and pyrrolines with gem-difluoroalkyl side chains

Beilstein Journal of Organic Chemistry, 2013
Starting from easily accessible gem-difluoropropargylic derivatives, a DBU-mediated isomerisation affords enones in fair yields with a gem-difluoroalkyl chain.
Assaad Nasr El Dine, Ali Khalaf, Danielle Grée, Olivier Tasseau, Fares Fares, Nada Jaber, Philippe Lesot, Ali Hachem, René Grée   +8 more
doaj   +1 more source

Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich, Martin Ullrich, Cathleen Haase‐Kohn, Robert Wodtke, Sebastian Braun, Maximilian Molitor, Bettina Hofmann, Dieter Steinhilber, Klaus Kopka, Evamarie Hey‐Hawkins, Jens Pietzsch, Markus Laube   +11 more
wiley   +1 more source