Results 51 to 60 of about 929 (177)

Antinociceptive effect of novel pyrazolines in mice

Brazilian Journal of Medical and Biological Research, 2004
The antinociceptive effect of six novel synthetic pyrazolines (3-ethoxymethyl-5-ethoxycarbonyl-1H-pyrazole (Pz 1) and its corresponding 1-substituted methyl (Pz 2) and phenyl (Pz 3) analogues, and 3-(1-ethoxyethyl)-5-ethoxycarbonyl-1H-pyrazole (Pz 4) and
Z. Tabarelli, M.A. Rubin, D.B. Berlese, P.D. Sauzem, T.P. Missio, M.V. Teixeira, A.P. Sinhorin, M.A.P. Martins, N. Zanatta, H.G. Bonacorso, C.F. Mello   +10 more
doaj   +1 more source

Synthesis of New Pyrazolines Derivatives from Coumarine Compounds [PDF]

مجلة التربية والعلم, 1999
The present work includes preparation of series of chalcones and condensation of these chalcones with a series of prepared coumarin hydrazides in acidic medium to afford the new pyrazolines.
W. Gh-Bedewy, O. Salih, A. Ahmad
doaj   +1 more source

Photochemical Synthesis of Pyrazolines from Tetrazoles in Flow

SynOpen, 2023
Pyrazolines and their pyrazole congeners are important heterocyclic building blocks with numerous applications in the fine chemical industries. However, traditional routes towards these entities are based on multistep syntheses generating substantial ...
Adam Burke, Silvia Spiccio, Mara Di Filippo, Marcus Baumann   +3 more
doaj   +1 more source

Electrochemically enabled oxidative aromatization of pyrazolines

Organic & Biomolecular Chemistry, 2023
Electrochemical oxidation of pyrazolines mediated by ubiquitous sodium chloride readily enables access to a broad variety of pyrazoles in a sustainable manner.
Silja Hofmann, Martin Linden, Julian Neuner, Felix N. Weber, Siegfried R. Waldvogel   +4 more
openaire   +4 more sources

Purine and Pyrrolopyrimidine‐Based Small Molecules as Multitarget Therapeutics

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Purine and pyrrolopyrimidine scaffolds target multiple oncogenic pathways: cyan kinases (VEGFR‐2, Aurora A, JAK2); red epigenetic/chaperone regulators (HDAC6, BRD4, Hsp90); blue efflux and signaling/sensory modulators (MRP1, PDE, TLR, TRPA1); yellow folate‐pathway enzymes (TS, DHFR, GARFTase), defining a dual‐scaffold platform for multi‐target ...
Federica Borghi, Antonio Laus, Claudia Sorbi, Giulio Rastelli   +3 more
wiley   +1 more source

Cytotoxic potential of novel N-formyl pyrazolines derived from vanillin [PDF]

Kragujevac Journal of Science
In the reaction of vanillin and acetone under Claisen-Schmidt conditions, dehydrozingerone, a very attractive biologically active compound, is obtained.
Muškinja Jovana M., Marković Violeta R., Todorović Tamara Lj, Luković Jovan D., Nikolić Ivana S., Mitrović Marina M., Ratković Zoran R.   +6 more
doaj   +1 more source

1,2‐Diazetidines − Structure, Synthesis, and Functionalization

European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.
1,2‐Diazetidines are saturated four‐membered heterocycles featuring two adjacent nitrogen atoms. Despite recent advances in their synthesis and promising potential in medicinal chemistry, the chemistry of these cyclic hydrazines remains underexplored.
Stefan Roesner
wiley   +1 more source

Quantification of Specific Urinary Oligosaccharide Biomarkers for Diagnosis and Treatment Monitoring of Alpha‐Mannosidosis

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Alpha‐mannosidosis (AM, OMIM# 248500), an ultra‐rare lysosomal storage disorder (LSD), is caused by insufficient activity of alpha‐mannosidase, an enzyme involved in degradation of N‐glycan oligosaccharides. Hence, specific oligosaccharides accumulate in tissues, resulting in a progressive multi‐organ disease.
Dominik Dörfel, Benjamin Dreyer, Mona Lindschau, Antonio Barbato, Nadia Altavilla, Giancarlo la Marca, Lara Maleen Marten, Friederike Bürger, Mara Botti, Lina Verena Sevenich, Ronen Spiegel, Anke Schumann, Melanie Herrmann, Davor Fielitz, Nicole Muschol, René Santer, Simona Murko   +16 more
wiley   +1 more source

Uniqueness of Supramolecular Systems

Macromolecular Materials and Engineering, Volume 311, Issue 5, May 2026.
Thanks to the variety of classes of supramolecular systems, they have been widely used in various applications. For example, in sensing devices, catalysis, and biomedicine. An example of a conventional photovoltaic material converted into electrical energy. Selective UV or NIR absorbers are required to produce materials with low or no coloration.
José A. Sánchez‐Fernández
wiley   +1 more source

Multifaceted Anticancer Activity of Flavanone/Chromanone Intermediates for Five-Membered Heterocyclic Derivatives: Targeting Oxidative Stress, Apoptosis, and MAPK Signaling in Colorectal Cancer

Molecules
This study explores the multifaceted anticancer mechanisms of flavanone analogues and spiropyrazoline condensed with flavanone ring against colorectal cancer (CRC) cell lines.
Pawel Hikisz, Angelika A. Adamus-Grabicka, Elzbieta Budzisz   +2 more
doaj   +1 more source