Results 61 to 70 of about 929 (177)

Synthesis and in Vitro Antimicrobial Activity of Some Pyrazolyl-1-carboxamide Derivatives

Molecules, 2011
A series of 3,5-disubstituted pyrazole-1-carboxamides were obtained by treatment of chalcones with semicarbazide hydrochloride in dioxane containing sodium acetate/acetic acid as a buffer solution.
Essam Mohamed Sharshira, Nagwa Mohamed Mahrous Hamada   +1 more
doaj   +1 more source

Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich, Martin Ullrich, Cathleen Haase‐Kohn, Robert Wodtke, Sebastian Braun, Maximilian Molitor, Bettina Hofmann, Dieter Steinhilber, Klaus Kopka, Evamarie Hey‐Hawkins, Jens Pietzsch, Markus Laube   +11 more
wiley   +1 more source

Recent Advances in Carbonyl–Olefin and Carbonyl–Alkyne Metathesis Reactions

ChemistryEurope, Volume 4, Issue 4, April 2026.
Carbonyl–olefin and carbonyl–alkyne metathesis enable atom‐economic C–C bond formation beyond classical olefin metathesis. This review highlights recent advances in photochemical, Lewis‐acid, Brønsted‐acid, and organocatalytic strategies, mechanistic insights, and synthetic applications, showcasing carbonyl metathesis as a versatile platform for modern
Komal Kalonia, Ramees Komath, Martin Breugst   +2 more
wiley   +1 more source

Unveiling the Anticancer Properties of New Synthesized Alkoxy‐ and Methyl Thio‐Chalcone Derivatives

Natural Sciences, Volume 6, Issue 2, April 2026.
ABSTRACT Breast and cervical cancers are a serious problem and the leading cause of death in women in this decade. Chalcone is a promising compound with great potential for anticancer use. In this work, we synthesized six chalcone derivatives with alkoxy‐ and methylthio‐substituents through Claisen–Schmidt condensation at room temperature.
Nurcahyo Iman Prakoso, Taiki Umezawa, Dwiarso Rubiyanto, Azizah Zelia Kusumo, Fanny Septianingtyas, Muhamad Ikhsan Nurochman, Laras Kristianti, Salmahaminati, Pinus Jumaryatno, Minori Abe   +9 more
wiley   +1 more source

Pyrazoline Derivatives: Synthesis, In Silico, Enzyme Kinetics Studies and Biological Activity against Cholinesterase, Lipoxygenase, and α‐Amylase

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Nucleophilic cyclization of the α, β‐unsaturated carbonyl framework of the prepared (E)‐4‐(3‐bromo‐4‐hydroxy‐5‐methoxyphenyl)but‐3‐en‐2‐one with various hydrazine derivatives to afford their corresponding pyrazolines has been achieved. The enzyme assays conducted showed significant α‐amylase inhibitory activity for 4b with IC50 value of 2.7 µM.
Redolf S. Segodi, E. N. Agbo, Leoma B. Mofeli, K. W. Poopedi, O. O. Oderinlo, W. Nxumalo   +5 more
wiley   +1 more source

SYNTHESIS AND CHARACTERIZATION OF [(5-MERCAPTO-1,3,4-OXADIAZOL-2-YL)ARYL]-3,5-DIARYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOTHIOAMIDES [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2011
The synthesis and characterization of [(5-mercapto-1,3,4-oxadiazol-2-yl)aryl]-3,5-diaryl-4,5-dihydro-1Hpyrazole-1-carbothioamides - derivatives of pyrazolines and 5-[4(3)-isothiocyanatophenyl]-2-thio-1,3,4-oxadiazoles were realized.
Zinaida Ribkovskaia, Serghei Pogrebnoi, Alic Barba, Fliur Macaev   +3 more
doaj  

Easier, Safer, and Greener: Unlocking the Power of Solid Reagents in Organic Reactions by Mechanochemistry

ChemistryEurope, Volume 4, Issue 2, February 2026.
This review highlights the powerful synergy between mechanochemistry and solid reagents to replace hazardous substances traditionally used in organic synthesis. Such an approach offers a safer and more sustainable pathway for conducting organic reactions, with potential benefits in both reactivity and selectivity. The use of solid bases, acids, and gas
Adrien Gallego, Nicolas Pétry, Julien Pinaud, Olivia Giani, Frédéric Lamaty   +4 more
wiley   +1 more source

Reactivity of 4-tert-Butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with Hydrazines

Molecules, 2006
The reactivity of 6-(nitrophenyl or trimethoxyphenyl)-4-tert-butyldimethyl- siloxy-1,2,3,6-tetrahydropyridine derivatives with hydrazines under acid conditions is described.
Manuel Medarde, Fernando Tomé, Pilar Puebla, Esther Caballero, Javier Figueroa   +4 more
doaj   +1 more source

A Convenient and Efficient Protocol for the Synthesis of 1,3,5-Triaryl-2-pyrazolines in Acetic Acid under Ultrasound Irradiation

E-Journal of Chemistry, 2012
1,3,5-Triaryl-2-pyrazolines were synthesized in acetic acid in high yields within 60-180 min under ultrasound irradiation at room temperature.
Zhi-Ping Lin, Ji-Tai Li
doaj   +1 more source

Secosteroid–2-Pyrazoline Hybrids: Design, Synthesis, Biological Evaluation and Development of Therapeutic Combinations Against ERα-Positive Breast Cancer Cells

Biomedicines
Background/Objectives: Breast cancer remains one of the most prevalent and life-threatening malignancies worldwide. This study describes the design and biological evaluation of a series of secosteroid–2-pyrazoline hybrids as novel antitumor agents ...
Alexey I. Ilovaisky, Alexander M. Scherbakov, Fedor B. Bogdanov, Dumitru Miciurov, Elena I. Chernoburova, Valentina M. Merkulova, Eugene I. Bozhenko, Andrey S. Dmitrenok, Diana I. Salnikova, Danila V. Sorokin, Alvina I. Khamidullina, Mikhail A. Krasil’nikov, Igor V. Zavarzin, Alexander O. Terent’ev   +13 more
doaj   +1 more source