Results 61 to 70 of about 928 (176)

Coumarin‐Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Compound 13, a coumarin‐thiazole hybrid, is shown engaging the ATP‐binding site of S. aureus GyrB through a novel hydrogen bond with residue SER129. The molecule exhibits dual antibacterial and anticancer activity, supporting its potential as a dual‐target topoisomerase inhibitor.
Islam K. Matar, Magdi E. A. Zaki, Zeinab A. Muhammad, Dahlia A. Awwad, Sami A. Al‐Hussain, Chérif F. Matta, Refaie M. Kassab   +6 more
wiley   +1 more source

Synthesis of a novel series of chalcones and pyrazolines, possessing indole with 4-(2,2,2-trifluroethoxy) pyridine moiety

Orbital: The Electronic Journal of Chemistry, 2012
A new method for the construction of novel fluorine-containing indole ring system has been reported. These indoles were converted into a new series of fluorine-containing indolyl chalcones (1a-g) and pyrazolines (2a-g). All the newly synthesized
Mazahar Farooqui, Nasir Ali Shafakat Ali, Afzal Yosuf Khan   +2 more
doaj   +1 more source

Anti‐Arthritic Potential of Pyrazoline Derivative Against Complete Freund's Adjuvant Induced Arthritis in Rats

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT This research explored the potential of a synthesised pyrazoline derivative 5‐ethoxy 5‐hydroxy 3‐methyls 4, 5‐dihydro 1Hpyrazol 1 yl (pyridine 4 yl) methanone [5‐E‐5‐H‐PD], against arthritis using a Complete Freund's Adjuvant (CFA)‐induced arthritis in a rat model.
Jian Li, Irfan Anjum, Halima Qadir, Faiza Naseer, Mehreen Arif, Muhammad Riaz, Rabia Gul, Madiha Kanwal, Bei Zhuang   +8 more
wiley   +1 more source

Mesoionische N‐Heterocyclische Olefine, Imine, Thione, Phosphinidene und ihre Anwendung in der Katalyse

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
Dieser Mini‐Review behandelt die neuesten Fortschritte bei der Synthese, Reaktivität und metallfreien katalytischen Verwendung von mesoionischen N‐heterocyclischen Olefinen (mNHOs), Iminen (mNHIs), Thionen (mNHTs) und Phosphinidenen (mNHPs). Kurzzusammenfassung Übergangsmetallverbindungen sind allgemein für ihre Fähigkeit bekannt, kleine Moleküle zu ...
Subir Maji, Sreejyothi P., Max M. Hansmann, Swadhin K. Mandal   +3 more
wiley   +1 more source

Matrix Metalloproteinase Inhibition in Melanoma

Experimental Dermatology, Volume 35, Issue 1, January 2026.
ABSTRACT Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix (ECM) and are found to participate in all stages of tumour progression including modifying signalling pathways, regulating cytokines and promoting tumour growth, particularly by inducing angiogenesis and facilitating cancer spread.
Ellie Zhang, Varsha Thakur, Barbara Bedogni   +2 more
wiley   +1 more source

Cytotoxic potential of novel N-formyl pyrazolines derived from vanillin [PDF]

Kragujevac Journal of Science
In the reaction of vanillin and acetone under Claisen-Schmidt conditions, dehydrozingerone, a very attractive biologically active compound, is obtained.
Muškinja Jovana M., Marković Violeta R., Todorović Tamara Lj, Luković Jovan D., Nikolić Ivana S., Mitrović Marina M., Ratković Zoran R.   +6 more
doaj   +1 more source

Schiff Base–Derived Colorimetric Chemosensor for Fe3+ Detection: Synthesis, Mechanistic Insights, and Real‐World Applications in Water Quality Monitoring

International Journal of Analytical Chemistry, Volume 2026, Issue 1, 2026.
A Schiff base colorimetric chemosensor (H2L), synthesized from 2‐hydroxy‐1‐naphthaldehyde and anthranilic acid, was developed for selective Fe3+ detection. In a DMF:H2O (9:1, v/v) medium, H2L exhibited a distinct and selective response to Fe3+ among common competing cations, producing a visible color change from yellow to black and a new broad ...
Shahad Ayed Alahmady, Syed Nazreen, Ali Q. Alorabi, Bewketu Mehari   +3 more
wiley   +1 more source

Multifaceted Anticancer Activity of Flavanone/Chromanone Intermediates for Five-Membered Heterocyclic Derivatives: Targeting Oxidative Stress, Apoptosis, and MAPK Signaling in Colorectal Cancer

Molecules
This study explores the multifaceted anticancer mechanisms of flavanone analogues and spiropyrazoline condensed with flavanone ring against colorectal cancer (CRC) cell lines.
Pawel Hikisz, Angelika A. Adamus-Grabicka, Elzbieta Budzisz   +2 more
doaj   +1 more source

Synthesis and in Vitro Antimicrobial Activity of Some Pyrazolyl-1-carboxamide Derivatives

Molecules, 2011
A series of 3,5-disubstituted pyrazole-1-carboxamides were obtained by treatment of chalcones with semicarbazide hydrochloride in dioxane containing sodium acetate/acetic acid as a buffer solution.
Essam Mohamed Sharshira, Nagwa Mohamed Mahrous Hamada   +1 more
doaj   +1 more source

SYNTHESIS AND CHARACTERIZATION OF [(5-MERCAPTO-1,3,4-OXADIAZOL-2-YL)ARYL]-3,5-DIARYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOTHIOAMIDES [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2011
The synthesis and characterization of [(5-mercapto-1,3,4-oxadiazol-2-yl)aryl]-3,5-diaryl-4,5-dihydro-1Hpyrazole-1-carbothioamides - derivatives of pyrazolines and 5-[4(3)-isothiocyanatophenyl]-2-thio-1,3,4-oxadiazoles were realized.
Zinaida Ribkovskaia, Serghei Pogrebnoi, Alic Barba, Fliur Macaev   +3 more
doaj