Results 61 to 70 of about 950 (182)

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

Synthesis and Anti‐Inflammatory Activity of Pyrazolines [PDF]

open access: yesJournal of Chemistry, 2009
Some new pyrazoline derivatives were synthesized by reacting chalcones of 2‐acetyl thiophene with phenyl hydrazine hydrochloride in the presence of alcohol. The synthesized compounds were identified by spectral data and screened for anti‐inflammatory activity. Some of these compounds showed moderate to considerable anti‐inflammatory activity.
B. Ramesh, T. Sumana
openaire   +2 more sources

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer   +6 more
wiley   +1 more source

Light‐Controlled Peptide Self‐Assembly: From Physicochemical Principles to Emerging Biomedical Applications

open access: yesAggregate, Volume 7, Issue 6, June 2026.
This review surveys recent advances in light‐controlled peptide self‐assembly for the design of smart soft matter. It summarizes the underlying physicochemical principles, including thermodynamic control for reshaping free‐energy landscapes, and nonequilibrium control to produce kinetically trapped states and dissipative structures.
Lidong Chen   +7 more
wiley   +1 more source

SYNTHESIS AND CHARACTERIZATION OF [(5-MERCAPTO-1,3,4-OXADIAZOL-2-YL)ARYL]-3,5-DIARYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOTHIOAMIDES [PDF]

open access: yesChemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2011
The synthesis and characterization of [(5-mercapto-1,3,4-oxadiazol-2-yl)aryl]-3,5-diaryl-4,5-dihydro-1Hpyrazole-1-carbothioamides - derivatives of pyrazolines and 5-[4(3)-isothiocyanatophenyl]-2-thio-1,3,4-oxadiazoles were realized.
Zinaida Ribkovskaia   +3 more
doaj  

Reactivity of 4-tert-Butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with Hydrazines

open access: yesMolecules, 2006
The reactivity of 6-(nitrophenyl or trimethoxyphenyl)-4-tert-butyldimethyl- siloxy-1,2,3,6-tetrahydropyridine derivatives with hydrazines under acid conditions is described.
Manuel Medarde   +4 more
doaj   +1 more source

Antinociceptive effect of novel pyrazolines in mice

open access: yesBrazilian Journal of Medical and Biological Research, 2004
The antinociceptive effect of six novel synthetic pyrazolines (3-ethoxymethyl-5-ethoxycarbonyl-1H-pyrazole (Pz 1) and its corresponding 1-substituted methyl (Pz 2) and phenyl (Pz 3) analogues, and 3-(1-ethoxyethyl)-5-ethoxycarbonyl-1H-pyrazole (Pz 4) and
Z. Tabarelli   +10 more
doaj   +1 more source

A Convenient and Efficient Protocol for the Synthesis of 1,3,5-Triaryl-2-pyrazolines in Acetic Acid under Ultrasound Irradiation

open access: yesE-Journal of Chemistry, 2012
1,3,5-Triaryl-2-pyrazolines were synthesized in acetic acid in high yields within 60-180 min under ultrasound irradiation at room temperature.
Zhi-Ping Lin, Ji-Tai Li
doaj   +1 more source

An improved synthesis of 1,3,5-triaryl-2-pyrazolines in acetic acid aqueous solution under ultrasound irradiation

open access: yesBeilstein Journal of Organic Chemistry, 2007
BackgroundPyrazoline derivatives have been found to possess a broad spectrum of biological activities. Among various pyrazoline derivatives, 2-pyrazolines seem to be the most frequently studied. A variety of methods have been reported for the preparation
Ji-Tai Li, Xiao-Hui Zhang, Zhi-Ping Lin
doaj   +1 more source

Secosteroid–2-Pyrazoline Hybrids: Design, Synthesis, Biological Evaluation and Development of Therapeutic Combinations Against ERα-Positive Breast Cancer Cells

open access: yesBiomedicines
Background/Objectives: Breast cancer remains one of the most prevalent and life-threatening malignancies worldwide. This study describes the design and biological evaluation of a series of secosteroid–2-pyrazoline hybrids as novel antitumor agents ...
Alexey I. Ilovaisky   +13 more
doaj   +1 more source

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