Results 151 to 160 of about 12,753,193 (203)

Preparation and antiinflammatory activity of 2- and 4-pyridones

Journal of Medicinal Chemistry, 1982
Several N-alkyl- and N-arylacetoacetamides have been self-condensed to form pyridones. N-Alkylacetoacetamides give 2-pyridones, while N-arylacetoacetamides give 4-pyridones. In an attempt to develop nonacidic, nonsteroidal antiinflammatory agents, the pyridones were tested in a carrageenan-induced pedal edema assay in rats.
J B, Pierce, Z S, Ariyan, G S, Ovenden
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ChemInform Abstract: ACYLATION OF 4‐PYRIDONE

Chemischer Informationsdienst, 1980
AbstractBei der Acylierung von 4‐Pyridon (I) mit aliphatischen Carbonsäure‐anhydriden und ‐chloriden oder freien Säuren in Gegenwart von Dicyclohexylcarbodiimid erhält man ausschließlich die N‐Acyl‐4‐pyridone (III).
F. EFFENBERGER, A. O. + MUECK, E. BESSEY
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Two polymorphs of anhydrous 4-pyridone at 100 K

Acta Crystallographica Section C Crystal Structure Communications, 2008
Two polymorphs of the title compound, C(5)H(5)NO, (I), have been obtained from ethanol. One polymorph crystallizes in the monoclinic space group C2/c [henceforth (I)-M], while the other crystallizes in the orthorhombic space group Pbca [henceforth (I)-O]. In the two forms, the lattice parameters, cell volume and packing motifs are very similar.
Aleksandra, Tyl, Maria, Nowak, Joachim, Kusz   +2 more
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Synthesis, solvatochromic properties and antimicrobial activities of some novel pyridone-based disperse disazo dyes

Journal of Molecular Liquids, 2013
In this study, 5-amino-4-arylazo-3-methyl-1H-pyrazoles (2a-l) were diazotized and coupled with 3-cyano-6-hydroxy-4-methyl-2-pyridone to give pyridone-based disperse disazo dyes (3a-l). The newly synthesized twelve pyridone-based disperse disazo dyes were
Aykut Demirçali, Mustafa Yamaç
exaly   +2 more sources

Synthetic Applications of Chiral 2,3‐Dihydro‐4‐pyridones

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Sajan, Joseph, Daniel L, Comins
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A facile synthesis of novel tricyclic 4-pyridones

Tetrahedron Letters, 2014
Abstract A new and efficient synthesis of tricyclic 4-pyridone analogs through the intramolecular Heck coupling cyclization was described. This reaction features mild conditions and good functional group tolerance allowing for the preparation of several novel tricyclic 4-pyridone analogs.
Buzhe Xu, Zhanling Cheng, Lei Fu
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INFRARED SPECTRA OF COMPLEXES OF 4-PYRIDONES

Canadian Journal of Chemistry, 1963
The infrared spectra of many complexes of Lewis acids with some 4-pyridones have been recorded. Large shifts to lower frequencies of about 100 cm−1 have been observed in a band near 1560 cm−1 as the Lewis acid strength increased. Much smaller shifts of about 5 to 10 cm−1 in a band near 1640 cm−1 were noted.
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Cephalosporin derivatives with 2- and 4-pyridone groups at carbon-3

Journal of Medicinal Chemistry, 1979
Two compounds, analogues of cephalexin with 2- and 4-pyridone groups at C-3, were prepared. Biological evaluation found the compounds to exhibit activity against Gram-positive and Gram-negative organisms in vitro and in vivo. The compounds were only active in vivo on subcutaneous administration.
M L, Edwards, R C, Erickson
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Synthesis and Structure–Activity Relationships of 4-Pyridones as Potential Antimalarials

Journal of Medicinal Chemistry, 2008
A series of diaryl ether substituted 4-pyridones have been identified as having potent antimalarial activity superior to that of chloroquine against Plasmodium falciparum in vitro and murine Plasmodium yoelii in vivo. These were derived from the anticoccidial drug clopidol through a systematic study of the effects of varying the side chain on activity.
Clive L, Yeates, John F, Batchelor, Edward C, Capon, Neil J, Cheesman, Mitch, Fry, Alan T, Hudson, Mary, Pudney, Helen, Trimming, James, Woolven, José M, Bueno, Jesús, Chicharro, Esther, Fernández, José M, Fiandor, Domingo, Gargallo-Viola, Federico, Gómez de las Heras, Esperanza, Herreros, María L, León   +16 more
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Potent antimalarial 4-pyridones with improved physico-chemical properties

Bioorganic & Medicinal Chemistry Letters, 2011
Antimalarial 4-pyridones are a novel class of inhibitors of the plasmodial mitochondrial electron transport chain targeting Cytochrome bc1 (complex III). In general, the most potent 4-pyridones are lipophilic molecules with poor solubility in aqueous media and low oral bioavailability in pre-clinical species from the solid dosage form.
José M, Bueno, Pilar, Manzano, María C, García, Jesús, Chicharro, Margarita, Puente, Milagros, Lorenzo, Adolfo, García, Santiago, Ferrer, Rubén M, Gómez, María T, Fraile, José L, Lavandera, José M, Fiandor, Jaume, Vidal, Esperanza, Herreros, Domingo, Gargallo-Viola   +14 more
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