Results 161 to 170 of about 9,299,574 (208)

Synthesis of Some N-dialkylaminoalkyl-4-pyridones

Journal of the American Pharmaceutical Association (Scientific ed.), 1950
Attempts to prepare some N-dialkylaminoalkyl-4-alkoxy- and 4-aryloxy-2-pyridones by oxidation of N-dialkylaminoalkyl-4-alkoxy- and 4-aryloxy-pyridinium halides with potassium ferricyanide in alkaline solution resulted instead in the formation of N-dialkylaminoalkyl-4-pyridones as a result of cleavage of the 4-alkoxy or 4-aryloxy group under the ...
J H, SHINKAI, L M, PARKS
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Two polymorphs of anhydrous 4-pyridone at 100 K

Acta Crystallographica Section C Crystal Structure Communications, 2008
Two polymorphs of the title compound, C(5)H(5)NO, (I), have been obtained from ethanol. One polymorph crystallizes in the monoclinic space group C2/c [henceforth (I)-M], while the other crystallizes in the orthorhombic space group Pbca [henceforth (I)-O]. In the two forms, the lattice parameters, cell volume and packing motifs are very similar.
Aleksandra, Tyl, Maria, Nowak, Joachim, Kusz   +2 more
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Synthetic Applications of Chiral 2,3‐Dihydro‐4‐pyridones

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Sajan, Joseph, Daniel L, Comins
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A facile synthesis of novel tricyclic 4-pyridones

Tetrahedron Letters, 2014
Abstract A new and efficient synthesis of tricyclic 4-pyridone analogs through the intramolecular Heck coupling cyclization was described. This reaction features mild conditions and good functional group tolerance allowing for the preparation of several novel tricyclic 4-pyridone analogs.
Buzhe Xu, Zhanling Cheng, Lei Fu
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Synthesis and Structure–Activity Relationships of 4-Pyridones as Potential Antimalarials

Journal of Medicinal Chemistry, 2008
A series of diaryl ether substituted 4-pyridones have been identified as having potent antimalarial activity superior to that of chloroquine against Plasmodium falciparum in vitro and murine Plasmodium yoelii in vivo. These were derived from the anticoccidial drug clopidol through a systematic study of the effects of varying the side chain on activity.
Clive L, Yeates, John F, Batchelor, Edward C, Capon, Neil J, Cheesman, Mitch, Fry, Alan T, Hudson, Mary, Pudney, Helen, Trimming, James, Woolven, José M, Bueno, Jesús, Chicharro, Esther, Fernández, José M, Fiandor, Domingo, Gargallo-Viola, Federico, Gómez de las Heras, Esperanza, Herreros, María L, León   +16 more
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Potent antimalarial 4-pyridones with improved physico-chemical properties

Bioorganic & Medicinal Chemistry Letters, 2011
Antimalarial 4-pyridones are a novel class of inhibitors of the plasmodial mitochondrial electron transport chain targeting Cytochrome bc1 (complex III). In general, the most potent 4-pyridones are lipophilic molecules with poor solubility in aqueous media and low oral bioavailability in pre-clinical species from the solid dosage form.
José M, Bueno, Pilar, Manzano, María C, García, Jesús, Chicharro, Margarita, Puente, Milagros, Lorenzo, Adolfo, García, Santiago, Ferrer, Rubén M, Gómez, María T, Fraile, José L, Lavandera, José M, Fiandor, Jaume, Vidal, Esperanza, Herreros, Domingo, Gargallo-Viola   +14 more
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Cephalosporin derivatives with 2- and 4-pyridone groups at carbon-3

Journal of Medicinal Chemistry, 1979
Two compounds, analogues of cephalexin with 2- and 4-pyridone groups at C-3, were prepared. Biological evaluation found the compounds to exhibit activity against Gram-positive and Gram-negative organisms in vitro and in vivo. The compounds were only active in vivo on subcutaneous administration.
M L, Edwards, R C, Erickson
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INFRARED SPECTRA OF COMPLEXES OF 4-PYRIDONES

Canadian Journal of Chemistry, 1963
The infrared spectra of many complexes of Lewis acids with some 4-pyridones have been recorded. Large shifts to lower frequencies of about 100 cm−1 have been observed in a band near 1560 cm−1 as the Lewis acid strength increased. Much smaller shifts of about 5 to 10 cm−1 in a band near 1640 cm−1 were noted.
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Synthesis of 3-acetyl-2-amino-4-pyridone

Russian Chemical Bulletin, 1996
A method hxsynthesizing 3-acetyl-2-amino-4-pyyridone has been suggested. The synthesis involves the condensation of dimethylformamide dimethylacetal at the NH2 group of diphenylboron chelate diacetylketene aminal followed by its intramolecular cyclization under the action of NaOMe in MeOH.
V. A. Dorokhov, A. V. Komkov, A. M. Sakharo, V. S. Bogdanov   +3 more
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Interaction of water with 4-hydroxy-pyridine and 4-pyridone

Chemical Physics, 1979
Abstract The interaction energy of water with the tautomeric species 4-hydroxy-pyridine (4-h-p) and 4-pyridone (4-p) is analyzed in the SCF-LCAO-MO approximation. The interaction energies computed at many positions and orientations for a water molecule (relative to the tautomers held at fixed position) have been fitted with pair potentials of the ...
G. Corongiu, E. Clementi, M. Dagnino, L. Paoloni   +3 more
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