Results 31 to 40 of about 12,753,193 (203)
Acta Crystallographica Section E: Crystallographic Communications, 2017 In the title compound, C21H17N5O3S3·C3H7NO, the toluenesulfonamide ring and the combined ring system involving the pyridone and benzothiazole rings subtend an interplanar angle of 39.86 (4)°.
Rasha A. Azzam +3 more
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rac-2-Methyl-3,4,5,6-tetrahydro-2H-2,6-methano-1,3-benzoxazocin-4-one
Acta Crystallographica Section E, 2010 The title compound, C12H13NO2, represents a conformationally restricted 2-pyridone analogue of 1,4-dihydropyridine-type calcium antagonists and was selected for a crystal structure determination in order to explore some aspects of drug-receptor ...
Viktor Kettmann +2 more
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Avoiding pitfalls when modelling ligands in macromolecular crystallography. [PDF]
Acta Crystallogr D Struct BiolFlawed protein–ligand X‐ray structures can misdirect drug discovery based on PDB‐deposited models. This review uses publicly available PDB examples to highlight potential pitfalls, from absent ligands to incorrect chemistry, and presents a practical validation approach to improve model reliability.The determination of protein–ligand complex structures ...
Smart OS +4 more
europepmc +2 more sources
Novel Reaction Pathways for 2-Pyridone [4+4] Photoadducts
, 2016 Transannular ring closure of a pyridone−furan [4+4] photoadduct has been evaluated in a model system. A combination of nitrogen substitution and an isopropyl group gave full control of the four new stereogenic centers.
Scott McN. Sieburth (1538176) +3 more
core +3 more sources
Crystal Chemistry of Zinc Quinaldinate Complexes with Pyridine-Based Ligands
Crystals, 2018 Substitution of methanol in [Zn(quin)2(CH3OH)2] (quin− denotes an anionic form of quinoline-2-carboxylic acid, also known as quinaldinic acid) with pyridine (Py) or its substituted derivatives, 3,5-lutidine (3,5-Lut), nicotinamide (Nia), 3 ...
Barbara Modec
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Potential role of PIM1 inhibition in the treatment of SARS-CoV-2 infection
Journal of Genetic Engineering and Biotechnology, 2023 Background SARS-CoV-2 infection involves disturbing multiple molecular pathways related to immunity and cellular functions. PIM1 is a serine/threonine-protein kinase found to be involved in the pathogenesis of several viral infections. One PIM1 substrate,
Magda M. F. Ismail +8 more
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Solid-State Supramolecular Assembly of Salicylic Acid and 2-Pyridone, 3-Hydroxypyridine or 4-Pyridone [PDF]
, 2017 Mechanochemical milling of equimolar mixtures of salicylic acid with three hydroxy derivatives of pyridine provided three new phases. With 2-hydroxypyridine, which is in fact present as 2-pyridone, a discrete cocrystal supramolecular assembly is formed ...
Halasz, Ivan +13 more
core +1 more source
Synthesis, Structure, and Hydroboration Reactivity of Anionic Nickel(0) Complexes Supported by Bidentate NHC-Pyridone Ligands [PDF]
, 2022 A family of anionic, formally nickel(0) complexes supported by bidentate NHC–pyridone ligands is described. The unsymmetric chelating environment and capping [K(18-crown-6)]+ countercation allow isolation of single-component, monometallic complexes in ...
C. Rose, Kennedy +4 more
core +2 more sources
Enzymatic synthesis of vitamin B6 precursor [PDF]
Journal of the Serbian Chemical Society, 2013 3-Cyano-4-ethoxymethyl-6-methyl-2-pyridone is an important precursor in the synthesis of vitamin B6, obtained in the addition reaction between 2-cyanoacetamide and 1-ethoxy-2,4-pentanedione catalyzed by lipase from Candida rugosa ...
Prlainović Nevena Ž. +4 more
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Molecules, 2023 Two new 4-hydroxy-2-pyridone alkaloids furanpydone A and B (1 and 2), along with two known compounds N-hydroxyapiosporamide (3) and apiosporamide (4) were isolated from the endophytic fungus Arthrinium sp.
Ying Yin +7 more
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