Results 221 to 230 of about 11,648,543 (253)

Synthesis, Antimicrobial Evaluation and Molecular Docking of New Functionalized Bis(1,3,4-Thiadiazole) and Bis(Thiazole) Derivatives

Polycyclic aromatic compounds (Print), 2020
Many bis-1,3,4-thiadiazoles 7, 10a,b, 13a-c and bis-thiazoles 16a-d, 19a-d were synthesized from reaction of bis(hydrazonoyl) chloride 4 with a series of methyl carbodithioate and thiosemicarbazone derivatives.
H. Mahmoud, A. A. Abbas, Sobhi M. Gomha
semanticscholar   +1 more source

Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides

Bioorganic & Medicinal Chemistry Letters, 2017
In the present study, the synthesis of 1, 3, 4-thiadiazole-based thioglycosides were accomplished in good yields with employing a convergent synthetic route. The starting material 5-amino-1, 3, 4-thiadiazole-2-thiol and followed by a series of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thiols (4a-4j) were synthesized with different fatty acid chlorides ...
Srikanth, Vudhgiri, Dhevendar, Koude, Dileep Kumar, Veeragoni, Sunil, Misra, R B N, Prasad, Ram Chandra Reddy, Jala   +5 more
openaire   +2 more sources

Heterocyclic Amplifiers of Phleomycin. VIII. Mono- Bis-(5'-substituted 1',3',4'-thiadiazol-2'-yl)pyridines and Mono(5'-substituted 1',3',4'-thiadiazol-2'-ylmethyl)pyridines

Australian Journal of Chemistry, 1985
A series of mono- and bis -(5'-substituted 1',3',4'-thiadiazol-2'- yl )pyridines with strongly basic side chains, e.g., 3,5-bis[5'(2'-N,N- dimethylaminoethylthio )-1',3',4'-thiadiazol-2'-yl]pyridine (1), and (5?-substituted 1',3',4'-thiadiazol-2'-ylmethyl)pyridines have been prepared for evaluation as amplifiers of phleomycin.
openaire   +1 more source

Synthesis of 2,5-disubstituted-1,3,4-thiadiazole derivatives from (2S)-3-(benzyloxy)-2-[(tert-butoxycarbonyl) amino] propanoic acid and evaluation of anti-microbial activity

, 2020
The new compounds AP-1 to AP-10 were synthesized from starting material (2S)-3-(benzyloxy)-2-[(tert-butoxycarbonyl) amino]propanoic acid (1). The intermediate 2,5-disubstituted-1,3,4-thiadiazole amine (5) was prepared by coupling of (2S)-3-(Benzyloxy)-2-[
A. Pund, S. Saboo, G. Sonawane, Amol C. Dukale, B. K. Magare   +4 more
semanticscholar   +1 more source

Synthesis and biological activities of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety

Phosphorus Sulfur and Silicon and the Related Elements, 2018
A series of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety were designed, synthesized and evaluated for their antibacterial, antifungal and antiviral activities.
Xu Tang, Zhongbo Wang, Xinmin Zhong, Xiaobin Wang, Lijuan Chen, Ming He, Wei Xue   +6 more
semanticscholar   +1 more source

[Synthesis and antimycotic activity of derivatives of 1, 3, 4-thiadiazole (3,2a) pyrimidone].

Il Farmaco; edizione scientifica, 1981
As a continuation of previous research designed to obtain derivatives of 1,3,4-thiadiazole of pharmacological interest, some derivatives of 1,3,4-thiadiazole[3,2-alpha]pyrimidin-5-one and isomeric 7-one were prepared. The fungistatic activity of the products was tested in vitro against the following: Candida albicans, Candida parapsilosis, Candida ...
Russo F, Santagati M, Santagati A, BLANDINO, Giovanna   +3 more
openaire   +2 more sources

Synthesis, Characterization of New1, 3, 4-thiadiazole Derivatives with Studying their Biological Activity

Research Journal of Pharmacy and Technology, 2018
In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1,3,4-thiadiazole) as base. The main hetrocyclic compounds (1,3,4-thiadiazole, oxazole) etc. 2-amino-5-mercapto-1,3,4-thiadiazole compound [1] was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and ...
Shetha. F. Al-Zubiady, Zainab. H. Kadhim Al-Khafaji, Iman. M. Mohamed   +2 more
openaire   +1 more source

Multicomponent reaction for the synthesis of new 1,3,4-thiadiazole-thiazolidine-4-one molecular hybrids as promising antidiabetic agents through α-glucosidase and α-amylase inhibition.

Bioorganic chemistry (Print), 2021
Lalitha Gummidi, Nagaraju Kerru, O. Ebenezer, Paul Awolade, O. Sanni, M. Islam, Parvesh Singh   +6 more
semanticscholar   +1 more source

Synthesis, characterization and biological activity of some 1, 3, 4-thiadiazol derivatives.

Pakistan journal of pharmaceutical sciences, 2012
Thiadiazoles are their derivatives exhibit a wide variety of pharmacological activities such as Antibacterial and anti-inflammatory. In the present study we have synthesized derivatives some 2,5 substituted 1,3,4- thiadiazoles. The structures of these synthesized compounds were confirmed by IR, NMR, and MASS spectra data. These compounds were evaluated
Arvind Kumar, Singh, Mahfooz, Lohani, Umesh Pratap, Singh   +2 more
openaire   +1 more source

Exploring of antioxidant and antibacterial properties of novel 1, 3, 4-thiadiazole derivatives: Facile synthesis, structural elucidation and DFT approach to antioxidant characteristics

Comput. Biol. Chem., 2021
H. Muğlu, M. Akın, M. Çavuş, Hasan Yakan, Neslihan Şaki, Emre Güzel   +5 more
semanticscholar   +1 more source