Results 1 to 10 of about 10,659 (219)

Diverse Biological Activities of 1,3,4-Thiadiazole Scaffold [PDF]

Chemistry, 2022
The chemistry of 1,3,4-thiadiazole is one of the most interesting scaffolds for synthesizing new drug molecules due to their numerous pharmacological activities.
Sarvesh Paliwal, Sumitra Nain, Nain Sumitra   +2 more
exaly   +4 more sources

Recent Advances in the Synthesis and Applications of 1,2,3/1,2,5-Thiadiazole- and Benzo[c][1,2,5/1,2,3]thiadiazole-Type Compounds [PDF]

Molecules
Thiadiazole derivatives, such as 1,2,3-thiadiazole, 1,2,5-thiadiazole, benzo[c][1,2,5]thiadiazole, and benzo[d][1,2,3]thiadiazole, have garnered significant attention due to their exceptional chemical and physical properties.
Diego Quiroga, Daniel Rodríguez, Ericsson Coy-Barrera   +2 more
doaj   +2 more sources

Thiazolyl-Methylthio-1,3,4-Thiadiazole Hybrids as Halicin Analogues with Antimicrobial and Antibiofilm Activities: Chemical Development, Biological Assessment, and 2D-QSAR Study [PDF]

Antibiotics
Background/Objectives: The purpose of this study was the chemical design, synthesis, and evaluation of the antimicrobial and antibiofilm potentials of 20 novel thiazolyl-methylthio-thiadiazole hybrid compounds (6a–j and 8a–j). Methods: The compounds were
Daniel Ungureanu, Gabriel Marc, Mihaela Niculina Duma, Dan Cristian Vodnar, Gheorghe-Adrian Martău, Laurian Vlase, Adrian Pîrnău, Brîndușa Tiperciuc, Cristina Moldovan, Ioana Ionuț, Anca Stana, Ilioara Oniga, Ovidiu Oniga   +12 more
doaj   +2 more sources

Synthetic Transformations and Medicinal Significance of 1,2,3-Thiadiazoles Derivatives: An Update

Applied Sciences, 2021
The 1,2,3-thiadiazole moiety occupies a significant and prominent position among privileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics due to its broad spectrum of biological activities.
Ali Irfan, Sami Ullah, Ayesha Anum, Nazish Jabeen, Ameer Fawad Zahoor, Hafza Kanwal, Katarzyna Kotwica-Mojzych, Mariusz Mojzych   +7 more
doaj   +1 more source

Synthesis, Biological and Docking Studies of Thiadiazole Amide Derivatives Containing Anthranilic Acid [PDF]

Journal of Sciences, Islamic Republic of Iran, 2023
Cancer has been become threatening the health and life of humans. Therefore, attempt to discovery more effective anticancer agents continue. Thiadiazole derivatives have been shown remarkable effects among chemotherapeutic agents.
farshid hassanzadeh, elham jafari, mahshid farzan, Hojjat Sadeghi-aliabadi   +3 more
doaj   +1 more source

Thiadiazoles: the appropriate pharmacological scaffolds with leishmanicidal and antimalarial activities: a review [PDF]

Iranian Journal of Basic Medical Sciences, 2017
Leishmaniasis and malaria are serious public health problems in tropical and sub-tropical regions worldwide. Development of drug-resistant strains has disrupted efforts to control the spread of these diseases in the world.
Azar Tahghighi, Fateme Babalouei
doaj   +1 more source

2-Methyl-6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone Synthon for Some New Annelated 1,2,3-Selena/Thiadiazoles and 2H-Diazaphospholes with Anticipated Biological Activity and Quantum Chemical Calculations

Molecules, 2023
A convenient and efficient synthetic protocol for the new selenadiazole. Thiadiazole and diazaphosphole derivatives incorporating a pyridazine moiety originating from 4-(4-aminophenyl)-4-oxobutanoic acid (1) were described.
I. E. El-Shamy, E. Hleli, M. A. El-Hashash, I. Kelnar, A. M. Abdel-Mohsen   +4 more
doaj   +1 more source

Synthesis and Bioactivities of Novel Galactoside Derivatives Containing 1,3,4-Thiadiazole Moiety

Frontiers in Chemistry, 2022
A series of novel galactoside derivatives containing 1,3,4-thiadiazole moiety were synthesized, and the structure of them was verified by spectroscopy of NMR and HRMS, and antifungal and antibacterial activities of them were screened.
Yafei Shu, Meihang Chen, Daowang Lu, Zengyan Zhou, Jianhong Yu, Xiaoling Hu, Jiaqin Yang, Aiqin Li, Jianglong Liu, Hairong Luo   +9 more
doaj   +1 more source

Construction of Thiadiazole‐Linked Covalent Organic Frameworks via Facile Linkage Conversion with Superior Photocatalytic Properties

Advanced Science, 2023
The establishment of facile synthetic routes to engineer covalent organic frameworks (COFs) with fully conjugated structure and excellent stability is highly desired for practical applications in optoelectronics and photocatalysis.
Shuailong Yang, Ziao Chen, Lei Zou, Rong Cao   +3 more
doaj   +1 more source

Synthesis of some Schiff's bases derivatives from aminoazo compounds

مجلة بغداد للعلوم, 2007
Reaction of,2- [( 4- amio phenyl ) diazenyl] 1,3,4- thiadiazole -5- thiol (S1) with p- chlorobenzeldehyde,3,4 – dimethoxy benzaldehyde and pyrrol-2- carbonxaldehyde gave -5- [{4-(4-chlorobenzylidene amino) phenyl} diezenyl]-1,3,4- thiadiazole-2- thiol ...
Baghdad Science Journal
doaj   +1 more source