Results 21 to 30 of about 11,765 (225)

Synthesis of Oxadiazoles, Thiadiazoles and Triazoles Derived from Benzo[b]thiophene

Molecules, 2005
In this work 3-chloro-2-chlorocarbonylbenzo[b]thiophene (1) was prepared from cinnamic acid and then converted into the acid hydrazide 2. The azomethines 3a-e were prepared from the corresponding aryl aldehydes and the acid hydrazide 2.
N. Rezki, M. Aouad, R. Al-Bayati, A. Sharba   +3 more
doaj   +1 more source

Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides

Frontiers in Chemistry, 2021
A series of novel 1,3,4-thiadiazole derivatives of glucosides were synthesized by the starting materials d-glucose and 5-amino-1,3,4-thiadiazole-2-thiol in good yields with employing a convergent synthetic route.
Meihang Chen, Xun Zhang, Daowang Lu, Hairong Luo, Zengyan Zhou, Xufeng Qin, Wenneng Wu, Guoping Zhang   +7 more
doaj   +1 more source

Discovery of Matrinic Thiadiazole Derivatives as a Novel Family of Anti-Liver Fibrosis Agents via Repression of the TGFβ/Smad Pathway

Molecules, 2018
A series of novel matrinic thiadiazole derivatives were designed, synthesized and evaluated for their inhibitory effect on COL1A1 promotor. The SAR indicated that: (i) the introduction of a thiadiazole on the 11-side chain was beneficial for activity ...
Tianyu Niu, Weixiao Niu, Yunyang Bao, Ting Liu, Danqing Song, Yinghong Li, Hongwei He   +6 more
doaj   +1 more source

Ionic Liquid Catalyzed One-Pot Synthesis of 5-(4-Substituted-Phenyl)-1,3,4-Thiadiazole-2-Amines

, 2022
A highly efficient ionic liquid catalyzed protocol has been investigated for the synthesis of 5-(4-substituted-phenyl)-1,3,4-thiadiazole-2-amine derivatives from the cyclocondensation of diversely substituted aromatic carboxylic acid and ...
Dinesh Lingampalle (14277729), Nayana Pahade (14277720), Devendra Wagare (14277723), D. W. Shinde (14277726)   +3 more
core   +1 more source

Photochemical Ring Editing: Access to Privileged 1,2,5-Thiadiazole Scaffolds via Efficient Carbon Excision from Thiadiazines Under Ambient, Aerobic Conditions [PDF]

, 2022
Thiadiazoles are a privileged motif in medicinal chemistry, however selective mono-oxidation of the endocyclic sulfur, without over oxidation, is challenging.
Panayiotis A., Koutentis, Brendan, Gallagher, Georgina M., Rosair, Andreas S., Kalogirou, Christopher G., Thomson, Stuart A., Macgregor, Lia, Sotorríos, Gareth O., Lloyd, Kenneth G., McKendrick, Filipe, Vilela, Emmanouil, Broumidis, Janet E., Lovett, Martin J., Paterson   +12 more
core   +2 more sources

Synthesis and antiproliferative evaluation of novel 1,3,4-thiadiazole-S-alkyl derivatives based on quinazolinone

, 2023
Thirty-five novel 1,3,4-thiadiazole-S-alkyl derivatives based on quinazolinone have been designed and synthesized. The structures of the target compounds 5a − 5p and 6a − 6s were confirmed by their IR, 1H NMR, 13C NMR, HR-ESI-MS spectroscopic data.
Yanle Men (12510268), Zijian Li (339839), Xuguang Liu (1397908), Hongying Wang (327907), Baoquan Chen (2648587), Yuming Liu (610387)   +5 more
core   +1 more source

Extending El Sayed's Rule by 1(n,π*)–3(n,π*) Rotation via Intramolecular Secondary Interaction Enables Room‐Temperature Circularly Polarized Phosphorescence in Solution

Angewandte Chemie, EarlyView.
Weak but skilled: Our results highlight the crucial role of intramolecular secondary interactions to induce an efficient ISC between formally identical 1(n,π*) and 3(n,π*) states in chiral thionated phthalimide derivatives. This unprecedented type of inter‐system crossing (ISC) extends the usual thinking of the El‐Sayed principle and enables the ...
Oscar Charpentier, Marie Guesdon, Catherine Demangeat, Maher Hojorat, Joseph Young, Emrys W. Evans, Vincent Dorcet, Nicolas Galland, Denis Jacquemin, Ludovic Favereau   +9 more
wiley   +2 more sources

Synthesis of Some Novel Thiadiazole Derivative Compounds and Screening Their Antidepressant-Like Activities

Molecules, 2018
Novel thiadiazole derivatives were synthesized through the reaction of acetylated 2-aminothiadiazole and piperazine derivatives. The chemical structures of the compounds were clarified by Infrared Spectroscopy (IR), 1H Nuclear Magnetic Resonance ...
Nafiz Öncü Can, Özgür Devrim Can, Derya Osmaniye, Ümide Demir Özkay   +3 more
doaj   +1 more source

Antiparasitic Behavior of Trifluoromethylated Pyrazole 2-Amino-1,3,4-thiadiazole Hybrids and Their Analogues: Synthesis and Structure-Activity Relationship

Frontiers in Pharmacology, 2020
A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1,3,4-thiadiazole hybrids were synthesized and evaluated in vitro against the promastigote form of ...
Jeniffer do Nascimento Ascencio Camargo, Karlos Eduardo Pianoski, Mariellen Guilherme dos Santos, Danielle Lazarin-Bidóia, Hélito Volpato, Sidnei Moura, Celso Vataru Nakamura, Fernanda Andreia Rosa   +7 more
doaj   +1 more source

Synthesis of Some New Benzimidazole Derivatives Containing Chlorine and Investigation of Their Antioxidant and Anti-urease Activities

Journal of the Turkish Chemical Society, Section A: Chemistry, 2018
In this work, the synthesis of 2-substituted benzimidazole compound containing chlorine (1) was carried out and then converted to the ester (2) and hydrazide (3) derivatives respectively. In the next steps, the hydrazide compound (3) was reacted with the
Nesrin Karaali
doaj   +1 more source