Results 51 to 60 of about 1,938,956 (246)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effect of Radical‐Mediated Cross‐Linking on Partially Fluorinated Aromatic Anion Exchange Membranes and their Applications in Alkaline Water Electrolysis Cells

Advanced Energy & Sustainability Research
To investigate the effect of cross‐linking on partially fluorinated anion exchange membranes tethered with trimethylpropyl side chains (QPAF‐C3), styrene‐based cross‐linker is introduced into the precursor copolymers and then cross‐linked via free ...
Ahmed Mohamed Ahmed Mahmoud, Kenji Miyatake, Fanghua Liu, Vikrant Yadav, Lin Guo, Chun Yik Wong, Toshio Iwataki, Katsuyoshi Kakinuma, Makoto Uchida   +8 more
doaj   +1 more source

Interaction of nanosecond laser pulse with tetramethyl silane (Si(CH3)4) clusters: Generation of multiply charged silicon and carbon ions

AIP Advances, 2011
Present work reports significantly high levels of ionization, eventually leading to Coulomb explosion of Tetramethyl silane (TMS) clusters, on interaction with laser pulses of intensity ∼109 W/cm2.
Purav M. Badani, Soumitra Das, Venkateswara Rao Mundlapati, Pramod Sharma, Rajesh K. Vatsa   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Determination of Free Levels of Cinitipride in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry

E-Journal of Chemistry, 2008
A rapid, sensitive and specific method to quantify cinitapride in human plasma using risperidone as the internal standard is described. Sample preparation involved simple solid phase extraction procedure.
Shikha M. N. Roy, Santos H. M. Yetal, Sangita V. Chavan, Vara D. R. Pradhan, Santosh S. Joshi   +4 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Fifty Years of Development Economics: From Planning to Liberalization Essay in Honour of Prof. P.R.Brahmanande

Malaysian Management Journal, 2000
Fifty Years of Development Economics, Essays in Hon­our of Professor P.R. Brahmananda, Editors A. Vasedevan, D.M. Nachane, A.V. Karnik, Foreword Lord Meghnad Desai, Himalaya Publishing House, Mumbai 400 004, First Edition - 1999.
Vesudevan A., Nachare D.M, Karnik A.V
doaj  

Electrochemical studies on the corrosion inhibition efficiency of 3,4-diphenyl-2,5-thiophenedicarboxylic acid for mild steel in 1 M HCl

Next Materials
The present work reports, for the first time, the corrosion inhibition performance of 3,4-diphenyl-2,5-thiophenedicarboxylic acid, a newly designed thiophene-based dicarboxylic acid, on mild steel in 1 M HCl solution.
Sai P. Katke, Sanket S. Mohite, Jaydeep S. Yadav, Rohit D. Chaurasiya   +3 more
doaj   +1 more source

Mass transport induced asymmetry in charge/discharge behavior of liquid metal batteries

Electrochemistry Communications, 2019
Mass and charge transport in liquid metal batteries are closely intertwined because of the fully liquid interior of the cells. We found that charging and discharging cycles may show pronounced asymmetries.
Paolo Personnettaz, Steffen Landgraf, Michael Nimtz, Norbert Weber, Tom Weier   +4 more
doaj   +1 more source