Results 111 to 120 of about 1,029,481 (281)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
, 2019 Today, 3D has become a new and powerful form of expression, communication and knowledge transmission. With this powerful tool, the teacher will be able to articulate an attractive narrative and visual discourse.
NASA +2 more
core +1 more source
Advances in Orthopedics, 2013 Purpose. Comparison of monoaxial and polyaxial screws with the use of subcutaneous anterior pelvic fixation. Methods. Four different groups each having 5 constructs were tested in distraction within the elastic range.
Rahul Vaidya +3 more
doaj +1 more source
Introduction to 4D Motion Modeling and 4D Radiotherapy
, 2013 The fusion of the fast growing fields of imaging science, imaging hardware, and computational modeling, together with a broad interest in learning more about respiratory anatomy and physiology, has led to major advances in the scientific understanding and clinical applications of 4D motion modeling and radiotherapy. The advent of respiratory correlated,
Paul Keall, Tokihiro Yamamoto, Yelin Suh
openaire +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Castillo de Santa Magdalena de Pulpis
, 2019 Proyecto geomático realizado por AD&D 4D para la Diputación de Castellónhttps://www.castellonarqueologico.es/yacimientos/el-baix-maestrat/castillo-santa-magdalena-de-pulpis/https://www.castellonarqueologico.es/va/yacimientos/el-baix-maestrat/castillo ...
Muñoz, Robert, AD&D 4D
core
Microstructure and mechanical properties of co-sputtered Al-SiC composites
Materials & Design, 2019 Nanolaminates have gained much attention due to exceptional mechanical, optical, electrical and biological properties. In this work, we explore the microstructure and mechanical properties of Al-SiC co-sputtered monolayers having different compositions ...
Somya Singh +5 more
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
4D Cardiff Conversation Database (4D CCDb): A 4D database of natural,dyadic conversations [PDF]
The 4D Cardiff Conversation Database (4D CCDb) is the first\ud 4D (3D Video) audio-visual database containing natural conversations\ud between pairs of people. This publicly available\ud database contains 17 conversations which have been fully annotated\ud for speaker and listener activity: conversational facial\ud expressions, head motion, and verbal ...
Jason Vandeventer +3 more
openaire +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source