Results 31 to 40 of about 257,066 (245)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Dependence of plasminogen activator inhibitor-1 level on -675 4G/5G polymorphism in PAI-1 gene in patients with traumatic brain injury

Ukrainian Neurosurgical Journal, 2014
The purpose. To study relationship between plasminogen activator inhibitor-1 (PAI-1) level in plasma and -675 4G/5G polymorphism in the PAI-1 gene in patients with traumatic brain injury (TBI) in dynamics of treatment.Materials and methods ...
Oleksandr Potapov Jr, Oleksii Kmyta
doaj   +1 more source

Clinical impact of the PAI-1 4G/5G polymorphism in Chinese patients with venous thromboembolism

Thrombosis Journal, 2022
Background Venous thromboembolism (VTE) is a life-threatening cardiovascular syndrome that characterized by the imbalance of hemostasis and thrombosis and the formation of thrombi in the blood vessels.
Ziran Wang, Lingjun Kong, Guoju Luo, Han Zhang, Fengchun Sun, Wenjuan Liang, Wei Wu, Zijian Guo, Rui Zhang, Yaling Dou   +9 more
doaj   +1 more source

The 4G/4G Genotype of the PAI-1 (Serpine-1) 4G/5G Polymorphism Is Associated With Decreased Lung Allograft Utilization [PDF]

American Journal of Transplantation, 2012
Widespread thrombi are found among donor lungs rejected for transplantation. The 4G/5G polymorphism in the plasminogen activator inhibitor (PAI-1) gene impacts transcription and the 4G allele is associated with increased PAI-1 levels. We hypothesized that the 4G/4G genotype would be associated with decreased lung graft utilization, potentially because ...
A, Sapru, J G, Zaroff, L, Pawlikowska, K D, Liu, K K, Khush, L A, Baxter-Lowe, V, Hayden, R L, Menza, M, Convery, V, Lo, A, Poon, H, Kim, W L, Young, J, Kukreja, M A, Matthay   +14 more
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

4G in the EU

, 2022
The DESI Index calculates the value of the percentage of the national territory with 4G coverage. The data refer to the period 2016-2021. The DESI Index excludes the UK from the monitored countries.
openaire   +3 more sources

Plasminogen activator inhibitor-1 4G/5G polymorphism and retinopathy risk in type 2 diabetes: a meta-analysis

BMC Medicine, 2013
Background Mounting evidence has suggested that plasminogen activator inhibitor-1 (PAI-1) is a candidate for increased risk of diabetic retinopathy. Studies have reported that insertion/deletion polymorphism in the PAI-1 gene may influence the risk of ...
Zhang Tengyue, Pang Chong, Li Ningdong, Zhou Elaine, Zhao Kanxing   +4 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Intelligent Computational Model for Energy Efficiency and AI Automation of Network Devices in 5G Communication Environment

Tsinghua Science and Technology
Currently, the 4G network service has caused massive digital growth in high use. Video calling has become the go-to Internet application for many people, downloading even huge files in minutes.
Ashish Bagwari, Jaganathan Logeshwaran, M. Raja, P. Devisivasankari, Jyotshana Bagwari, Vikas Rathi, Asma Mohammed Elbashir Saad   +6 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source