Results 1 to 10 of about 59,929 (255)
Plasminogen Activator Inhibitor 1, Cell Senescence, and Aging-Related Diseases. [PDF]
CellsCellular senescence, including replicative senescence (RS) and stress-induced premature senescence (SIPS), is a state of the permanent arrest of cell growth, which can occur in proliferative cells and post-mitotic cells.
Liu RM, Nakamya MF.
europepmc +2 more sources
Functional Stability of Plasminogen Activator Inhibitor-1 [PDF]
The Scientific World Journal, 2014 Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of plasminogen activators, such as tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), and a major regulator of the fibrinolytic system.
Songul Yasar Yildiz +3 more
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Adaption of the plasmin generation assay to enhance sensitivity to plasminogen activator inhibitor-1 and establishment of sex-specific reference values in human plasma. [PDF]
Res Pract Thromb HaemostBackground: Pharmacologic modifiers of fibrinolysis are used to modulate bleeding and thrombosis. Characterization of a sensitive plasmin generation (PG) assay to identify abnormal fibrinolytic states and monitor antifibrinolytic medication may improve ...
De Simone I +9 more
europepmc +2 more sources
Does plasminogen activator inhibitor-1 drive lymphangiogenesis? [PDF]
PLoS ONE, 2010 The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least ...
Françoise Bruyère +11 more
doaj +6 more sources
PLoS ONE, 2017 Due to controversial evidence in the literature pertaining to the activity of plasminogen activator inhibitor-1 in platelets, we examined the effects of residual platelets present in plasma (a potential pre-analytical variable) on various plasminogen ...
Marlien Pieters +3 more
doaj +3 more sources
Plasminogen activator inhibitor-1 in the evolution of stroke [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2004 Fibrinolytic activity in the acute stroke was examined by monitoring the level of plasminogen activator inhibitor-1 (PAI-1), as one of the indicators of fibrinolytic activity.
Jovanović Zagorka B. +8 more
doaj +4 more sources
Plasminogen Activator Inhibitor-1 in the Pathogenesis of Asthma
Experimental Biology and Medicine, 2004 Plasminogen activator inhibitor (PAI)-1 is the main inhibitor of the fibrinolytic system and is known to play an essential role in tissue remodeling. Recent evidence indicates that chronic asthma may lead to tissue remodeling such as subepithelial fibrosis and extracellular matrix (ECM) deposition in the airways. However, the role of PAI-1 in asthma is
Seong H Cho, Chad K Oh
exaly +3 more sources
Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer
Cell Reports, 2018 Summary: Plasminogen activator inhibitor-1 (PAI-1) has a pro-tumorigenic function via its pro-angiogenic and anti-apoptotic activities. Here, we demonstrate that PAI-1 promotes the recruitment and M2 polarization of monocytes/macrophages through ...
Vasu Punj +2 more
exaly +3 more sources
Involvement of plasminogen activator inhibitor-1 and its related molecules in atrial fibrosis in patients with atrial fibrillation [PDF]
PeerJ, 2021 Atrial fibrillation is the most common form of cardiac arrhythmia. Atrial fibrosis is a significant feature of atrial fibrillation though its mechanism is not well understood.
Qiaoqiao Li +11 more
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Clinical and Applied Thrombosis/Hemostasis, 2023 Background Vitamin D deficiency has recently been suggested as an independent risk factor for thrombosis. Notably, vitamin D deficiency is common in pregnant populations, whom already have an increased thrombotic risk.
Matilde Kanstrup Andersen BA +6 more
doaj +1 more source