Results 1 to 10 of about 60,509 (116)

Plasminogen Activator Inhibitor 1, Cell Senescence, and Aging-Related Diseases [PDF]

Cells
Cellular senescence, including replicative senescence (RS) and stress-induced premature senescence (SIPS), is a state of the permanent arrest of cell growth, which can occur in proliferative cells and post-mitotic cells.
Rui-Ming Liu, Mary F. Nakamya
doaj   +2 more sources

Adaption of the plasmin generation assay to enhance sensitivity to plasminogen activator inhibitor-1 and establishment of sex-specific reference values in human plasma [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Pharmacologic modifiers of fibrinolysis are used to modulate bleeding and thrombosis. Characterization of a sensitive plasmin generation (PG) assay to identify abnormal fibrinolytic states and monitor antifibrinolytic medication may improve ...
Ilaria De Simone, Kieran Pocknell, Samia Tufaha, Joke Konings, Mark Roest, Alisa S. Wolberg, Claire S. Whyte, Nicola J. Mutch, Bas de Laat, Dana Huskens   +9 more
doaj   +2 more sources

Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer

Cell Reports, 2018
Summary: Plasminogen activator inhibitor-1 (PAI-1) has a pro-tumorigenic function via its pro-angiogenic and anti-apoptotic activities. Here, we demonstrate that PAI-1 promotes the recruitment and M2 polarization of monocytes/macrophages through ...
Marta Helena Kubala, Vasu Punj, Veronica Rae Placencio-Hickok, Hua Fang, G. Esteban Fernandez, Richard Sposto, Yves Albert DeClerck   +6 more
doaj   +3 more sources

Involvement of plasminogen activator inhibitor-1 and its related molecules in atrial fibrosis in patients with atrial fibrillation [PDF]

PeerJ, 2021
Atrial fibrillation is the most common form of cardiac arrhythmia. Atrial fibrosis is a significant feature of atrial fibrillation though its mechanism is not well understood.
Qiaoqiao Li, Yingyu Lai, Xiaoyan Gao, Xin Li, Chun-Yu Deng, Huiming Guo, Junfei Zhao, Hui Yang, Yuwen Xu, Shulin Wu, Yumei Xue, Fang Rao   +11 more
doaj   +2 more sources

Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy

Clinical and Applied Thrombosis/Hemostasis, 2023
Background Vitamin D deficiency has recently been suggested as an independent risk factor for thrombosis. Notably, vitamin D deficiency is common in pregnant populations, whom already have an increased thrombotic risk.
Matilde Kanstrup Andersen BA, Isabella Hangaard Rüdiger MD, Anna Louise Vestergaard MD, PhD, Yaseelan Palarasah MS, PhD, Pinar Bor MD, PhD, Agnete Larsen MD, PhD, Mustafa Vakur Bor MD, PhD   +6 more
doaj   +1 more source

Thrombo-inflammatory biomarkers to predict sepsis outcome

International Journal of Immunopathology and Pharmacology, 2021
Background: Sepsis has been redefined recently as life-threatening organ dysfunction caused by dysregulated host responses to infection and septic shock. Soluble urokinase plasminogen activator receptor (SuPAR) and plasminogen activator inhibitor-1(PAI-1)
Alaa Efat, Sabry Abdallah Shoeib, Ayman F Arafa, Ashraf Abdelraof Dawod, Mohamad A Abd ElHafez, Essam A Abd ElMohsen, Hany F Eladly, Reda A Ibrahim, Aly Elkholy   +8 more
doaj   +1 more source

Does plasminogen activator inhibitor-1 drive lymphangiogenesis? [PDF]

PLoS ONE, 2010
The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least ...
Françoise Bruyère, Laurence Melen-Lamalle, Silvia Blacher, Benoît Detry, Anne Masset, Julie Lecomte, Vincent Lambert, Catherine Maillard, Gunilla Høyer-Hansen, Leif R Lund, Jean-Michel Foidart, Agnès Noël   +11 more
doaj   +1 more source

Histone deacetylase inhibitor treatment increases coronary t-PA release in a porcine ischemia model. [PDF]

PLoS ONE, 2014
BACKGROUND: The expression of the tissue plasminogen activator gene can be affected by histone deacetylation inhibition and thus appears to be under epigenetic control.
Kristina Svennerholm, Niklas Bergh, Pia Larsson, Sverker Jern, Göran Johansson, Björn Biber, Michael Haney   +6 more
doaj   +1 more source

Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients

Scientific Reports, 2021
Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients.
Yu Zuo, Mark Warnock, Alyssa Harbaugh, Srilakshmi Yalavarthi, Kelsey Gockman, Melanie Zuo, Jacqueline A. Madison, Jason S. Knight, Yogendra Kanthi, Daniel A. Lawrence   +9 more
doaj   +1 more source

Association of fibrinogen and plasminogen activator inhibitor-1

Pakistan Journal of Pharmaceutical Sciences, 2022
As the state of hyperfibrinogenemia in diabetes patients occurs due to hyperglycemia which also activates the coagulative cascade ultimately stimulating hepatic fibrinogen synthesis and thus increases clotting factors and PAI-1 levels in the blood ...
with diabetes mellitus Iffat Ara Aziz, Asher Fawwad, Iftikhar Ahmed Siddiqui, Kahkashan Perveen, Ruqaya Nangrejo, Nazish Waris, Abdul Basit   +6 more
doaj   +1 more source