Results 31 to 40 of about 112,049 (293)

Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]

, 2018
Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean, Halliday, Christopher, Jahagirdar, Ravi, Johansson, Jan O, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina, Robson, Richard, Stotz, Stephanie C, Sweeney, Michael, Tsujikawa, Laura M, Wasiak, Sylwia, Wong, Norman C   +11 more
core   +2 more sources

Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis.

PLoS ONE, 2019
PurposeDeep infiltrating endometriosis (DIE) is defined as an endometriotic lesion penetrating to a depth of >5 mm and is associated with pelvic pain, but the underlying mechanisms are unclear.
Fahad T Alotaibi, Bo Peng, Christian Klausen, Anna F Lee, Amr O Abdelkareem, Natasha L Orr, Heather Noga, Mohamed A Bedaiwy, Paul J Yong   +8 more
doaj   +1 more source

Plasminogen activator inhibitor-1 in the evolution of stroke [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2004
Fibrinolytic activity in the acute stroke was examined by monitoring the level of plasminogen activator inhibitor-1 (PAI-1), as one of the indicators of fibrinolytic activity.
Jovanović Zagorka B., Ilić Mirka, Zidverc-Trajković Jasna, Pavlović Aleksandra M., Mijajlović Milija, Šternić-Čovičković Nadežda, Stanković Sanja, Beslać-Bumbaširević Ljiljana G., Kostić Vladimir S.   +8 more
doaj   +1 more source

A Perspective of Coagulation Dysfunction in Multiple Sclerosis and in Experimental Allergic Encephalomyelitis [PDF]

, 2018
A key role of both coagulation and vascular thrombosis has been reported since the first descriptions of multiple sclerosis (MS). Subsequently, the observation of a close concordance between perivascular fibrin(ogen) deposition and the occurrence of ...
Adams, Adams, Akassoglou, Akassoglou, Akenami, Akenami, Albright, Alizadeh, Alonso, Amor, Antoniak, Beggs, Bidot, Bitsch, Boesen, Brkic, Bronstein, Brunetti, Castellino, Cesarman-Maus, Chapman, Chelmicka-Szorc, Claudio, Compston, Coughlin, Cuzner, Danø, Davalos, Davalos, Davidson, Davie, De Luca, Dekaban, Deschepper, Donovan, East, Ed Rainger, Engelmann, Esmon, Esmon, Fan, Fan, Farber, Feldman, Ferguson, Festoff, Field, Fiorini, Flick, Fog, Friedman, Garcia-Monco, García, Garg, Genc, Gloor, Griffin, Griffin, Guenther, Gveric, Göbel, Göbel, Göbel, Hafler, Han, Horstman, Huszak, Inaba, Inoue, Iong, Jacob, Jones, Kalaria, Kirichuk, Kirk, Kirk, Knauer, Koudriavtseva, Koudriavtseva, Koudriavtseva, Koudriavtseva, Kreutzberg, Kuhlmann, Kwon, Lane, Langer, Lassmann, Lassmann, Lassmann, Lesny, Liddelow, Lider, Lin, Lin, Lock, Lu, Mahmood, Mandoj, Marik, Mechelli, Miranda, Moll, Murray, Park, Parsons, Paterson, Perez, Persson, Persson, Petersen, Phillips, Pike, Plantone, Plumb, Putnam, Putnam, Rand, Reese, Reinhard, Roizin, Ryu, Ryu, Saberi, Savitky, Seeds, Seeds, Sheremata, Simón, Smith, Sobel, Soon, Sotnikov, Spadaro, Starossom, Starossom, Stavrou, Stolz, Teesalu, Tennent, Ugarova, Uzawa, van der Poll, Varga, Verrall, Wachowicz, Wakefield, Weisel, Whitlock, Wittinghofer, Wolter, Wright, Xue, Yadav, Yamaji, Yates, Yuksel, Zhang, Ziliotto, Zivadinov   +158 more
core   +1 more source

Impact of PAI-1 4G/5G and C > G polymorphisms in acute ST elevation myocardial infarction and stable angina patients: A single center Egyptian study

Egyptian Journal of Medical Human Genetics, 2018
Background: Many genetic factors, including polymorphisms in the genes regulating blood coagulation and fibrinolysis have been proposed as risk factors for coronary artery disease (CAD).
Hanan Al-Wakeel, Nadia Sewelam, Mohamed Khaled, Akram Abdelbary   +3 more
doaj   +1 more source

Plasminogen Activator Inhibitor-1 [PDF]

Circulation, 2013
Hypertension is the most common reversible risk factor for stroke, myocardial infarction, and heart failure, affecting >60 million individuals in the United State alone and 1 billion globally.1 According to the World Health Organization, hypertension is now the leading cause of preventable death worldwide.2 Importantly, the prevalence and complications
Daniel I, Simon, Norman M, Simon
openaire   +2 more sources

The uPA System Differentially Alters Fibroblast Fate and Profibrotic Ability in Skin Fibrosis

Frontiers in Immunology, 2022
Skin fibrosis is a common pathological feature of various diseases, and few treatment strategies are available because of the molecular pathogenesis is poorly understood.
Ming-Li Zou, Ming-Li Zou, Ying-Ying Teng, Zhong-hua Chen, Si-Yu Liu, Yuan Jia, Kai-Wen Zhang, Jun-Jie Wu, Zheng-Dong Yuan, Xiao-Yu Tang, Shun Yu, Jun-Xing Ye, Xia Li, Xiao-Jin Zhou, Feng-Lai Yuan, Feng-Lai Yuan   +15 more
doaj   +1 more source

Plasminogen activator inhibitor-1: a review Plasminogen-Aktivator-Inhibitor-1: eine Übersicht [PDF]

LaboratoriumsMedizin, 2005
Abstract Plasminogen activator inhibitor-1 (PAI-1) is the most potent inhibitor of both tissue type (t-PA) and urokinase type plasminogen activator (u-PA) and thus regulates fibrinolysis as well as proteolysis, cell migration, and tumor cell invasiveness.
Markus Pihusch, Verena Pihusch, Ernst Holler   +2 more
openaire   +1 more source

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans [PDF]

, 2017
The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is
Beckham, Simone, Cops, Elisa J., Daglas, Maria, Freeman, Roxann, Galle, Adam, Lawrence, Daniel A., Madani, Rime, McLean, Catriona, Medcalf, Robert L., Morganti-Kossmann, Cristina, Rosenfeld, Jeffrey V., Sales, Eunice, Samson, Andre L., Sashindranath, Maithili, Su, Enming J., Vassalli, Jean-Dominique   +15 more
core  

Cytotoxicity of the urokinase-plasminogen activator inhibitor carbamimidothioic acid (4-boronophenyl) methyl ester hydrobromide (BC-11) on triple-negative MDA-MB231 breast cancer cells [PDF]

, 2015
: BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal ...
Baltus, Christine B, Chuckowree, Irina S, Librizzi, Mariangela, Longo, Alessandra, Luparello, Claudio, Spencer, John   +5 more
core   +2 more sources