Results 1 to 10 of about 69,700 (263)

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition [PDF]

Frontiers in Cardiovascular Medicine, 2020
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs).
Machteld Sillen, Paul Declerck, Declerck Paul J   +2 more
exaly   +5 more sources

Reversing PAI-1 deficiency in blood using mRNA lipid nanoparticles [PDF]

Molecular Therapy: Methods & Clinical Development
Plasminogen activator inhibitor-1 (PAI-1) deficiency is a rare disorder that causes moderate to severe bleeding and cardiac fibrosis, caused by mutation in the SERPINE-1 gene and no detectable circulating PAI-1 protein.
Francesca Ferraresso, Chad W. Skaer, Katherine Badior, Serena M. Pulente, Manoj Paul, Laura Ketelboeter, Taylor H.S. Chen, Pieter R. Cullis, Sweta Gupta, Amy Shapiro, Erin E. Mulvihill, Christian J. Kastrup   +11 more
doaj   +2 more sources

PAI-1 and the Metabolic Syndrome [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2006
The link between plasminogen activator inhibitor (PAI)-1 and the metabolic syndrome with obesity was established many years ago. Increased PAI-1 level can be now considered a true component of the syndrome. The metabolic syndrome is associated with an increased risk of developing cardiovascular disease, and PAI-1 overexpression may participate in this ...
Marie-Christine Alessi, Irène Juhan-Vague   +1 more
exaly   +3 more sources

Influence of high intensity interval training on adipose tissue PAI-2 and MMP-2 mRNAs expression in rat with high-fat diet-induced metabolic syndrome [PDF]

Journal of Exercise & Organ Cross Talk, 2022
The aim of this study was to investigate the influence of high intensity interval training on adipose tissue PAI-2 and MMP-2 mRNAs expression in rat with high-fat diet-induced metabolic syndrome.
Mojgan Banihashemi, Ensiyeh Yazdkhasti, Maryam Mahmoudi Haghshenas, Fatemeh Rostamkhani   +3 more
doaj   +1 more source

Upaya Meningkatkan Hasil Belajar Siswa Kelas VIII A SMP Negeri 1 Buntulia Pada Mata Pelajaran Pendidikan Agama Islam Melalui Penerapan Model Pembelajaran Kooperatif tipe Think Talk Write

Aksara, 2021
Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) dengan mencoba menerapan salah satu model pembelajaran untuk mengaktifkansiswa dan mengefektifkan proses pembelajaran yaitu pembelajaran kooperatif tipe Think Talk Write.
Warni Diange
doaj   +1 more source

PAI-1 and kidney fibrosis [PDF]

Frontiers in Bioscience, 2009
Substantial evidence demonstrates a link of increased plasminogen activator inhibitor-1 (PAI-1) and glomerulosclerosis and kidney fibrosis, providing a novel therapeutic option for prevention and treatment of chronic kidney diseases. Several mechanisms contributing to increased PAI-1 will be addressed, including classic key profibrotic factors such as ...
Li-Jun, Ma, Agnes B, Fogo
openaire   +2 more sources

PAI‐1 in tissue fibrosis [PDF]

Journal of Cellular Physiology, 2011
AbstractFibrosis is defined as a fibroproliferative or abnormal fibroblast activation‐related disease. Deregulation of wound healing leads to hyperactivation of fibroblasts and excessive accumulation of extracellular matrix (ECM) proteins in the wound area, the pathological manifestation of fibrosis.
Asish K, Ghosh, Douglas E, Vaughan
openaire   +2 more sources

Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. [PDF]

PLoS ONE, 2015
Sepsis-induced acute kidney injury (AKI) contributes to the high mortality and morbidity in patients. Although the pathogenesis of AKI during sepsis is poorly understood, it is well accepted that plasminogen activator inhibitor-1 (PAI-1) and vitronectin (
Kamlesh K Gupta, Deborah L Donahue, Mayra J Sandoval-Cooper, Francis J Castellino, Victoria A Ploplis   +4 more
doaj   +1 more source

Plasminogen Activating Inhibitor-1 Might Predict the Efficacy of Anti-PD1 Antibody in Advanced Melanoma Patients

Frontiers in Oncology, 2021
Plasminogen activating inhibitor-1 (PAI-1) plays crucial roles in the development of various cancers, including melanomas. Indeed, various pro-tumorigenic functions of PAI-1 in cancer progression and metastasis have been widely reported.
Kentaro Ohuchi, Yumi Kambayashi, Takanori Hidaka, Taku Fujimura   +3 more
doaj   +1 more source

Plasminogen activator inhibitor-1 is involved in impaired bone repair associated with diabetes in female mice. [PDF]

PLoS ONE, 2014
Previous studies suggest that fracture healing is impaired in diabetes; however, the underlying mechanism remains unclear. Here, we investigated the roles of plasminogen activator inhibitor-1 (PAI-1) in the impaired bone repair process by using ...
Li Mao, Naoyuki Kawao, Yukinori Tamura, Katsumi Okumoto, Kiyotaka Okada, Masato Yano, Osamu Matsuo, Hiroshi Kaji   +7 more
doaj   +1 more source