Results 1 to 10 of about 107,995 (304)

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition [PDF]

Frontiers in Cardiovascular Medicine, 2020
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs).
Machteld Sillen, Paul J. Declerck
doaj   +5 more sources

Reversing PAI-1 deficiency in blood using mRNA lipid nanoparticles. [PDF]

Mol Ther Methods Clin Dev
Plasminogen activator inhibitor-1 (PAI-1) deficiency is a rare disorder that causes moderate to severe bleeding and cardiac fibrosis, caused by mutation in the SERPINE-1 gene and no detectable circulating PAI-1 protein.
Ferraresso F, Skaer CW, Badior K, Pulente SM, Paul M, Ketelboeter L, Chen THS, Cullis PR, Gupta S, Shapiro A, Mulvihill EE, Kastrup CJ.   +11 more
europepmc   +2 more sources

Overview: PAI-1 inhibitors and clinical applications. [PDF]

Biomed J
Plasminogen activator inhibitor-1 (PAI-1) is a protein involved in the fibrinolytic system and has been reported to be involved in various pathologies such as fibrosis and inflammation. We have developed small molecule inhibitors of human PAI-1 for clinical applications.
Miyata T.
europepmc   +3 more sources

Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundPlasminogen activator inhibitor type 1 (PAI‐1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI‐1 levels are associated with increased risk of coronary heart disease (CHD ...
Ci Song, Stephen Burgess, John D. Eicher, Christopher J. O'Donnell, Andrew D. Johnson   +4 more
doaj   +3 more sources

PAI-1 Exacerbates White Adipose Tissue Dysfunction and Metabolic Dysregulation in High Fat Diet-Induced Obesity

Frontiers in Pharmacology, 2018
Background: Plasminogen activator inhibitor (PAI)-1 levels and activity are known to increase during metabolic syndrome and obesity. In addition, previous studies have implicated PAI-1 in adipose tissue (AT) expansion while also contributing to insulin ...
Lin Wang, Lin Wang, Liyuan Chen, Liyuan Chen, Zheran Liu, Yaofang Liu, Mao Luo, Mao Luo, Ni Chen, Ni Chen, Xin Deng, Xin Deng, Yulin Luo, Yulin Luo, Jing He, Jing He, Liping Zhang, Liping Zhang, Michael A. Hill, Michael A. Hill, Michael A. Hill, Michael A. Hill, Rong Li, Rong Li, Jianbo Wu, Jianbo Wu, Jianbo Wu   +26 more
doaj   +3 more sources

Гарри Поттер как современный миф [PDF]

, 2011
Plasminogen activator inhibitor 1 (PAI-1), a major modulator of the fibrinolytic system, is an important factor in cardiovascular disease (CVD) susceptibility and severity.
Douglas E Vaughan, Folkert W Asselbergs, Jason H Moore, Marquitta J White, Nancy J Brown, Nuri M Kodaman, Reed H Harder, Scott M Williams   +7 more
core   +20 more sources

Influence of high intensity interval training on adipose tissue PAI-2 and MMP-2 mRNAs expression in rat with high-fat diet-induced metabolic syndrome [PDF]

Journal of Exercise & Organ Cross Talk, 2022
The aim of this study was to investigate the influence of high intensity interval training on adipose tissue PAI-2 and MMP-2 mRNAs expression in rat with high-fat diet-induced metabolic syndrome.
Mojgan Banihashemi, Ensiyeh Yazdkhasti, Maryam Mahmoudi Haghshenas, Fatemeh Rostamkhani   +3 more
doaj   +1 more source

Upaya Meningkatkan Hasil Belajar Siswa Kelas VIII A SMP Negeri 1 Buntulia Pada Mata Pelajaran Pendidikan Agama Islam Melalui Penerapan Model Pembelajaran Kooperatif tipe Think Talk Write

Aksara, 2021
Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) dengan mencoba menerapan salah satu model pembelajaran untuk mengaktifkansiswa dan mengefektifkan proses pembelajaran yaitu pembelajaran kooperatif tipe Think Talk Write.
Warni Diange
doaj   +1 more source

PAI-1 and kidney fibrosis [PDF]

Frontiers in Bioscience, 2009
Substantial evidence demonstrates a link of increased plasminogen activator inhibitor-1 (PAI-1) and glomerulosclerosis and kidney fibrosis, providing a novel therapeutic option for prevention and treatment of chronic kidney diseases. Several mechanisms contributing to increased PAI-1 will be addressed, including classic key profibrotic factors such as ...
Li-Jun, Ma, Agnes B, Fogo
openaire   +2 more sources

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses [PDF]

, 2020
The signalling pathways initiated by members of the transforming growth factor-β (TGFβ) family of cytokines control many metazoan cellular processes, including proliferation and differentiation, epithelial-mesenchymal transition (EMT) and apoptosis. TGFβ
A Rojas-Fernandez, A Woods, AR Ramjaun, AY Hsing, B Bierie, B Ozdamar, B-C Kim, BR Binder, C Allan, CJ David, CS Hill, DB Shackelford, EC Connolly, FA Ran, G Avery-Cooper, G Rena, G Rosti, GD Cuny, GJ Inman, GJ Inman, GM Keating, H Ikushima, J Massagué, J Massagué, J Massaous, J Ozanne, J Song, J Vogt, J Xu, JF Callahan, JL Wrana, JM Lizcano, Joan Massagué, JY Altarejos, K Clark, KA Brown, KJ Livak, LC Spender, LC Spender, M Abe, M Kowanetz, M Tojo, MO Li, MR Keeton, NJ Bright, P Lönn, PH Lin, PK Datta, PM Siegel, RJ Akhurst, RJ Akhurst, S DaCosta Byfield, S Dennler, S Edlund, S Strickson, SA Hawley, T Sonntag, TB Sundberg, Y Drabsch, Y Liu, Y Shi, Y Yang, Y Zhang, Y Zhang   +63 more
core   +2 more sources