Results 21 to 30 of about 136,040,587 (306)

Plasminogen activator inhibitor-1 in the evolution of stroke [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2004
Fibrinolytic activity in the acute stroke was examined by monitoring the level of plasminogen activator inhibitor-1 (PAI-1), as one of the indicators of fibrinolytic activity.
Jovanović Zagorka B., Ilić Mirka, Zidverc-Trajković Jasna, Pavlović Aleksandra M., Mijajlović Milija, Šternić-Čovičković Nadežda, Stanković Sanja, Beslać-Bumbaširević Ljiljana G., Kostić Vladimir S.   +8 more
doaj   +1 more source

Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum

Frontiers in Pharmacology, 2017
Traditional Chinese medicine has been used to treat a variety of human diseases for many centuries. Zanthoxylum nitidum var. tomentosum is used as an adjuvant to promote blood circulation and remove stasis.
Bo Yu, Guangping Zhang, Lingling Jin, Bo Zhang, Dong Yan, Hong Yang, Zuguang Ye, Tonghui Ma   +7 more
doaj   +1 more source

PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages

Laboratory Investigation, 2020
Cancer-associated fibroblasts (CAFs) contribute to the progression of various cancers. Previously, we reported the significance of CAFs in esophageal squamous cell carcinoma (ESCC); however, the functions of CAFs in the ESCC microenvironment remain ...
H. Sakamoto, Y. Koma, Nobuhide Higashino, T. Kodama, Kohei Tanigawa, Masaki Shimizu, M. Fujikawa, Mari Nishio, Manabu Shigeoka, Y. Kakeji, H. Yokozaki   +10 more
semanticscholar   +1 more source

Plasminogen influence on the PAI-1 release by human platelets [PDF]

The Ukrainian Biochemical Journal
РАІ-1 (plasminogen activator inhibitor type 1), as a major physiological inhibitor of tissue plasminogen activator and urokinase, plays a key role in the regulation of fibrinolysis in vivo.
O. I. Yusova , T. V. Grinenko, T. F. Drobot’ko , A. O. Tykhomyrov   +3 more
doaj   +1 more source

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

The relationship between plasminogen activator inhibitor-1 levels and the course of disease in COVID-19 patients

Türk Biyokimya Dergisi, 2022
Studies have shown that fibrinolysis activity is insufficient in COVID-19 patients. Plasminogen activator inhibitor-1 (PAI-1) is an important antifibrinolytic molecule that plays a key role in the fibrinolytic system.
Baltan Ecem, Serin Erdinç, Avci Burak Yasin, Akilli Işil Kibar, Çinar Ayşe Sürhan   +4 more
doaj   +1 more source

4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. [PDF]

, 2010
In Caucasian patients with severe sepsis due to pneumonia carriers of the 4G allele of PAI-1 polymorphism have higher risk for multiple organ dysfunction syndrome and septic shock and in agreement they showed more fulminant disease progression based on ...
Aladzsity, István, Prohászka Zoltán, Madách Krisztina, Füst György, Pénzes, István, Gál János, Pénzes István, Madách, Krisztina, Prohászka, Zoltán, Szilágyi Ágnes, Aladzsity István, Szilágyi, Agnes, Fust, George, Gál, János, János Gál, Ágnes Szilágyi, István Pénzes, George Fust, István Aladzsity, Zoltán Prohászka, Krisztina Madách   +20 more
core   +1 more source

Dual Diverse Dynamic Reversible Actions of Ankaferd on EPCR and PAI-1 Inside Vascular Endothelial Cells With and Without LPS

Turkish Journal of Hematology, 2012
OBJECTIVE: Ankaferd Blood Stopper (ABS) comprises a mixture of the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum ve Urtica dioica.
Afife Karabıyık, Erkan Yılmaz, Şükrü Güleç, İbrahim Haznedaroğlu, Nejat Akar   +4 more
doaj   +1 more source

Features of plasminogen activator inhibitor-1 synthesis by local fat depots of different localization in cardiovascular diseases

Российский кардиологический журнал, 2022
Aim. To determine the features of expression and secretion of plasminogen activator inhibitor-1 (PAI-1) by subcutaneous, epicardial and perivascular adipocytes depending on the complexity of coronary artery disease (CAD).Material and methods.
E. V. Belik, O. V. Gruzdeva, Yu. A. Dyleva, E. E. Bychkova, A. A. Kuzmina, S. V. Ivanov, O. L. Barbarash   +6 more
doaj   +1 more source

ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma

Cell Death and Disease, 2019
PAI-1 plays significant roles in cancer occurrence, relapse and multidrug resistance and is highly expressed in tumours. ACT001, which is currently in phase I clinical trials for the treatment of glioblastoma (GBM).
Xiaonan Xi, Ning Liu, Qian-Qian Wang, Yahui Chu, Zheng Yin, Ya-Hui Ding, Yaxin Lu   +6 more
semanticscholar   +1 more source