Results 21 to 30 of about 69,700 (263)

PAI-1 inhibits neutrophil efferocytosis [PDF]

Proceedings of the National Academy of Sciences, 2008
Phagocytosis of apoptotic cells, also called efferocytosis, is an essential feature of immune responses and critical for the resolution of inflammation. Plasma and tissue levels of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, are elevated in inflammatory conditions, including sepsis and acute lung injury,
Young-Jun, Park, Gang, Liu, Emmanuel F, Lorne, Xia, Zhao, Jing, Wang, Yuko, Tsuruta, Jaroslaw, Zmijewski, Edward, Abraham   +7 more
openaire   +2 more sources

The 4G/5G Polymorphism of Plasminogen Activator Inhibitor Type 1 is a Predictor of Moderate-to-Severe Thyroid Eye Disease

Journal of Inflammation Research, 2021
Monika Katko,1 Erika Galgoczi,1 Annamaria Erdei,1 Annamaria Gazdag,1 Eszter Berta,1 Miklos Bodor,1 Ildiko Seres,2 Ildiko Hircsu,1 Arpad Badics,1 Bernadett Ujhelyi,3 Livia Sira,1 Harjit Pal Bhattoa,4 Endre V Nagy1 1Division of Endocrinology, Department of
Katko M, Galgoczi E, Erdei A, Gazdag A, Berta E, Bodor M, Seres I, Hircsu I, Badics A, Ujhelyi B, Sira L, Bhattoa HP, Nagy EV   +12 more
doaj  

PAI-1-dependent endothelial cell death determines severity of radiation-induced intestinal injury. [PDF]

PLoS ONE, 2012
Normal tissue toxicity still remains a dose-limiting factor in clinical radiation therapy. Recently, plasminogen activator inhibitor type 1 (SERPINE1/PAI-1) was reported as an essential mediator of late radiation-induced intestinal injury. However, it is
Rym Abderrahmani, Agnes François, Valerie Buard, Georges Tarlet, Karl Blirando, Mohammad Hneino, Aurelie Vaurijoux, Marc Benderitter, Jean-Christophe Sabourin, Fabien Milliat   +9 more
doaj   +1 more source

Multifunctionality of PAI-1 in fibrogenesis: Evidence from obstructive nephropathy in PAI-1–overexpressing mice [PDF]

Kidney International, 2005
Plasminogen activator inhibitor-1 (PAI-1) has been implicated in the pathogenesis of chronic kidney disease based on its up-regulated expression and on the beneficial effects of PAI-1 inhibition or depletion in experimental models. PAI-1 is a multifunctional protein and the mechanisms that account for its profibrotic effects have not been fully ...
Matsuo, Shunya, Lepez-Guisa, JeseS M., Cai, Xiaohe, Okamura, Daryl M., Alpers, Charles E., Bumgarner, Roger E., Peters, Mette A., Zhang, Guoqiang, Eddy, Allison A.   +8 more
openaire   +2 more sources

Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice

Hepatology Communications, 2018
Plasminogen activator inhibitor 1 (PAI‐1), an essential regulator of fibrinolysis, is increasingly implicated in the pathogenesis of metabolic disorders, such as obesity and nonalcoholic fatty liver disease (NAFLD).
Anne S. Henkel, Sadiya S. Khan, Shantel Olivares, Toshio Miyata, Douglas E. Vaughan   +4 more
doaj   +1 more source

Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking. [PDF]

PLoS ONE, 2015
BACKGROUND:Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is expressed and secreted by endothelial cells. Patients with PAI-1 deficiency show a mild to moderate bleeding diathesis, which has been exclusively ascribed to the ...
Anna E Daniel, Ilse Timmerman, Igor Kovacevic, Peter L Hordijk, Luc Adriaanse, Ilkka Paatero, Heinz-Georg Belting, Jaap D van Buul   +7 more
doaj   +1 more source

The role of the platelet pool of Plasminogen Activator Inhibitor-1 in well-controlled type 2 diabetes patients.

PLoS ONE, 2022
BackgroundThe main inhibitor of the fibrinolytic system, Plasminogen Activator Inhibitor -1 (PAI-1), irreversibly binds tissue-type Plasminogen Activator (t-PA) and thereby inhibits the protective action of tPA against thrombus formation. Elevated levels
Karin Mossberg, Josefin Olausson, Emanuel Fryk, Sverker Jern, Per-Anders Jansson, Helén Brogren   +5 more
doaj   +1 more source

PAI-1 Overexpression in Valvular Interstitial Cells Contributes to Hypofibrinolysis in Aortic Stenosis

Cells, 2023
Aortic stenosis (AS) is associated with hypofibrinolysis, but its mechanism is poorly understood. We investigated whether LDL cholesterol affects plasminogen activator inhibitor 1 (PAI-1) expression, which may contribute to hypofibrinolysis in AS ...
Magdalena Kopytek, Michał Ząbczyk, Piotr Mazur, Anetta Undas, Joanna Natorska   +4 more
doaj   +1 more source

PAI‐1 stability: the role of histidine residues [PDF]

FEBS Letters, 2000
The role of the 13 histidine residues in plasminogen activator inhibitor 1 (PAI‐1) for the stability of the molecule was studied by replacing these residues by threonine, using site‐directed mutagenesis. The generated mutants were expressed in Escherichia coli, purified and characterized.
Mångs, Helena, Sui, Guang-Chao, Wiman, Björn   +2 more
openaire   +2 more sources

Plasminogen Activator Inhibitor-1 Regulates LPS Induced Inflammation in Rat Macrophages through Autophagy Activation

The Scientific World Journal, 2014
Background. The mechanisms by which plasminogen activator inhibitor-1 (PAI-1) regulates inflammation, especially in acute respiratory distress syndrome (ARDS), are largely unknown. Objective.
Zhong-Hui Wang, Wei-Ying Ren, Lei Zhu, Li-Juan Hu   +3 more
doaj   +1 more source