Results 41 to 50 of about 136,040,587 (306)

A signaling pathway map of plasminogen activator inhibitor-1 (PAI-1/SERPINE-1): a review of an innovative frontier in molecular aging and cellular senescence

Cell Communication and Signaling
Plasminogen activator inhibitor-1 (PAI-1) is a vital regulator of the fibrinolytic mechanism and has been intricately involved in various physiological and clinical processes, including cancer, thrombosis, and wound healing.
S. Shaikh, Rex Devasahayam Arokia Balaya, Shobha Dagamajalu, Y. Bhandary, H. Unwalla, T. S. K. Prasad, Irfan Rahman   +6 more
semanticscholar   +1 more source

Doma Menorquina y Doma Clásica [PDF]

, 2017
Ministerio de Agricultura, alimentación y medio ambiente PAI-AGR-158Ministerio de Agricultura, alimentación y medio ambiente PAI-AGR-273Consell Insular de ...
Negro Rama, Sara, Sánchez Guerrero, María José, Poyato Bonilla, Julia, Bartolomé Medina, Ester, Valera Córdoba, María Mercedes, Gómez Ortiz, María Dolores   +5 more
core   +2 more sources

Stress granules counteract senescence by sequestration of PAI‐1

EMBO Reports, 2018
Cellular senescence is a physiological response by which an organism halts the proliferation of potentially harmful and damaged cells. However, the accumulation of senescent cells over time can become deleterious leading to diseases and physiological ...
A. Omer, Devang Patel, Xian J. Lian, Jason Sadek, Sergio Di Marco, A. Pause, M. Gorospe, I. Gallouzi   +7 more
semanticscholar   +1 more source

PAI-1_act, PAI-1_ag, tPA/PAI-1 complex and CLT according to βTG quartiles in SABPA study group.

, 2017
PAI-1act, PAI-1ag, tPA/PAI-1 complex and CLT according to βTG quartiles in SABPA study group.
Marlien Pieters (299650), Du Toit Loots (3716449), Sunelle A. Barnard (3716446), Dingeman C. Rijken (299652)   +3 more
core   +1 more source

Plasminogen Activator Inhibitor-1 Regulates LPS Induced Inflammation in Rat Macrophages through Autophagy Activation

The Scientific World Journal, 2014
Background. The mechanisms by which plasminogen activator inhibitor-1 (PAI-1) regulates inflammation, especially in acute respiratory distress syndrome (ARDS), are largely unknown. Objective.
Zhong-Hui Wang, Wei-Ying Ren, Lei Zhu, Li-Juan Hu   +3 more
doaj   +1 more source

High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction [PDF]

Journal of Exercise & Organ Cross Talk
Metabolic syndrome (MetS) elevates thrombotic risk through dysregulated coagulation factors, including plasminogen activator inhibitor-1 (PAI-1) and fibrinogen, driven by visceral adiposity and metabolic dysfunction.
Niyousha Ghazbani, Arezoo Razmdideh, Amin Alimohammadi, Danial Bagherzadeh, Ehsan Rezaee Moeini, Mohammad Reza Mozaffari, Mohammad Sadra Roshani Koosha   +6 more
doaj   +1 more source

PAI-1 contributes to homocysteine-induced cellular senescence

Cellular Signalling, 2019
Cellular Senescence is associated with organismal aging and related pathologies. Previously, we reported that plasminogen activator inhibitor-1 (PAI-1) is an essential mediator of senescence and a potential therapeutic target for preventing aging-related
T. Sun, A. Ghosh, M. Eren, T. Miyata, D. Vaughan   +4 more
semanticscholar   +1 more source

Overwhelming tPA Release, not PAI-1 Degradation, is Responsible for Hyperfibrinolysis in Severely Injured Trauma Patients

Journal of Trauma and Acute Care Surgery, 2016
BACKGROUND Trauma-induced coagulopathy (TIC) is associated with a fourfold increased risk of mortality. Hyperfibrinolysis is a component of TIC, but its mechanism is poorly understood.
M. P. Chapman, E. Moore, H. Moore, E. Gonzalez, F. Gamboni, James G. Chandler, Sanchayita Mitra, A. Ghasabyan, T. Chin, A. Sauaia, A. Banerjee, C. Silliman   +11 more
semanticscholar   +1 more source

ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression. [PDF]

, 2020
Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked fibrosis and low immunogenicity, features that are linked to treatment resistance and poor clinical outcomes.
Simon, Hans-Uwe, Rossi Sebastiano, Matteo, Peng, Ren-Wang, Pozzato, Chiara, Saliakoura, Maria, Oberson, Kevin, Karamitopoulou, Evanthia, Yang, Zhang, Konstantinidou, Georgia, Konstantinidou G, Simon HU, Oberson K, Karamitopoulou E, Rossi Sebastiano M, Sebastiano, M. R., Yang Z, Yang, Z., Pozzato C, Galiè M, Saliakoura M, Peng RW, Maria Saliakoura, Matteo Rossi Sebastiano, Evanthia Karamitopoulou, Chiara Pozzato, Georgia Konstantinidou, Galiè, Mirco, Mirco Galiè, Kevin Oberson, Ren-Wang Peng, Zhang, Yang, Hans-Uwe Simon, Zhang Yang   +32 more
core   +2 more sources

Urokinase-Type Plasminogen Activator System in Norm and in Life-Threatening Processes (Review)

Общая реаниматология, 2018
The multifunctional urokinase-type plasminogen activator system (uPA-system) includes serine proteinase — uPA or urokinase, its receptor (uPAR) and two inhibitors (PAI-1 and PAI-2).
Elena V. Kugaevskaya, Tatiana A. Gureeva, Olga S. Timoshenko, Nina I. Solovyeva   +3 more
doaj   +1 more source