Results 31 to 40 of about 107,995 (304)

Possible effect of genetic background in thrombophilia genes on clinical severity of patients with coronavirus disease-2019: A prospective cohort study

Baghdad Journal of Biochemistry and Applied Biological Sciences, 2022
Background and objective: Thrombotic and microangiopathic effects have been reported in Coronavirus Disease-2019 (COVID-19) patients. In the present study, we aimed to examine the relationship between hereditary thrombophilia factors and the clinical ...
Ozlem Sezer, Ozgur Gunal, Recai Aci, Adem Keskin   +3 more
doaj   +1 more source

Plasminogen activator inhibitor-1 in the evolution of stroke [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2004
Fibrinolytic activity in the acute stroke was examined by monitoring the level of plasminogen activator inhibitor-1 (PAI-1), as one of the indicators of fibrinolytic activity.
Jovanović Zagorka B., Ilić Mirka, Zidverc-Trajković Jasna, Pavlović Aleksandra M., Mijajlović Milija, Šternić-Čovičković Nadežda, Stanković Sanja, Beslać-Bumbaširević Ljiljana G., Kostić Vladimir S.   +8 more
doaj   +1 more source

The effect of thyroid hormones on the white adipose tissue gene expression of PAI-1 and its serum concentration [PDF]

, 2009
Metabolic syndrome is associated with an increased risk of developing cardiovascular diseases and Plasminogen activator inhibitor 1 (PAI-1) overexpression may play a significant role in this process.
Biz, Carolina, Mattos, Ana Barbosa Marcondes de, Nascimento, Claudia Maria da Penha Oller do, Oliveira, Cristiane de, Oliveira, Juliana de., Oyama, Lila Missae, Ribeiro, Eliane Beraldi   +6 more
core   +1 more source

Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients [PDF]

, 2002
BACKGROUND: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients ...
Beex, L.V. (Louk), Bendahl, P.O., Blankenstein, M.A. (Marinus), Borstnar, S., Broet, P., Brunner, N., Christensen, I.J., Cufer, T., Daver, A., Daxenbichler, G., Duffy, M.J. (Michael), Duggan, C., Eppenberger, U., Eppenberger-Castori, S. (Serenella), Ferno, M., Fiets, W.E., Foekens, J.A. (John), Harbeck, N. (Nadia), Janicke, F., Kates, R. (Ronald), Klijn, J.G.M. (Jan), Kueng, W., Lisboa, B.W., Look, M.P. (Maxime), Magdelenat, H., Manders, P. (Peggy), Martin, P.M., Meijer van Gelder, M.E. (Marion), O'Higgins, N., Peyrat , J.P., Putten, W.L.J. (Wim) van, Quillien, V., Ricolleau, G., Romain, S., Schmitt, M. (Manfred), Spyratos, F., Sweep, C.G., Thomssen, C. (Christoph), Ulm, K., Windbichler, G.   +39 more
core   +1 more source

The 4G/5G Polymorphism of Plasminogen Activator Inhibitor Type 1 is a Predictor of Moderate-to-Severe Thyroid Eye Disease

Journal of Inflammation Research, 2021
Monika Katko,1 Erika Galgoczi,1 Annamaria Erdei,1 Annamaria Gazdag,1 Eszter Berta,1 Miklos Bodor,1 Ildiko Seres,2 Ildiko Hircsu,1 Arpad Badics,1 Bernadett Ujhelyi,3 Livia Sira,1 Harjit Pal Bhattoa,4 Endre V Nagy1 1Division of Endocrinology, Department of
Katko M, Galgoczi E, Erdei A, Gazdag A, Berta E, Bodor M, Seres I, Hircsu I, Badics A, Ujhelyi B, Sira L, Bhattoa HP, Nagy EV   +12 more
doaj  

Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism and endometriosis. Influence of PAI-1 polymorphism on PAI-1 antigen and mRNA expression

Thrombosis Research, 2008
Endometriosis is a benign gynecologic disease with a high prevalence. It is a multifactorial and polygenic entity in which the fibrinolytic system may be implicated. The objective of this study was to evaluate the plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in a group of women with and without endometriosis and to analyze the influence
Ramírez P, Gilabert-Estelles, Juan, Cosin, Raul, Gilabert, Juan, Espana, Francisco, Castello, Remedios, Chirivella, Melitina, Romeu, Alberto, Estelles, Amparo   +8 more
openaire   +4 more sources

Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice

Hepatology Communications, 2018
Plasminogen activator inhibitor 1 (PAI‐1), an essential regulator of fibrinolysis, is increasingly implicated in the pathogenesis of metabolic disorders, such as obesity and nonalcoholic fatty liver disease (NAFLD).
Anne S. Henkel, Sadiya S. Khan, Shantel Olivares, Toshio Miyata, Douglas E. Vaughan   +4 more
doaj   +1 more source

Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells [PDF]

, 2009
We analyzed the secretory dynamics of tissue plasminogen activator (tPA) in EA.hy926 cells, an established vascular endothelial cell (VEC) line producing GFP-tagged tPA, using total internal reflection fluorescence (TIR-F) microscopy.
2722, 2723, 2724, 2725, Ihara, Hayato, Mogami, Hideo, Suzuki, Yuko, Urano, Tetsumei   +7 more
core   +2 more sources

The relationship between plasminogen activator inhibitor-1 levels and the course of disease in COVID-19 patients

Türk Biyokimya Dergisi, 2022
Studies have shown that fibrinolysis activity is insufficient in COVID-19 patients. Plasminogen activator inhibitor-1 (PAI-1) is an important antifibrinolytic molecule that plays a key role in the fibrinolytic system.
Baltan Ecem, Serin Erdinç, Avci Burak Yasin, Akilli Işil Kibar, Çinar Ayşe Sürhan   +4 more
doaj   +1 more source

PAI-1 augments mucosal damage in colitis [PDF]

Science Translational Medicine, 2019
SERPINE1/PAI-1 is elevated in the colon tissue of the most difficult-to-treat patients with IBD and leads to worsening of experimental colitis.
Gerard E. Kaiko, Feidi Chen, Chin-Wen Lai, I-Ling Chiang, Jacqueline Perrigoue, Aleksandar Stojmirović, Katherine Li, Brian D. Muegge, Umang Jain, Kelli L. VanDussen, Bridie J. Goggins, Simon Keely, Jessica Weaver, Paul S. Foster, Daniel A. Lawrence, Ta-Chiang Liu, Thaddeus S. Stappenbeck   +16 more
openaire   +2 more sources