Results 31 to 40 of about 136,040,587 (306)

PAI-1 is a Marker and a Mediator of Senescence

Arteriosclerosis, Thrombosis and Vascular Biology, 2017
Plasminogen Activator Inhibitor-1 (PAI-1) is a member of the evolutionarily conserved serine protease inhibitor (SERPIN) family, and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators.
D. Vaughan, R. Rai, S. Khan, M. Eren, A. Ghosh   +4 more
semanticscholar   +1 more source

The 4G/5G Polymorphism of Plasminogen Activator Inhibitor Type 1 is a Predictor of Moderate-to-Severe Thyroid Eye Disease

Journal of Inflammation Research, 2021
Monika Katko,1 Erika Galgoczi,1 Annamaria Erdei,1 Annamaria Gazdag,1 Eszter Berta,1 Miklos Bodor,1 Ildiko Seres,2 Ildiko Hircsu,1 Arpad Badics,1 Bernadett Ujhelyi,3 Livia Sira,1 Harjit Pal Bhattoa,4 Endre V Nagy1 1Division of Endocrinology, Department of
Katko M, Galgoczi E, Erdei A, Gazdag A, Berta E, Bodor M, Seres I, Hircsu I, Badics A, Ujhelyi B, Sira L, Bhattoa HP, Nagy EV   +12 more
doaj  

Cisplatin-activated PAI-1 secretion in the cancer-associated fibroblasts with paracrine effects promoting esophageal squamous cell carcinoma progression and causing chemoresistance

Cell Death and Disease, 2018
Preoperative chemotherapy is a promising strategy for the treatment of esophageal squamous cell carcinoma (ESCC). Acquired resistance to chemotherapy is a major obstacle in improving patient prognosis. Cancer-associated fibroblasts (CAFs) are the primary
Y. Che, Jing-Nan Wang, Yuan Li, Zhi-Liang Lu, Jian-Bing Huang, Shou-Guo Sun, Shuang-Shuang Mao, Yuan-Yuan Lei, Ruo-Chuan Zang, N. Sun, Jie He   +10 more
semanticscholar   +1 more source

PAI-1-dependent endothelial cell death determines severity of radiation-induced intestinal injury. [PDF]

PLoS ONE, 2012
Normal tissue toxicity still remains a dose-limiting factor in clinical radiation therapy. Recently, plasminogen activator inhibitor type 1 (SERPINE1/PAI-1) was reported as an essential mediator of late radiation-induced intestinal injury. However, it is
Rym Abderrahmani, Agnes François, Valerie Buard, Georges Tarlet, Karl Blirando, Mohammad Hneino, Aurelie Vaurijoux, Marc Benderitter, Jean-Christophe Sabourin, Fabien Milliat   +9 more
doaj   +1 more source

The role of the platelet pool of Plasminogen Activator Inhibitor-1 in well-controlled type 2 diabetes patients.

PLoS ONE, 2022
BackgroundThe main inhibitor of the fibrinolytic system, Plasminogen Activator Inhibitor -1 (PAI-1), irreversibly binds tissue-type Plasminogen Activator (t-PA) and thereby inhibits the protective action of tPA against thrombus formation. Elevated levels
Karin Mossberg, Josefin Olausson, Emanuel Fryk, Sverker Jern, Per-Anders Jansson, Helén Brogren   +5 more
doaj   +1 more source

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

Biomolecules, 2019
Stress-induced premature cellular senescence is a significant factor in the onset of age-dependent disease in the cardiovascular system. Plasminogen activator inhibitor-1 (PAI-1), a major TGF-β1/p53 target gene and negative regulator of the plasmin-based
R. Samarakoon, Stephen P. Higgins, Craig E. Higgins, P. Higgins   +3 more
semanticscholar   +1 more source

Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice

Hepatology Communications, 2018
Plasminogen activator inhibitor 1 (PAI‐1), an essential regulator of fibrinolysis, is increasingly implicated in the pathogenesis of metabolic disorders, such as obesity and nonalcoholic fatty liver disease (NAFLD).
Anne S. Henkel, Sadiya S. Khan, Shantel Olivares, Toshio Miyata, Douglas E. Vaughan   +4 more
doaj   +1 more source

Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking. [PDF]

PLoS ONE, 2015
BACKGROUND:Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is expressed and secreted by endothelial cells. Patients with PAI-1 deficiency show a mild to moderate bleeding diathesis, which has been exclusively ascribed to the ...
Anna E Daniel, Ilse Timmerman, Igor Kovacevic, Peter L Hordijk, Luc Adriaanse, Ilkka Paatero, Heinz-Georg Belting, Jaap D van Buul   +7 more
doaj   +1 more source

PAI-1 augments mucosal damage in colitis

Science Translational Medicine, 2019
SERPINE1/PAI-1 is elevated in the colon tissue of the most difficult-to-treat patients with IBD and leads to worsening of experimental colitis. A punch to the gut by PAI-1 Only a fraction of patients with inflammatory bowel disease (IBD) respond to ...
G. Kaiko, Fei-Di Chen, Chin-Wen Lai, I-Ling Chiang, J. Perrigoue, A. Stojmirović, Katherine Li, B. Muegge, Umang Jain, K. VanDussen, Bridie J. Goggins, S. Keely, J. Weaver, P. Foster, D. Lawrence, Ta-Chiang Liu, T. Stappenbeck   +16 more
semanticscholar   +1 more source

PAI-1 Overexpression in Valvular Interstitial Cells Contributes to Hypofibrinolysis in Aortic Stenosis

Cells, 2023
Aortic stenosis (AS) is associated with hypofibrinolysis, but its mechanism is poorly understood. We investigated whether LDL cholesterol affects plasminogen activator inhibitor 1 (PAI-1) expression, which may contribute to hypofibrinolysis in AS ...
Magdalena Kopytek, Michał Ząbczyk, Piotr Mazur, Anetta Undas, Joanna Natorska   +4 more
doaj   +1 more source