Results 11 to 20 of about 69,700 (263)

Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model

Journal of Translational Medicine, 2020
Background Accumulating evidence suggests that plasminogen activator inhibitor-1 (PAI-1) plays an important role in bladder tumorigenesis by regulating cell cycle.
Hideki Furuya, Kazukuni Hayashi, Yoshiko Shimizu, Nari Kim, Yutaro Tsukikawa, Runpu Chen, Yijun Sun, Owen T. M. Chan, Ian Pagano, Rafael Peres, Kanani Hokutan, Fumie Igari, Keith S. Chan, Charles J. Rosser   +13 more
doaj   +1 more source

Possible effect of genetic background in thrombophilia genes on clinical severity of patients with coronavirus disease-2019: A prospective cohort study

Baghdad Journal of Biochemistry and Applied Biological Sciences, 2022
Background and objective: Thrombotic and microangiopathic effects have been reported in Coronavirus Disease-2019 (COVID-19) patients. In the present study, we aimed to examine the relationship between hereditary thrombophilia factors and the clinical ...
Ozlem Sezer, Ozgur Gunal, Recai Aci, Adem Keskin   +3 more
doaj   +1 more source

Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum

Frontiers in Pharmacology, 2017
Traditional Chinese medicine has been used to treat a variety of human diseases for many centuries. Zanthoxylum nitidum var. tomentosum is used as an adjuvant to promote blood circulation and remove stasis.
Bo Yu, Guangping Zhang, Lingling Jin, Bo Zhang, Dong Yan, Hong Yang, Zuguang Ye, Tonghui Ma   +7 more
doaj   +1 more source

PAI‐1 and atherothrombosis [PDF]

Journal of Thrombosis and Haemostasis, 2005
Plasminogen activator inhibitor-1 (PAI-1) is the major physiologic inhibitor of tissue-type plasminogen activator in plasma, and is elevated in a variety of clinical situations that are associated with increased risk of ischemic cardiovascular events. Recent insights into the biology of PAI-1 suggest that it is more than just an innocent bystander in ...
openaire   +2 more sources

Plasminogen activator inhibitor-1 in the evolution of stroke [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2004
Fibrinolytic activity in the acute stroke was examined by monitoring the level of plasminogen activator inhibitor-1 (PAI-1), as one of the indicators of fibrinolytic activity.
Jovanović Zagorka B., Ilić Mirka, Zidverc-Trajković Jasna, Pavlović Aleksandra M., Mijajlović Milija, Šternić-Čovičković Nadežda, Stanković Sanja, Beslać-Bumbaširević Ljiljana G., Kostić Vladimir S.   +8 more
doaj   +1 more source

Plasminogen influence on the PAI-1 release by human platelets [PDF]

The Ukrainian Biochemical Journal
РАІ-1 (plasminogen activator inhibitor type 1), as a major physiological inhibitor of tissue plasminogen activator and urokinase, plays a key role in the regulation of fibrinolysis in vivo.
O. I. Yusova , T. V. Grinenko, T. F. Drobot’ko , A. O. Tykhomyrov   +3 more
doaj   +1 more source

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

The relationship between plasminogen activator inhibitor-1 levels and the course of disease in COVID-19 patients

Türk Biyokimya Dergisi, 2022
Studies have shown that fibrinolysis activity is insufficient in COVID-19 patients. Plasminogen activator inhibitor-1 (PAI-1) is an important antifibrinolytic molecule that plays a key role in the fibrinolytic system.
Baltan Ecem, Serin Erdinç, Avci Burak Yasin, Akilli Işil Kibar, Çinar Ayşe Sürhan   +4 more
doaj   +1 more source

Dual Diverse Dynamic Reversible Actions of Ankaferd on EPCR and PAI-1 Inside Vascular Endothelial Cells With and Without LPS

Turkish Journal of Hematology, 2012
OBJECTIVE: Ankaferd Blood Stopper (ABS) comprises a mixture of the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum ve Urtica dioica.
Afife Karabıyık, Erkan Yılmaz, Şükrü Güleç, İbrahim Haznedaroğlu, Nejat Akar   +4 more
doaj   +1 more source

Features of plasminogen activator inhibitor-1 synthesis by local fat depots of different localization in cardiovascular diseases

Российский кардиологический журнал, 2022
Aim. To determine the features of expression and secretion of plasminogen activator inhibitor-1 (PAI-1) by subcutaneous, epicardial and perivascular adipocytes depending on the complexity of coronary artery disease (CAD).Material and methods.
E. V. Belik, O. V. Gruzdeva, Yu. A. Dyleva, E. E. Bychkova, A. A. Kuzmina, S. V. Ivanov, O. L. Barbarash   +6 more
doaj   +1 more source