Results 11 to 20 of about 136,040,587 (306)

Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1

EMBO Molecular Medicine, 2021
The mechanisms underlying the development of glomerular lesions during aging are largely unknown. It has been suggested that senescence might play a role, but the pathophysiological link between senescence and lesion development remains unexplained. Here,
Camille Cohen, Océane Le Goff, F. Soysouvanh, F. Vasseur, Marine Tanou, Clément Nguyen, L. Amrouche, J. Le Guen, Oriana Saltel-Fulero, T. Meunier, T. Nguyen-Khoa, M. Rabant, D. Nochy, C. Legendre, G. Friedlander, Bennett G. Childs, Darren J. Baker, B. Knebelmann, D. Anglicheau, F. Milliat, F. Terzi   +20 more
semanticscholar   +1 more source

PAI-1 inhibitor TM5614 leads osteosarcoma cells to G2 arrest [PDF]

, 2023
Osteosarcoma is a malignant tumor that histologi- cally forms a tumor-like osteoid or bone. Plasmino- gen activator inhibitor 1 (PAI-1) is highly expressed in the blood of patients with various malignant tumors or in the tumors themselves, and its expres-
Gilinazi Anniwaer, Kunikazu Tsuji, Shingo Sato, Atsushi Okawa, Toshio Miyata, Yoshinori Asou   +5 more
core   +1 more source

Increased PAI-1 plasma levels and risk of death from dengue: no association with the 4G/5G promoter polymorphism [PDF]

, 2005
Background: Dengue virus infected patients have high plasminogen activator inhibitor type I (PAI-1) plasma concentrations. Whether the insertion/deletion (4G/5G) polymorphism in the promotor region of the PAI-1 gene is associated with increased PAI-1 ...
ten Cate, H, Brandjes, DPM, Hack, C. Erik, Mairuhu, ATA, Leyte, A, Osterhaus, ADME, Faradz, Sultana M.H., Reitsma, PH, Setiati, Tatty E., van Gorp, Eric C. M., Koraka, P   +10 more
core   +2 more sources

PAI-1 is a novel component of the miR-17~92 signaling that regulates pulmonary artery smooth muscle cell phenotypes [PDF]

, 2018
We have previously reported that miR-17~92 is critically involved in the pathogenesis of pulmonary hypertension (PH). We also identified two novel mR-17/20a direct targets, PDZ and LIM domain protein 5 (PDLIM5) and prolyl hydroxylase 2 (PHD2), and ...
Tianji Chen, Tianji Chen (680509), J. Usha Raj, Jingbo Dai (7925756), J. Usha Raj (7925720), Jason B. Huang, Jingbo Dai, Guofei Zhou (680513), Guofei Zhou, Jason B. Huang (7925753), Qiyuan Zhou (680508), Qiyuan Zhou   +11 more
core   +3 more sources

Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. [PDF]

PLoS ONE, 2015
Sepsis-induced acute kidney injury (AKI) contributes to the high mortality and morbidity in patients. Although the pathogenesis of AKI during sepsis is poorly understood, it is well accepted that plasminogen activator inhibitor-1 (PAI-1) and vitronectin (
Kamlesh K Gupta, Deborah L Donahue, Mayra J Sandoval-Cooper, Francis J Castellino, Victoria A Ploplis   +4 more
doaj   +1 more source

Plasminogen activator inhibitor-1 is involved in impaired bone repair associated with diabetes in female mice. [PDF]

PLoS ONE, 2014
Previous studies suggest that fracture healing is impaired in diabetes; however, the underlying mechanism remains unclear. Here, we investigated the roles of plasminogen activator inhibitor-1 (PAI-1) in the impaired bone repair process by using ...
Li Mao, Naoyuki Kawao, Yukinori Tamura, Katsumi Okumoto, Kiyotaka Okada, Masato Yano, Osamu Matsuo, Hiroshi Kaji   +7 more
doaj   +1 more source

Plasminogen Activating Inhibitor-1 Might Predict the Efficacy of Anti-PD1 Antibody in Advanced Melanoma Patients

Frontiers in Oncology, 2021
Plasminogen activating inhibitor-1 (PAI-1) plays crucial roles in the development of various cancers, including melanomas. Indeed, various pro-tumorigenic functions of PAI-1 in cancer progression and metastasis have been widely reported.
Kentaro Ohuchi, Yumi Kambayashi, Takanori Hidaka, Taku Fujimura   +3 more
doaj   +1 more source

Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model

Journal of Translational Medicine, 2020
Background Accumulating evidence suggests that plasminogen activator inhibitor-1 (PAI-1) plays an important role in bladder tumorigenesis by regulating cell cycle.
Hideki Furuya, Kazukuni Hayashi, Yoshiko Shimizu, Nari Kim, Yutaro Tsukikawa, Runpu Chen, Yijun Sun, Owen T. M. Chan, Ian Pagano, Rafael Peres, Kanani Hokutan, Fumie Igari, Keith S. Chan, Charles J. Rosser   +13 more
doaj   +1 more source

Possible effect of genetic background in thrombophilia genes on clinical severity of patients with coronavirus disease-2019: A prospective cohort study

Baghdad Journal of Biochemistry and Applied Biological Sciences, 2022
Background and objective: Thrombotic and microangiopathic effects have been reported in Coronavirus Disease-2019 (COVID-19) patients. In the present study, we aimed to examine the relationship between hereditary thrombophilia factors and the clinical ...
Ozlem Sezer, Ozgur Gunal, Recai Aci, Adem Keskin   +3 more
doaj   +1 more source

PAI-1, the Plasminogen System, and Skeletal Muscle

International Journal of Molecular Sciences, 2020
The plasminogen system is a critical proteolytic system responsible for the remodeling of the extracellular matrix (ECM). The master regulator of the plasminogen system, plasminogen activator inhibitor-1 (PAI-1), has been implicated for its role in ...
F. Rahman, M. Krause
semanticscholar   +1 more source