Results 11 to 20 of about 107,995 (304)

Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. [PDF]

PLoS ONE, 2015
Sepsis-induced acute kidney injury (AKI) contributes to the high mortality and morbidity in patients. Although the pathogenesis of AKI during sepsis is poorly understood, it is well accepted that plasminogen activator inhibitor-1 (PAI-1) and vitronectin (
Kamlesh K Gupta, Deborah L Donahue, Mayra J Sandoval-Cooper, Francis J Castellino, Victoria A Ploplis   +4 more
doaj   +1 more source

PAI‐1 in tissue fibrosis [PDF]

Journal of Cellular Physiology, 2011
AbstractFibrosis is defined as a fibroproliferative or abnormal fibroblast activation‐related disease. Deregulation of wound healing leads to hyperactivation of fibroblasts and excessive accumulation of extracellular matrix (ECM) proteins in the wound area, the pathological manifestation of fibrosis.
Asish K, Ghosh, Douglas E, Vaughan
openaire   +2 more sources

Plasminogen Activating Inhibitor-1 Might Predict the Efficacy of Anti-PD1 Antibody in Advanced Melanoma Patients

Frontiers in Oncology, 2021
Plasminogen activating inhibitor-1 (PAI-1) plays crucial roles in the development of various cancers, including melanomas. Indeed, various pro-tumorigenic functions of PAI-1 in cancer progression and metastasis have been widely reported.
Kentaro Ohuchi, Yumi Kambayashi, Takanori Hidaka, Taku Fujimura   +3 more
doaj   +1 more source

PAI-1 inhibits neutrophil efferocytosis [PDF]

Proceedings of the National Academy of Sciences, 2008
Phagocytosis of apoptotic cells, also called efferocytosis, is an essential feature of immune responses and critical for the resolution of inflammation. Plasma and tissue levels of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, are elevated in inflammatory conditions, including sepsis and acute lung injury,
Young-Jun, Park, Gang, Liu, Emmanuel F, Lorne, Xia, Zhao, Jing, Wang, Yuko, Tsuruta, Jaroslaw, Zmijewski, Edward, Abraham   +7 more
openaire   +2 more sources

Plasminogen activator inhibitor-1 is involved in impaired bone repair associated with diabetes in female mice. [PDF]

PLoS ONE, 2014
Previous studies suggest that fracture healing is impaired in diabetes; however, the underlying mechanism remains unclear. Here, we investigated the roles of plasminogen activator inhibitor-1 (PAI-1) in the impaired bone repair process by using ...
Li Mao, Naoyuki Kawao, Yukinori Tamura, Katsumi Okumoto, Kiyotaka Okada, Masato Yano, Osamu Matsuo, Hiroshi Kaji   +7 more
doaj   +1 more source

Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model

Journal of Translational Medicine, 2020
Background Accumulating evidence suggests that plasminogen activator inhibitor-1 (PAI-1) plays an important role in bladder tumorigenesis by regulating cell cycle.
Hideki Furuya, Kazukuni Hayashi, Yoshiko Shimizu, Nari Kim, Yutaro Tsukikawa, Runpu Chen, Yijun Sun, Owen T. M. Chan, Ian Pagano, Rafael Peres, Kanani Hokutan, Fumie Igari, Keith S. Chan, Charles J. Rosser   +13 more
doaj   +1 more source

Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum

Frontiers in Pharmacology, 2017
Traditional Chinese medicine has been used to treat a variety of human diseases for many centuries. Zanthoxylum nitidum var. tomentosum is used as an adjuvant to promote blood circulation and remove stasis.
Bo Yu, Guangping Zhang, Lingling Jin, Bo Zhang, Dong Yan, Hong Yang, Zuguang Ye, Tonghui Ma   +7 more
doaj   +1 more source

Clinical and genetic aspects of menopausal hormone therapy - a modern paradigm. What changed COVID-19 pandemic?

RUDN Journal of Medicine, 2022
In the modern paradigm of public health protection, much attention is paid to the health of women in peri- and postmenopause, and a personalized approach prevails.
Irina S. Zhuravleva, Marina B. Khamoshina, Mekan R. Orazov, Elena M. Dmitrieva, Madina M. Azova   +4 more
doaj   +1 more source

Effect of dsRNA on Mesangial Cell Synthesis of Plasminogen Activator Inhibitor Type 1 and Tissue Plasminogen Activator [PDF]

, 2009
Background/Aims: Viral infections are a major problem worldwide and many of them are complicated by virally induced glomerulonephritides. Progression of kidney disease to renal failure is mainly attributed to the development of renal fibrosis ...
Merkle, Monika, Ribeiro, Andrea, Roeder, Maximilian, Sauter, Matthias, Wörnle, Markus   +4 more
core   +1 more source

Increased hazard of myocardial infarction with insulin‐provision therapy in actively smoking patients with diabetes mellitus and stable ischemic heart disease: The BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial [PDF]

, 2017
Background In the BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial, randomization of diabetic patients with stable ischemic heart disease to insulin provision ( IP
Brown, David L, Chung, Matthew J, Khan, Asrar A, Novak, Eric   +3 more
core   +2 more sources