Vitronectin in human breast carcinomas
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2003 We have analysed the occurrence of the extracellular glycoprotein vitronectin in carcinomas and normal tissue of human breast. Immunohistochemical analysis of carcinomas revealed a strong vitronectin accumulation in extracellular matrix (ECM) around some cancer cell clusters and in the subendothelial area of some blood vessels.
Peter A Andreasen, Anni Christensen
exaly +4 more sources
Interaction of late apoptotic and necrotic cells with vitronectin. [PDF]
PLoS ONE, 2011 BACKGROUND: Vitronectin is an abundant plasma glycoprotein identified also as a part of extracellular matrix. Vitronectin is substantially enriched at sites of injured, fibrosing, inflamed, and tumor tissues where it is believed to be involved in wound ...
Ondrej Stepanek +7 more
doaj +1 more source
Vitronectin expression in the airways of subjects with asthma and chronic obstructive pulmonary disease. [PDF]
PLoS ONE, 2015 Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling.
Lina M Salazar-Peláez +6 more
doaj +1 more source
Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif. [PDF]
PLoS ONE, 2016 Pathogenicity of many microbes relies on their capacity to resist innate immunity, and to survive and persist in an immunocompetent human host microbes have developed highly efficient and sophisticated complement evasion strategies.
Teresia Hallström +6 more
doaj +1 more source
Neisseria meningitidis Opc invasin binds to the sulphated tyrosines of activated vitronectin to attach to and invade human brain endothelial cells. [PDF]
PLoS Pathogens, 2010 The host vasculature is believed to constitute the principal route of dissemination of Neisseria meningitidis (Nm) throughout the body, resulting in septicaemia and meningitis in susceptible humans. In vitro, the Nm outer membrane protein Opc can enhance
Claudia Sa E Cunha +2 more
doaj +1 more source
Vitronectin binding protein, BOM1093, confers serum resistance on Borrelia miyamotoi
Scientific Reports, 2021 Borrelia miyamotoi, a member of the tick-borne relapsing fever spirochetes, shows a serum-resistant phenotype in vitro. This ability of B. miyamotoi may contribute to bacterial evasion of the host innate immune system.
Kozue Sato +9 more
doaj +1 more source
Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin. [PDF]
PLoS ONE, 2014 Candida albicans is a major cause of invasive fungal infections worldwide. Upon infection and when in contact with human plasma as well as body fluids the fungus is challenged by the activated complement system a central part of the human innate immune ...
Crisanto M Lopez +4 more
doaj +1 more source
Gastroenterology Insights, 2022 Background: hepatitis C is an inflammatory liver disease caused by the hepatitis C infection (HCV), and without treatment, almost 50% will progress to liver cirrhosis.
Salem Youssef Mohamed +3 more
doaj +1 more source
Frontiers in Microbiology, 2018 Pathogens causing pneumonia utilize the complement regulator vitronectin to evade complement-mediated killing. Although vitronectin is associated with several chronic lung diseases, the role of bronchoalveolar vitronectin in pneumonia has not been ...
Magnus Paulsson +10 more
doaj +1 more source
Functional role of vitronectin in breast cancer.
PLoS ONE, 2020 Breast Cancer is the most common form of cancer in women worldwide, impacting nearly 2.1 million women each year. Identification of new biomarkers could be key for early diagnosis and detection.
Alakesh Bera +10 more
doaj +1 more source