Results 21 to 30 of about 20,449 (205)

Neurite Growth and Polarization on Vitronectin Substrate after in Vitro Trauma is not Enhanced after IGF Treatment

Brain Sciences, 2018
Following traumatic brain injuries (TBI), insulin-like growth factor (IGF) is cortically widely upregulated. This upregulation has a potential role in the recovery of neuronal tissue, plasticity, and neurotrophic activity, though the molecular mechanisms
K. Bergen, M. Frödin, C. von Gertten, A. -C. Sandberg-Nordqvist, M. K. Sköld   +4 more
doaj   +1 more source

Plasminogen influence on the PAI-1 release by human platelets [PDF]

The Ukrainian Biochemical Journal
РАІ-1 (plasminogen activator inhibitor type 1), as a major physiological inhibitor of tissue plasminogen activator and urokinase, plays a key role in the regulation of fibrinolysis in vivo.
O. I. Yusova , T. V. Grinenko, T. F. Drobot’ko , A. O. Tykhomyrov   +3 more
doaj   +1 more source

Vitronectin and Its Interaction with PAI-1 Suggests a Functional Link to Vascular Changes in AMD Pathobiology

Cells, 2022
The pathogenesis of age-related macular degeneration (AMD), a frequent disorder of the central retina, is incompletely understood. Genome-wide association studies (GWAS) suggest a strong contribution of genomic variation in AMD susceptibility ...
Fabiola Biasella, Tobias Strunz, Christina Kiel, on behalf of the International AMD Genomics Consortium (IAMDGC), Bernhard H. F. Weber, Ulrike Friedrich   +5 more
doaj   +1 more source

Candida albicans and Candida glabrata triosephosphate isomerase – a moonlighting protein that can be exposed on the candidal cell surface and bind to human extracellular matrix proteins

BMC Microbiology, 2021
Background Triosephosphate isomerase (Tpi1) is a glycolytic enzyme that has recently been reported also to be an atypical proteinaceous component of the Candida yeast cell wall.
Dorota Satala, Grzegorz Satala, Marcin Zawrotniak, Andrzej Kozik   +3 more
doaj   +1 more source

Proteomic Analysis of Dendritic Filopodia-Rich Fraction Isolated by Telencephalin and Vitronectin Interaction

Frontiers in Synaptic Neuroscience, 2018
Dendritic filopodia are thin, long, and highly mobile protrusions functioning as spine precursors. By contrast with a wealth of knowledge on molecular profiles in spines, little is known about structural and functional proteins present in dendritic ...
Yutaka Furutani, Yoshihiro Yoshihara, Yoshihiro Yoshihara   +2 more
doaj   +1 more source

Vitronectin-based hydrogels recapitulate neuroblastoma growth conditions

Frontiers in Cell and Developmental Biology, 2022
The tumor microenvironment plays an important role in cancer development and the use of 3D in vitro systems that decouple different elements of this microenvironment is critical for the study of cancer progression. In neuroblastoma (NB), vitronectin (VN),
Ezequiel Monferrer, Ezequiel Monferrer, Oana Dobre, Sara Trujillo, Mariana Azevedo González Oliva, Alexandre Trubert-Paneli, Delia Acevedo-León, Rosa Noguera, Rosa Noguera, Manuel Salmeron-Sanchez   +9 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A C-type lectin from Bothrops jararacussu venom can adhere to extracellular matrix proteins and induce the rolling of leukocytes

Journal of Venomous Animals and Toxins including Tropical Diseases, 2007
Purification of a lectin from Bothrops jararacussu venom (BjcuL) was carried out using agarose-D-galactose affinity gel. MALDI-TOF gave a major signal at m/z 32028, suggesting the presence of a dimmer composed of two identical subunits.
S. L. Elífio-Esposito, P. L. Hess, A. N. Moreno, M. Lopes-Ferreira, C. A. O. Ricart, M. V. Souza, F. Hasselman-Zielinski, J. A. Becker, L. F. Pereira   +8 more
doaj   +1 more source

A Novel Vitronectin Peptide Facilitates Differentiation of Oligodendrocytes from Human Pluripotent Stem Cells (Synthetic ECM for Oligodendrocyte Differentiation)

Biology, 2021
Differentiation of oligodendrocytes (ODs) presents a challenge in regenerative medicine due to their role in various neurological diseases associated with dysmyelination and demyelination.
Won Ung Park, Gyu-Bum Yeon, Myeong-Sang Yu, Hui-Gwan Goo, Su-Hee Hwang, Dokyun Na, Dae-Sung Kim   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source