Results 11 to 20 of about 20,449 (205)

Improvement of human embryonic stem cell-derived retinal pigment epithelium cell adhesion, maturation, and function through coating with truncated recombinant human vitronectin [PDF]

International Journal of Ophthalmology, 2021
AIM: To explore an xeno-free and defined coating substrate suitable for the culture of H9 human embryonic stem cell-derived retinal pigment epithelial (hES-RPE) cells in vitro, and compare the behaviors and functions of hES-RPE cells on two culture ...
Xin-Yue Zhu, Yu-Hong Chen, Ting Zhang, Su-Jun Liu, Xin-Yue Bai, Xian-Yu Huang, Mei Jiang, Xiao-Dong Sun   +7 more
doaj   +1 more source

Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma

BMC Cancer, 2019
Background Vitronectin is a multifunctional glycoprotein known in several human tumors for its adhesive role in processes such as cell growth, angiogenesis and metastasis.
Rebeca Burgos-Panadero, Inmaculada Noguera, Adela Cañete, Samuel Navarro, Rosa Noguera   +4 more
doaj   +1 more source

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin

Molecular Neurodegeneration, 2008
Background The multifunctional protein vitronectin is present within the deposits associated with Alzheimer disease (AD), age-related macular degeneration (AMD), atherosclerosis, systemic amyloidoses, and glomerulonephritis.
Langen Ralf, Glabe Charles G, Kayed Rakez, Hsieh Chia-Ling, Isas J Mario, Shin Thuzar M, Chen Jeannie   +6 more
doaj   +1 more source

Outer membrane protein OMP76 of Riemerella anatipestifer contributes to complement evasion and virulence by binding to duck complement factor vitronectin

Virulence, 2023
Riemerella anatipestifer is an important bacterial pathogen in poultry. Pathogenic bacteria recruit host complement factors to resist the bactericidal effect of serum complement.
Sen Li, Yanhua Wang, Rongkun Yang, Xiaotong Zhu, Hongying Bai, Xiaojian Deng, Jiao Bai, Yang Zhang, Yuncai Xiao, Zili Li, Zhengfei Liu, Zutao Zhou   +11 more
doaj   +1 more source

Vitronectin—Master controller or micromanager? [PDF]

IUBMB Life, 2013
AbstractThe concept that the mammalian glycoprotein vitronectin acts as a biological ‘glue’ and key controller of mammalian tissue repair and remodelling activity is emerging from nearly 50 years of experimental in vitro and in vivo data. Unexpectedly, the vitronectin‐knockout (VN‐KO) mouse was found to be viable and to have largely normal phenotype ...
Leavesley, David, Kashyap, Abhishek, Croll, Tristan, Sivaramakrishnan, Manas, Shokoohmand, Ali, Hollier, Brett, Upton, Zee   +6 more
openaire   +5 more sources

Extracellular Matrix Proteins Confer Cell Adhesion-Mediated Drug Resistance Through Integrin αv in Glioblastoma Cells

Frontiers in Cell and Developmental Biology, 2021
Chemotherapy resistance to glioblastoma (GBM) remains an obstacle that is difficult to overcome, leading to poor prognosis of GBM patients. Many previous studies have focused on resistance mechanisms intrinsic to cancer cells; the microenvironment ...
Qi Yu, Qi Yu, Weikun Xiao, Songping Sun, Alireza Sohrabi, Jesse Liang, Stephanie K. Seidlits, Stephanie K. Seidlits, Stephanie K. Seidlits, Stephanie K. Seidlits   +9 more
doaj   +1 more source

Fluid Shear Stress and Fibroblast Growth Factor-2 Increase Endothelial Cell-Associated Vitronectin

Applied Bionics and Biomechanics, 2017
Vitronectin is a matricellular protein that plays an important role in both coagulation and angiogenesis through its effects on cell adhesion and the plasminogen system. Vitronectin is known to bind to endothelial cells upon integrin activation. However,
Justin G. Mathew, Sarah Basehore, Alisa Morss Clyne   +2 more
doaj   +1 more source

Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins

Journal of Neuroinflammation, 2011
Background As the primary resident immune cells, microglia play a central role in regulating inflammatory processes in the CNS. The extracellular matrix (ECM) protein vitronectin promotes microglial activation, switching microglia into an activated ...
Welser-Alves Jennifer V, Boroujerdi Amin, Tigges Ulrich, Milner Richard   +3 more
doaj   +1 more source

Liver vitronectin release into the bloodstream increases due to reduced vagal muscarinic signaling after cerebral stroke in female mice

Physiological Reports, 2022
Vitronectin (VTN) is a glycoprotein enriched in the blood and activates integrin receptors. VTN blood levels increase only in female mice 24 h after an ischemic stroke and exacerbate brain injury through IL‐6‐driven inflammation, but the VTN induction ...
Matthew P. Keasey, Chiharu Lovins, Cuihong Jia, Theo Hagg   +3 more
doaj   +1 more source

Vitronectin Levels in Leukocyte-platelet Rich Fibrin, Injectable-platelet Rich Fibrin, and Serum: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Platelet-rich Fibrin (PRF) is an autologous platelet concentrate preparation containing several proteins that aid in healing. Vitronectin is one of these proteins that has not been quantified in all types of PRF. Various protocols have been
Anirudh B Acharya, Aditi Lokhande, Swetha Acharya, Mihir Kulkarni, Srinath Thakur   +4 more
doaj   +1 more source