Associations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women [PDF]
, 1999 Obesity, the insulin resistance syndrome, and atherosclerosis are closely linked and may all be determinants of an increased acute-phase response.
Bots, M.L. (Michiel) +7 more
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Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms
Gut and Liver, 2013 Background/AimsPlasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas.Methods : We reviewed the medical ...
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Review: Therapeutic potential of plasminogen activator inhibitor-1 inhibitors
Therapeutic Advances in Cardiovascular Disease, 2010 Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of fibrinolysis and regulates cell migration and fibrosis. Preclinical studies using genetically altered mice and biological or small molecule inhibitors have elucidated a role for PAI-1 in the pathogenesis of thrombosis, vascular remodeling, renal injury, and initiation of
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Plasminogen Activator Inhibitor-1 Levels and Polymorphisms
Archives of Pathology & Laboratory Medicine, 2002 Abstract Objective.—To review the published evidence of a relationship between levels of plasminogen activator inhibitor-1 (PAI-1) or the 4G/5G polymorphism of the PAI-1 gene and the occurrence of venous thromboembolic disease. Methods.—Review of the medical literature using computerized databases and a review of secondary
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Tissue plasminogen activator and plasminogen activator inhibitor-1 in human choledochal bile
Yonsei Medical Journal, 2000 Fibrinolytic properties have been detected in animal and human gallbladder (GB) bile. Plasminogen activator inhibitor-1 (PAI-1) has been reported in greater concentration in GB stone bile and may be a nucleating factor in the pathogenesis of GB stone formation. It is unknown whether or not human choledochal bile has similar properties, which could have
S J, Lee +11 more
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Cancer Biology & Medicine, 2009 OBJECTIVE To investigate the expression of urokinase-type plasminogen (uPA), its inhibitor-1 (PAI-1) mRNA and its protein in human gastric cancer and to fi nd out the relationship among the tumor differentiation, angiogenesis, and other clinical ...
Jifeng WU, Xia SHENG, Rong QIN, Hong ZHANG
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Retraction: The effects of residual platelets in plasma on plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays. [PDF]
PLoS ONE, 2018 PLOS ONE Editors
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Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. [PDF]
, 2015 In glioblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive phenotype. EGFR may be targeted therapeutically; however, resistance to EGFR-targeting drugs such as Erlotinib and Gefitinib develops quickly.
Cavenee, WK +5 more
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Metabolic syndrome, plasminogen activator inhibitor (pai-1) and atherosclerosis
Zdravniški Vestnik, 2005 Background: Metabolic syndrome is associated with high cardiovascular morbidity and mortality and its increasing prevalence is becoming one of the major health problems.
Alenka Mavri
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Medical Journal of BabylonBackground: Worldwide, the occurrence of breast cancer is elevated as well as the number of mortality in women cancers. The movement of cancer cells from the first stage and invasion of the surrounding tissue are called cancer metastasis.
Sheerin H. Abbas +2 more
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