Results 1 to 10 of about 7,182,421 (220)

Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19 [PDF]

Frontiers in Immunology, 2023
Patients with coronavirus disease-2019 (COVID-19) have an increased risk of thrombosis and acute respiratory distress syndrome (ARDS). Thrombosis is often attributed to increases in plasminogen activator inhibitor-1 (PAI-1) and a shut-down of ...
Tetiana Yatsenko, Tetiana Yatsenko, Ricardo Rios, Tatiane Nogueira, Yousef Salama, Satoshi Takahashi, Yoko Tabe, Toshio Naito, Kazuhisa Takahashi, Kazuhisa Takahashi, Koichi Hattori, Koichi Hattori, Beate Heissig   +12 more
doaj   +2 more sources

Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice [PDF]

Scientific Reports, 2023
Although several angiogenesis-related factors are reportedly involved in the pathogenesis of ulcerative colitis (UC), the mechanisms by which they contribute to disease are unclear.
Yoshifumi Kida, Toshiya Okahisa, Yasushi Sato, Masahiro Bando, Shota Fujimoto, Beibei Ma, Tadahiko Nakagawa, Tomoyuki Kawaguchi, Fumika Nakamura, Koichi Okamoto, Hiroshi Miyamoto, Masahiro Sogabe, Koichi Tsuneyama, Tetsuji Takayama   +13 more
doaj   +2 more sources

A “turn-off” photoacoustic contrast for urokinase-type plasminogen activator activity [PDF]

npj Biomedical Innovations
The ability to distinguish cancerous lesions based on aggressiveness using noninvasive molecular imaging techniques enables more precise and accurate diagnosis.
Ananya Sharma, Suvam Kumar Panda, Thuria Hasan, Sneha Ravanan, Sanhita Sinharay   +4 more
doaj   +2 more sources

Urokinase-type plasminogen activator receptor as a predictive marker for cardiac disease among type 2 diabetic patients

Medical Journal of Babylon, 2023
Background: Type 2 diabetes mellitus is a progressive and chronic disease manifested by β-cell dysfunction and improved insulin resistance. Higher levels of urokinase-type plasminogen activator receptors have been found to predict morbidity and mortality
Melak Saleh Mohammed, Hind Shakir Ahmed
doaj   +1 more source

The uPA System Differentially Alters Fibroblast Fate and Profibrotic Ability in Skin Fibrosis

Frontiers in Immunology, 2022
Skin fibrosis is a common pathological feature of various diseases, and few treatment strategies are available because of the molecular pathogenesis is poorly understood.
Ming-Li Zou, Ming-Li Zou, Ying-Ying Teng, Zhong-hua Chen, Si-Yu Liu, Yuan Jia, Kai-Wen Zhang, Jun-Jie Wu, Zheng-Dong Yuan, Xiao-Yu Tang, Shun Yu, Jun-Xing Ye, Xia Li, Xiao-Jin Zhou, Feng-Lai Yuan, Feng-Lai Yuan   +15 more
doaj   +1 more source

Values of serum PCT, suPAR combined with severity scores for evaluating prognosis of septic shock patients

Romanian Journal of Laboratory Medicine, 2021
Background: To explore the values of serum procalcitonin (PCT), soluble urokinase-type plasminogen activator receptor (suPAR) combined with APACHE II and SOFA scores for evaluating the prognosis of septic shock patients.
Wang Wenxin, Jie Yingxin, Zhou Jia
doaj   +1 more source

Corrigendum: Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19 [PDF]

Frontiers in Immunology
Tetiana Yatsenko, Tetiana Yatsenko, Ricardo Rios, Tatiane Nogueira, Yousef Salama, Satoshi Takahashi, Yoko Tabe, Toshio Naito, Kazuhisa Takahashi, Kazuhisa Takahashi, Koichi Hattori, Koichi Hattori, Beate Heissig   +12 more
doaj   +2 more sources

Crystal structure and cellular functions of uPAR dimer

Nature Communications, 2022
The structural basis for urokinase-type plasminogen activator receptor (uPAR) dimerization is not understood. Here, the authors solve the crystal structure of soluble uPAR dimers, identifying substantial structural changes compared to the monomer.
Shujuan Yu, Yaqun Sui, Jiawei Wang, Yongdong Li, Hanlin Li, Yingping Cao, Liqing Chen, Longguang Jiang, Cai Yuan, Mingdong Huang   +9 more
doaj   +1 more source

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

Düzce Tıp Fakültesi Dergisi, 2021
Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types.
Mahmut Şenyurt, Engin Şebin, Sibel İba Yılmaz, Ali Batur, Orhan Delice, Omer Karasahin, Kadir Küçükceran   +6 more
doaj   +1 more source

Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage

Brain Hemorrhages, 2020
Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center study.
Zhe Kang Law, Michael Desborough, Kamini Rakkar, Philip M. Bath, Ulvi Bayraktutan, Nikola Sprigg   +5 more
doaj   +1 more source