Amiloride selectively inhibits the urokinase‐type plasminogen activator [PDF]
FEBS Letters, 1987 The diuretic drug amiloride, an inhibitor of Na+ uptake, competitively inhibits the catalytic activity of the urokinase‐type plasminogen activator (u‐PA), with a K i of 7 × 10−6 M. Generation of plasmin, cleavage of peptide substrates, and interaction of u‐PA with a specific macromolecular proteinase inhibitor are all prevented in the presence of the ...
J D Vassalli, D Belin
exaly +5 more sources
Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19 [PDF]
Frontiers in Immunology, 2023 Patients with coronavirus disease-2019 (COVID-19) have an increased risk of thrombosis and acute respiratory distress syndrome (ARDS). Thrombosis is often attributed to increases in plasminogen activator inhibitor-1 (PAI-1) and a shut-down of ...
Tetiana Yatsenko +12 more
doaj +2 more sources
Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice [PDF]
Scientific Reports, 2023 Although several angiogenesis-related factors are reportedly involved in the pathogenesis of ulcerative colitis (UC), the mechanisms by which they contribute to disease are unclear.
Yoshifumi Kida +13 more
doaj +2 more sources
A “turn-off” photoacoustic contrast for urokinase-type plasminogen activator activity [PDF]
npj Biomedical InnovationsThe ability to distinguish cancerous lesions based on aggressiveness using noninvasive molecular imaging techniques enables more precise and accurate diagnosis.
Ananya Sharma +4 more
doaj +2 more sources
Radiology and Oncology, 2015 Background. Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) play a key role in tumour invasion and metastasis. High levels of both proteolytic enzymes are associated with poor prognosis in breast cancer patients ...
Lampelj Maja +8 more
doaj +2 more sources
Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b. [PDF]
PLoS ONE, 2012 Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Tina K Koch +7 more
doaj +2 more sources
Urokinase-Type Plasminogen Activator Receptor (uPAR) in Inflammation and Disease: A Unique Inflammatory Pathway Activator [PDF]
BiomedicinesThe urokinase-type plasminogen activator receptor (uPAR) is a unique protease binding receptor, now recognized as a key regulator of inflammation.
Mostafa Hamada +9 more
doaj +2 more sources
The study of molecular markers for the progression of Barrett's Oesophagus to adenocarcinoma to identify markers that can be used as diagnostic tools. [PDF]
, 2002 Barrett's oesophagus is a complication of gastro-oesophageal reflux disease and is the single most important predisposing factor for the development of adenocarcinoma of the oesophagus.
Cadd, Verity Anne
core +7 more sources
Medical Journal of Babylon, 2023 Background: Type 2 diabetes mellitus is a progressive and chronic disease manifested by β-cell dysfunction and improved insulin resistance. Higher levels of urokinase-type plasminogen activator receptors have been found to predict morbidity and mortality
Melak Saleh Mohammed, Hind Shakir Ahmed
doaj +1 more source
Corrigendum: Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19 [PDF]
Frontiers in ImmunologyTetiana Yatsenko +12 more
doaj +2 more sources