Results 1 to 10 of about 729,299 (226)

Inhibiting the uPAR/FPR1 interactions reduces blood-retinal barrier breakdown and improves retinal function in a rat model of diabetes [PDF]

Frontiers in Neuroscience
Diabetic retinopathy (DR) is a leading cause of blindness characterized by early neurovascular damage driven by hyperglycemia-induced mechanisms, including inflammation.
Alessio Canovai, Rosario Amato, Alberto Melecchi, Maria De Fenza, Vincenzo Pavone, Daniele D’Alonzo, Maurizio Cammalleri, Massimo Dal Monte, Massimo Dal Monte   +8 more
doaj   +2 more sources

Urokinase-type plasminogen activator receptor as a predictive marker for cardiac disease among type 2 diabetic patients

Medical Journal of Babylon, 2023
Background: Type 2 diabetes mellitus is a progressive and chronic disease manifested by β-cell dysfunction and improved insulin resistance. Higher levels of urokinase-type plasminogen activator receptors have been found to predict morbidity and mortality
Melak Saleh Mohammed, Hind Shakir Ahmed
doaj   +1 more source

UPAR Overexpression Could Be a Potential Favorable Prognostic Marker in Invasive Ductal Carcinoma of Breast

Acta Medica Iranica, 2022
Breast cancer is the most common malignant tumor in women. Some factors, including histological grade, vascular invasion, and metastasis, are known prognostic factors.
Ata Abbasi, Elnaz Mehdipour, Hengameh Mojdeganlou   +2 more
doaj   +1 more source

The Urokinase Plasminogen Activation System in Pancreatic Cancer: Prospective Diagnostic and Therapeutic Targets

Biomolecules, 2022
Pancreatic cancer is a highly aggressive malignancy that features high recurrence rates and the poorest prognosis of all solid cancers. The urokinase plasminogen activation system (uPAS) is strongly implicated in the pathophysiology and clinical outcomes
Ashna A. Kumar, Benjamin J. Buckley, Marie Ranson   +2 more
doaj   +1 more source

Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors

Frontiers in Pharmacology, 2021
Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the ...
María D. Valls, María Soldado, Jorge Arasa, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, Bruce N. Cronstein, Bruce N. Cronstein, M. Antonia Noguera, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Terencio, M. Carmen Montesinos, M. Carmen Montesinos   +14 more
doaj   +1 more source

Integrin, Exosome and Kidney Disease

Frontiers in Physiology, 2021
Integrins are transmembrane receptors that function as noncovalent heterodimers that mediate cellular adhesion and migration, cell to cell communication, and intracellular signaling activation.
An-Ran Shen, Xin Zhong, Tao-Tao Tang, Cui Wang, Jing Jing, Bi-Cheng Liu, Lin-Li Lv   +6 more
doaj   +1 more source

Detection of soluble urokinase type plasminogen activator receptors in children with gingivitis and normal subjects

BMC Oral Health, 2022
Background Gingivitis is a reversible condition; however, if left untreated, it progresses to periodontitis, which a serious infection that leads to bone destruction.
Mohamed Abd‑Ellatif El‑Patal, Mona A. Khalil, Walaa Shipl, Ibrahim Barakat, Eman M. I. Youssef, Shahinaz El Attar, Adel Fathi, Alaa A. Abdallah   +7 more
doaj   +1 more source

Modulation of Cellular Function by the Urokinase Receptor Signalling: A Mechanistic View

Frontiers in Cell and Developmental Biology, 2022
Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease urokinase (uPA), converting plasminogen into plasmin, a broad spectrum ...
Daniela Alfano, Paola Franco, Maria Patrizia Stoppelli   +2 more
doaj   +1 more source

Function of hepatocyte growth factor in gastric cancer proliferation and invasion [PDF]

Yeungnam University Journal of Medicine, 2020
Cancer incidence has been increasing steadily and is the leading cause of mortality worldwide. Gastric cancer is still most common malignancy in Korea. Cancer initiation and progression are multistep processes involving various growth factors and their ...
Sung Ae Koh, Kyung Hee Lee
doaj   +1 more source

In vitro identification of novel plasminogen-binding receptors of the pathogen Leptospira interrogans. [PDF]

PLoS ONE, 2010
BACKGROUND: Leptospirosis is a multisystem disease caused by pathogenic strains of the genus Leptospira. We have reported that Leptospira are able to bind plasminogen (PLG), to generate active plasmin in the presence of activator, and to degrade purified
Monica L Vieira, Marina V Atzingen, Tatiane R Oliveira, Rosane Oliveira, Daniel M Andrade, Silvio A Vasconcellos, Ana L T O Nascimento   +6 more
doaj   +1 more source