Results 1 to 10 of about 676,629 (244)

In vitro identification of novel plasminogen-binding receptors of the pathogen Leptospira interrogans. [PDF]

PLoS ONE, 2010
BACKGROUND: Leptospirosis is a multisystem disease caused by pathogenic strains of the genus Leptospira. We have reported that Leptospira are able to bind plasminogen (PLG), to generate active plasmin in the presence of activator, and to degrade purified
Monica L Vieira, Marina V Atzingen, Tatiane R Oliveira, Rosane Oliveira, Daniel M Andrade, Silvio A Vasconcellos, Ana L T O Nascimento   +6 more
doaj   +1 more source

In Vitro Study of the Fibrinolytic Activity via Single Chain Urokinase-Type Plasminogen Activator and Molecular Docking of FGFC1

Molecules, 2021
Fungi fibrinolytic compound 1 (FGFC1) is a rare marine-derived compound that can enhance fibrinolysis both in vitro and in vivo. The fibrinolytic activity characterization of FGFC1 mediated by plasminogen (Glu-/Lys-) and a single-chain urokinase-type ...
Chunli Gao, Quan Shen, Pengjie Tang, Yuling Cao, Houwen Lin, Bailin Li, Peng Sun, Bin Bao, Wenhui Wu   +8 more
doaj   +1 more source

Determining biomarkers for evaluation and diagnosis of hereditary angioedema

Clinical and Translational Allergy, 2022
Rationale Kallikrein‐bradykinin‐forming cascade is known to cause hereditary angioedema (HAE) acute angioedema (AE) attacks. Further research of HAE attacks is needed to explain disease heterogeneity, predict treatment response and identify biomarkers ...
Umesh Singh, Jonathan A. Bernstein
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

A study of the interaction between Helicobacter pylori and components of the human fibrinolytic system

Brazilian Journal of Medical and Biological Research, 2000
The interaction of plasminogen, tissue plasminogen activator (t-PA) and urokinase with a clinical strain of Helicobacter pylori was studied. Plasminogen bound to the surface of H. pylori cells in a concentration-dependent manner and could be activated to
A. Yarzábal, L. Avilán, K. Hoelzl, M. de Muñoz, J. Puig, I. Kansau   +5 more
doaj   +1 more source

Soluble urokinase plasminogen activator receptor: a novel biomarker of pediatric community-acquired and hospitalacquired pneumonia

The Turkish Journal of Pediatrics, 2022
Background. Soluble urokinase plasminogen activator receptor (suPAR) is an emerging biomarker in different clinical disorders but data in pediatric pneumonia is scarce.
Muhammad Said El-Mekkawy, Shimaa El-Shafey Soliman, Nagwan Yossery Saleh   +2 more
doaj   +1 more source

suPAR na avaliação do prognóstico após permanência na unidade de terapia intensiva: um estudo piloto

Revista Brasileira de Terapia Intensiva, 2019
RESUMO Objetivo: Determinar o desempenho da dosagem do receptor ativador de plasminogênio tipo uroquinase solúvel quando da alta da unidade de terapia intensiva para predição da mortalidade após permanência na mesma unidade.
Joana Silvestre, Luis Coelho, João Gonçalves Pereira, Vitor Mendes, Camila Tapadinhas, Pedro Póvoa   +5 more
doaj   +1 more source

Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors. [PDF]

PLoS ONE, 2014
Aerolysin is a secreted bacterial toxin that perforates the plasma membrane of a target cell with lethal consequences. Previously explored native and epitope-tagged forms of the toxin do not allow site-specific modification of the mature toxin with a ...
Irene Wuethrich, Janneke G C Peeters, Annet E M Blom, Christopher S Theile, Zeyang Li, Eric Spooner, Hidde L Ploegh, Carla P Guimaraes   +7 more
doaj   +1 more source

Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasiveness

Molecular Cancer, 2009
Background Generation of plasmin is a characteristic of tumor cells, promoting the degradation of extracellular matrix, tumor progression and metastasis.
Doljak Bojan, Obermajer Nataša, Kos Janko   +2 more
doaj   +1 more source

Single amino acid substitutions in the chemotactic sequence of urokinase receptor modulate cell migration and invasion. [PDF]

PLoS ONE, 2012
The receptor for urokinase-type plasminogen activator (uPAR) plays an important role in controlling cell migration. uPAR binds urokinase and vitronectin extracellular ligands, and signals in complex with transmembrane receptors such as Formyl-peptide ...
Katia Bifulco, Immacolata Longanesi-Cattani, Paola Franco, Vincenzo Pavone, Pietro Mugione, Gioconda Di Carluccio, Maria Teresa Masucci, Claudio Arra, Giuseppe Pirozzi, Maria Patrizia Stoppelli, Maria Vincenza Carriero   +10 more
doaj   +1 more source