Results 1 to 10 of about 14,579 (261)

FPR1 co-localizes with uPAR on the surface of uPAR-expressing HEK-293 cells.

, 2014
HEK-293 cells stably transfected with uPAR cDNA (uPAR-293 cells) were seeded on glass coverslips and transiently transfected with FPR1 cDNA. After 24 h, cells were incubated for further 24 h in culture medium (DMEM) containing 10% serum (Basal) or in ...
Nunzia Montuori (511913), Giuseppina Amodio (511911), Pia Ragno (342854), Paolo Remondelli (511912), Anna Li Santi (511910), Daniela Alfano (342853), Anna Gorrasi (511909)   +6 more
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uPAR immunohistochemistry in urothelial neoplasia of the bladder.

, 2015
The figure shows examples of different uPAR scores at the invasive front of the tumour: uPAR score = 0 (no uPAR positive cells detected), uPAR score = 3 (between 5% and 10% positive cells), and uPAR score = 6 (>70% positively stained cells).
Peter Thind (785525), Gunilla Høyer-Hansen (361869), Ole Didrik Laerum (785528), Benedikte Richter Iversen (785523), Martin Illemann (785524), Helle Pappot (785522), Hans von der Maase (785527), Lisbeth Salling (785526), Ib Jarle Christensen (399757), Line Hammer Dohn (785521)   +9 more
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Kaplan-Meier overall survival analyses for uPAR^E (a and b), uPAR^S (c) and uPAR^PT (d) in rectal cancer.

, 2015
In stage B patients, (a): overall survival was significantly reduced with uPARE positive in central region of tumour (n = 125) and (b): with strong uPARE in invasive front of tumours (n = 168).
Julie Fletcher (562693), Seong Beom Ahn (562691), Mark S. Baker (562698), Sun Young Kwun (562694), Charles Chan (9232), Candice Clarke (562695), Abidali Mohamedali (562692), Pierre H. Chapuis (562697), Owen F. Dent (562696), Edouard C. Nice (233922)   +9 more
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Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma.

PLoS ONE, 2012
BackgroundMedulloblastoma is a highly invasive cancer of central nervous system diagnosed mainly in children. Matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator receptor (uPAR) are over expressed in several cancers and well ...
Ramaprasada Rao Kotipatruni, Arun Kumar Nalla, Swapna Asuthkar, Christopher S Gondi, Dzung H Dinh, Jasti S Rao   +5 more
doaj   +1 more source

Urokinase-type plasminogen activator receptor combined with modified Alvarado scoring system and C-reactive protein for diagnosis of acute appendicitis in children

Di-san junyi daxue xuebao, 2020
Objective To investigate the serum level of urokinase-type plasminogen activator receptor (uPAR) in children with acute appendicitis and assess the diagnostic value of uPAR combined with C-reactive protein (CRP) and modified Alvarado score for acute ...
SUN Chuanwei, LI Aijun, SUN Hong, ZHANG Wei, WANG Guibo, LEI Jie, YANG Zhonggang   +6 more
doaj   +1 more source

uPAR is constitutively internalized in the absence of ligands.

, 2013
In all cases, the images presented are representative of 3–5 independent experiments. Panel A shows a biotinylation assay performed in HT1080 cells.
Francesco Blasi (61418), Carlo Tacchetti (252415), Katia Cortese (166183), Macarena Sahores (375932), Chris D. Madsen (375934)   +4 more
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Spontaneous ‘uPAR-rich’ cell selection in the monolayer by a uPAR-plasmin-TGFβ1 positive feedback loop.

, 2018
All cells in the model (A) express the same level of uPAR (the uPAR concentration in the cells is indicated by the red color) at initialization of a simulation.
Joao Carvalho (5487974), Marloes van den Broek (5487980), Sonja E. M. Boas (5487977), Marie-José Goumans (516094), Pieter Koolwijk (284312), Ester M. Weijers (755095), Roeland M. H. Merks (53978)   +6 more
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Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
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uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder--Possible Clinical Implications.

PLoS ONE, 2015
The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder.
Line Hammer Dohn, Helle Pappot, Benedikte Richter Iversen, Martin Illemann, Gunilla Høyer-Hansen, Ib Jarle Christensen, Peter Thind, Lisbeth Salling, Hans von der Maase, Ole Didrik Laerum   +9 more
doaj   +1 more source

uPAR carrying S90E and S90P substitutions. A

, 2012
: Arg91 and Tyr92 superposition of the backbone atoms of the various 88–92 segments of SuPAR from x-ray structures. Residue 89 is not visible in the electron density map of 1YWH. Side chains are reported as stick, Arg residues are in blue.
Katia Bifulco (133627), Vincenzo Pavone (133641), Giuseppe Pirozzi (133651), Paola Franco (133638), Claudio Arra (133331), Maria Teresa Masucci (133648), Maria Vincenza Carriero (133657), Immacolata Longanesi-Cattani (133632), Pietro Mugione (133644), Maria Patrizia Stoppelli (133653), Gioconda Di Carluccio (133646)   +10 more
core   +1 more source