New Pieces in the Puzzle of uPAR Role in Cell Migration Mechanisms
Cells, 2020 The urokinase (uPA) receptor (uPAR) plays a key role in cell migration. We previously showed that uPAR-negative HEK-293 cells efficiently migrate toward serum but, after uPAR ectopic expression, migrate only in a uPAR-dependent manner. In fact, migration
Nunzia Montuori +2 more
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Frontiers in Cell and Developmental Biology, 2021 The interaction between the serine protease urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) focalizes plasminogen activation to cell surfaces, thereby regulating extravascular fibrinolysis, cell adhesion, and ...
Michael Ploug
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The urokinase receptor takes control of cell migration by recruiting integrins and FPR1 on the cell surface. [PDF]
PLoS ONE, 2014 The receptor (uPAR) of the urokinase-type plasminogen activator (uPA) is crucial in cell migration since it concentrates uPA proteolytic activity at the cell surface, binds vitronectin and associates to integrins.
Anna Gorrasi +6 more
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Research Progress of Targeting uPA-uPAR System in Tumor Therapy
Zhongliu Fangzhi Yanjiu, 2023 The uPA-uPAR system is highly expressed in various tumor tissues. This system can promote the degradation of extracellular matrix proteins, as well as combine with vitronectin and integrin to transmit intracellular signal transduction.
CAI Weiwen +5 more
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Single amino acid substitutions in the chemotactic sequence of urokinase receptor modulate cell migration and invasion. [PDF]
PLoS ONE, 2012 The receptor for urokinase-type plasminogen activator (uPAR) plays an important role in controlling cell migration. uPAR binds urokinase and vitronectin extracellular ligands, and signals in complex with transmembrane receptors such as Formyl-peptide ...
Katia Bifulco +10 more
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Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes. [PDF]
PLoS ONE, 2014 The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front.
Synnøve Magnussen +9 more
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Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR-/-) Mice. [PDF]
PLoS ONE, 2015 Atherosclerosis, a chronic inflammatory disease, arises from metabolic disorders and is driven by inappropriate recruitment and proliferation of monocytes / macrophages and vascular smooth-muscle-cells.
Jan Larmann +8 more
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Clinical and Translational Allergy, 2023 Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown.
Michael A. Portelli +8 more
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Pharmaceuticals, 2023 During tumorigenesis, urokinase (uPA) and uPA receptor (uPAR) play essential roles in mediating pathological progression in many cancers. To understand the crosstalk between the uPA/uPAR signaling and cancer, as well as to decipher their cellular ...
Yu-Ching Chang +4 more
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TLR4 Response to LPS Is Reinforced by Urokinase Receptor
Frontiers in Immunology, 2020 GPI-anchored uPAR is the receptor for the extracellular serine protease urokinase-type plasminogen activator (uPA). Though uPAR role in inflammatory processes is documented, underlying mechanisms are not fully understood.
Yulia Kiyan +8 more
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