Differential Roles of uPAR in Peritoneal Ovarian Carcinomatosis [PDF]
Neoplasia: An International Journal for Oncology Research, 2012 Epithelial ovarian cancer is the fourth leading cause of death from gynecologic malignancies in the United States. Most cases are diagnosed at late stages, with the solid tumor masses growing as peritoneal implants, or floating within the ascitic fluid ...
Nada N. Al-Hassan +6 more
doaj +4 more sources
RhoB regulates uPAR signalling [PDF]
Journal of Cell Science, 2012 uPA and its receptor, uPAR, play important roles in promoting cancer cell adhesion, migration and invasion. Rho GTPases are key coordinators of these processes; the Rho GTPase Rac1 has previously been implicated in uPA/uPAR-induced migratory or morphological cell responses.
Daniela Alfano +3 more
core +8 more sources
New Pieces in the Puzzle of uPAR Role in Cell Migration Mechanisms [PDF]
Cells, 2020 The urokinase (uPA) receptor (uPAR) plays a key role in cell migration. We previously showed that uPAR-negative HEK-293 cells efficiently migrate toward serum but, after uPAR ectopic expression, migrate only in a uPAR-dependent manner. In fact, migration
Anna Gorrasi +5 more
doaj +3 more sources
Research Progress of Targeting uPA-uPAR System in Tumor Therapy
Zhongliu Fangzhi Yanjiu, 2023 The uPA-uPAR system is highly expressed in various tumor tissues. This system can promote the degradation of extracellular matrix proteins, as well as combine with vitronectin and integrin to transmit intracellular signal transduction.
CAI Weiwen +5 more
doaj +1 more source
The urokinase receptor takes control of cell migration by recruiting integrins and FPR1 on the cell surface. [PDF]
PLoS ONE, 2014 The receptor (uPAR) of the urokinase-type plasminogen activator (uPA) is crucial in cell migration since it concentrates uPA proteolytic activity at the cell surface, binds vitronectin and associates to integrins.
Anna Gorrasi +6 more
doaj +1 more source
Single amino acid substitutions in the chemotactic sequence of urokinase receptor modulate cell migration and invasion. [PDF]
PLoS ONE, 2012 The receptor for urokinase-type plasminogen activator (uPAR) plays an important role in controlling cell migration. uPAR binds urokinase and vitronectin extracellular ligands, and signals in complex with transmembrane receptors such as Formyl-peptide ...
Katia Bifulco +10 more
doaj +1 more source
Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes. [PDF]
PLoS ONE, 2014 The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front.
Synnøve Magnussen +9 more
doaj +1 more source
Cell Adhesion & Migration, 2013 Vascular endothelial growth factor (VEGF)-initiated angiogenesis requires both coordinated proteolytic degradation of extracellular matrix provided by the urokinase plasminogen activator/urokinase receptor (uPA/uPAR) system and regulation of cell-migration provided by integrin-matrix interaction.
Pavel, Uhrin, Johannes M, Breuss
openaire +2 more sources
uPAR: An Essential Factor for Tumor Development [PDF]
Journal of Cancer, 2021 Tumorigenesis is closely related to the loss of control of many genes. Urokinase-type plasminogen activator receptor (uPAR), a glycolipid-anchored protein on the cell surface, is controlled by many factors in tumorigenesis and is expressed in many tumor tissues.
Lv, Tao +8 more
openaire +2 more sources
Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR-/-) Mice. [PDF]
PLoS ONE, 2015 Atherosclerosis, a chronic inflammatory disease, arises from metabolic disorders and is driven by inappropriate recruitment and proliferation of monocytes / macrophages and vascular smooth-muscle-cells.
Jan Larmann +8 more
doaj +1 more source