Results 31 to 40 of about 14,530 (214)

A doxycycline-inducible urokinase receptor (uPAR) upregulates uPAR activities including resistance to anoikis in human prostate cancer cell lines

Molecular Cancer, 2007
Background The urokinase receptor (uPAR) mediates a diverse array of cellular processes including several events involved in prostate cancer metastasis.
Reiser Jakob, Agha-Mohammadi Siamak, Kutner Robert, Hasanuzzaman Mohammad, Sehgal Inder   +4 more
doaj   +1 more source

uPAR Knockout Results in a Deep Glycolytic and OXPHOS Reprogramming in Melanoma and Colon Carcinoma Cell Lines

Cells, 2020
Urokinase Plasminogen Activator (uPA) Receptor (uPAR) is a well-known GPI-anchored three-domain membrane protein with pro-tumor roles largely shown in all the malignant tumors where it is over-expressed.
Alessio Biagioni, Anna Laurenzana, Anastasia Chillà, Mario Del Rosso, Elena Andreucci, Martina Poteti, Daniele Bani, Daniele Guasti, Gabriella Fibbi, Francesca Margheri   +9 more
doaj   +1 more source

Identification of uPAR-positive chemoresistant cells in small cell lung cancer. [PDF]

PLoS ONE, 2007
BACKGROUND: The urokinase plasminogen activator (uPA) and its receptor (uPAR/CD87) are major regulators of extracellular matrix degradation and are involved in cell migration and invasion under physiological and pathological conditions.
Margarita Gutova, Joseph Najbauer, Anna Gevorgyan, Marianne Z Metz, Yehua Weng, Chu-Chih Shih, Karen S Aboody   +6 more
doaj   +1 more source

Human antibody VH domains targeting uPAR as candidate therapeutics for cancers

Frontiers in Oncology, 2023
The high expression of uPAR has been linked to tumor progression, invasion, and metastasis in several types of cancer. Such overexpression of uPAR makes it a potential target for immunotherapies across common cancers such as breast, colorectal, lung ...
Xiaojie Chu, Wei Li, Margaret G. Hines, Ilya Lyakhov, John W. Mellors, John W. Mellors, Dimiter S. Dimitrov, Dimiter S. Dimitrov   +7 more
doaj   +1 more source

An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment

Cancer Biology & Medicine, 2020
Objective: In this study, we aimed to develop an amino-terminal fragment (ATF) peptide-targeted liposome carrying β-elemene (ATF24-PEG-Lipo-β-E) for targeted delivery into urokinase plasminogen activator receptor-overexpressing bladder cancer cells ...
Bingtao Zhai, Peng Chen, Wengang Wang, Shuiping Liu, Jiao Feng, Ting Duan, Yu Xiang, Ruonan Zhang, Mingming Zhang, Xuemeng Han, Xiaying Chen, Qiujie Li, Guohua Li, Ying Liu, Xingxing Huang, Wenzheng Zhang, Ting Pan, Lili Yan, Ting Jin, Tian Xie, Xinbing Sui   +20 more
doaj   +1 more source

The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophils. [PDF]

PLoS ONE, 2011
The urokinase-type plasminogen activator receptor (uPAR), a glycosylphosphatidylinositol (GPI) anchored membrane protein, regulates urokinase (uPA) protease activity, chemotaxis, cell-cell interactions, and phagocytosis of apoptotic cells.
Gang Liu, Yanping Yang, Shanzhong Yang, Sami Banerjee, Andressa De Freitas, Arnaud Friggeri, Kasey I Davis, Edward Abraham   +7 more
doaj   +1 more source

Activation of Urokinase Plasminogen Activator and Its Receptor Axis Is Essential for Macrophage Infiltration in a Prostate Cancer Mouse Model

Neoplasia: An International Journal for Oncology Research, 2011
Macrophages within the tumor microenvironment promote angiogenesis, extracellular matrix breakdown, and tumor cell migration, invasion, and metastasis. Activation of the urokinase plasminogen activator (uPA) and its receptor (uPAR) axis promotes prostate
Jian Zhang, Sudha Sud, Kosuke Mizutani, Margaret R. Gyetko, Kenneth J. Pienta   +4 more
doaj   +1 more source

The Association between Plasma Levels of Intact and Cleaved uPAR Levels and the Risk of Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer

Diagnostics, 2020
Radical prostatectomy (RP) is a curatively intended treatment option for clinically localized non-metastatic prostate cancer (PCa). Novel biomarkers could refine treatment choice based on a better identification of men at risk of biochemical recurrence ...
Hein Vincent Stroomberg, Gitte Kristensen, Kasper Drimer Berg, Solvej Lippert, Klaus Brasso, Martin Andreas Røder   +5 more
doaj   +1 more source

CYP1B1 induces tumorigenic metastasis through promotion of uPAR and subsequently activation of uPAR signaling via regulation of MDM2‐uPAR system

The FASEB Journal, 2018
Human CYP1B1 is known as a major metabolizer for estrogen and shows tumor‐specific hyper‐expression. To explore the role of CYP1B1 on metastasis of human cancer cells, we studied the effects of CYP1B1 inhibition and activation in MCF‐10A, MCF‐7, MDA‐MB‐231, and HeLa cells.
Yeo‐Jung Kwon, Dong‐Jin Ye, Hyoung‐Seok Baek, Young‐Jin Chun   +3 more
openaire   +1 more source

Neutrophils are a main source of circulating suPAR predicting outcome in critical illness

Journal of Intensive Care, 2019
Background Circulating levels of soluble urokinase plasminogen activation receptor (suPAR) have been proposed as a prognostic biomarker in patients with critical illness and sepsis. However, the origin of suPAR in sepsis has remained obscure.
Hendrik Gussen, Philipp Hohlstein, Matthias Bartneck, Klaudia Theresa Warzecha, Lukas Buendgens, Tom Luedde, Christian Trautwein, Alexander Koch, Frank Tacke   +8 more
doaj   +1 more source