The urokinase receptor takes control of cell migration by recruiting integrins and FPR1 on the cell surface. [PDF]
PLoS ONE, 2014 The receptor (uPAR) of the urokinase-type plasminogen activator (uPA) is crucial in cell migration since it concentrates uPA proteolytic activity at the cell surface, binds vitronectin and associates to integrins.
Anna Gorrasi +6 more
doaj +1 more source
Single amino acid substitutions in the chemotactic sequence of urokinase receptor modulate cell migration and invasion. [PDF]
PLoS ONE, 2012 The receptor for urokinase-type plasminogen activator (uPAR) plays an important role in controlling cell migration. uPAR binds urokinase and vitronectin extracellular ligands, and signals in complex with transmembrane receptors such as Formyl-peptide ...
Katia Bifulco +10 more
doaj +1 more source
uPAR: An Essential Factor for Tumor Development [PDF]
Journal of Cancer, 2021 Tumorigenesis is closely related to the loss of control of many genes. Urokinase-type plasminogen activator receptor (uPAR), a glycolipid-anchored protein on the cell surface, is controlled by many factors in tumorigenesis and is expressed in many tumor tissues.
Lv, Tao +8 more
openaire +2 more sources
Cell Adhesion & Migration, 2013 Vascular endothelial growth factor (VEGF)-initiated angiogenesis requires both coordinated proteolytic degradation of extracellular matrix provided by the urokinase plasminogen activator/urokinase receptor (uPA/uPAR) system and regulation of cell-migration provided by integrin-matrix interaction.
Pavel, Uhrin, Johannes M, Breuss
openaire +2 more sources
Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes. [PDF]
PLoS ONE, 2014 The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front.
Synnøve Magnussen +9 more
doaj +1 more source
Clinical and Translational Allergy, 2023 Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown.
Michael A. Portelli +8 more
doaj +1 more source
Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR-/-) Mice. [PDF]
PLoS ONE, 2015 Atherosclerosis, a chronic inflammatory disease, arises from metabolic disorders and is driven by inappropriate recruitment and proliferation of monocytes / macrophages and vascular smooth-muscle-cells.
Jan Larmann +8 more
doaj +1 more source
Pharmaceuticals, 2023 During tumorigenesis, urokinase (uPA) and uPA receptor (uPAR) play essential roles in mediating pathological progression in many cancers. To understand the crosstalk between the uPA/uPAR signaling and cancer, as well as to decipher their cellular ...
Yu-Ching Chang +4 more
doaj +1 more source
Virus-derived serpin reduces immuno-coagulopathic damage in murine colitis by targeting the urokinase-type plasminogen activator receptor (uPAR) and complement. [PDF]
Sci RepLucas AR +23 more
europepmc +3 more sources
Generation of Antibodies to the Urokinase Receptor (uPAR) by DNA Immunization of uPAR Knockout Mice: Membrane‐Bound uPAR is Not Required for an Antibody Response [PDF]
Scandinavian Journal of Immunology, 2003 AbstractThe urokinase receptor (uPAR) is a glycolipid‐anchored cell surface glycoprotein that plays a central role in extracellular proteolysis during tissue remodeling processes including cancer invasion. Furthermore, uPAR is found on the surface of both dendritic cells (DCs) and T cells, and has been proposed to play a role in DC‐induced T‐cell ...
J, Pass +4 more
openaire +2 more sources