Results 31 to 40 of about 14,076 (220)

Reprogramming of VEGF-mediated extracellular matrix changes through autocrine signaling

Cancer Biology & Therapy, 2023
Vascular endothelial growth factor (VEGF) plays key roles in angiogenesis, vasculogenesis, and wound healing. In cancers, including triple negative breast cancer (TNBC), VEGF has been associated with increased invasion and metastasis, processes that ...
Eibhlin Goggins, Yelena Mironchik, Samata Kakkad, Desmond Jacob, Flonne Wildes, Zaver M. Bhujwalla, Balaji Krishnamachary   +6 more
doaj   +1 more source

Production of CD87 Antigen-Specific CAR-T Lymphocytes and Assessment of Their In Vitro Functional Activity

Клиническая онкогематология, 2022
Aim. To generate anti-CD87 CAR-T lymphocytes and to assess their in vitro functional activity. Materials & Methods. Т-lymphocytes isolated from healthy donor peripheral blood were transduced with the anti-CD87-CAR, T2A, and FusionRed gene coding ...
M. V. Neklesova, Sergei Vladimirovich Smirnov, A. A. Shatilova, K. A. Levchuk, A. E. Ershova, S. A. Silonov   +5 more
doaj   +1 more source

Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells

eLife, 2017
The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion.
Michiel van Veen, Elisa Matas-Rico, Koen van de Wetering, Daniela Leyton-Puig, Katarzyna M Kedziora, Valentina De Lorenzi, Yvette Stijf-Bultsma, Bram van den Broek, Kees Jalink, Nicolai Sidenius, Anastassis Perrakis, Wouter H Moolenaar   +11 more
doaj   +1 more source

The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophils. [PDF]

PLoS ONE, 2011
The urokinase-type plasminogen activator receptor (uPAR), a glycosylphosphatidylinositol (GPI) anchored membrane protein, regulates urokinase (uPA) protease activity, chemotaxis, cell-cell interactions, and phagocytosis of apoptotic cells.
Gang Liu, Yanping Yang, Shanzhong Yang, Sami Banerjee, Andressa De Freitas, Arnaud Friggeri, Kasey I Davis, Edward Abraham   +7 more
doaj   +1 more source

Rhenium‐Based β‐Galactosidase Probe Allows Senescence Profiling by Mass Cytometry

Angewandte Chemie, EarlyView.
Senescence‐associated β‐galactosidase (SA‐β‐Gal) activity is a widely accepted biomarker of cellular senescence, yet its integration with other senescence markers has been limited by available detection methods. Here, we introduce ReGal, a mass cytometry‐compatible SA‐β‐Gal activity probe that can be multiplexed with established markers of senescence ...
Adam Tam, Kris Elbein, Aleida G. Gonzalez, Edgar A. Arriaga, Mark Nitz   +4 more
wiley   +2 more sources

Activation of Urokinase Plasminogen Activator and Its Receptor Axis Is Essential for Macrophage Infiltration in a Prostate Cancer Mouse Model

Neoplasia: An International Journal for Oncology Research, 2011
Macrophages within the tumor microenvironment promote angiogenesis, extracellular matrix breakdown, and tumor cell migration, invasion, and metastasis. Activation of the urokinase plasminogen activator (uPA) and its receptor (uPAR) axis promotes prostate
Jian Zhang, Sudha Sud, Kosuke Mizutani, Margaret R. Gyetko, Kenneth J. Pienta   +4 more
doaj   +1 more source

The Association between Plasma Levels of Intact and Cleaved uPAR Levels and the Risk of Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer

Diagnostics, 2020
Radical prostatectomy (RP) is a curatively intended treatment option for clinically localized non-metastatic prostate cancer (PCa). Novel biomarkers could refine treatment choice based on a better identification of men at risk of biochemical recurrence ...
Hein Vincent Stroomberg, Gitte Kristensen, Kasper Drimer Berg, Solvej Lippert, Klaus Brasso, Martin Andreas Røder   +5 more
doaj   +1 more source

Identification of uPAR-positive chemoresistant cells in small cell lung cancer. [PDF]

PLoS ONE, 2007
BACKGROUND: The urokinase plasminogen activator (uPA) and its receptor (uPAR/CD87) are major regulators of extracellular matrix degradation and are involved in cell migration and invasion under physiological and pathological conditions.
Margarita Gutova, Joseph Najbauer, Anna Gevorgyan, Marianne Z Metz, Yehua Weng, Chu-Chih Shih, Karen S Aboody   +6 more
doaj   +1 more source

Human antibody VH domains targeting uPAR as candidate therapeutics for cancers

Frontiers in Oncology, 2023
The high expression of uPAR has been linked to tumor progression, invasion, and metastasis in several types of cancer. Such overexpression of uPAR makes it a potential target for immunotherapies across common cancers such as breast, colorectal, lung ...
Xiaojie Chu, Wei Li, Margaret G. Hines, Ilya Lyakhov, John W. Mellors, John W. Mellors, Dimiter S. Dimitrov, Dimiter S. Dimitrov   +7 more
doaj   +1 more source

Neutrophils are a main source of circulating suPAR predicting outcome in critical illness

Journal of Intensive Care, 2019
Background Circulating levels of soluble urokinase plasminogen activation receptor (suPAR) have been proposed as a prognostic biomarker in patients with critical illness and sepsis. However, the origin of suPAR in sepsis has remained obscure.
Hendrik Gussen, Philipp Hohlstein, Matthias Bartneck, Klaudia Theresa Warzecha, Lukas Buendgens, Tom Luedde, Christian Trautwein, Alexander Koch, Frank Tacke   +8 more
doaj   +1 more source