Results 41 to 50 of about 14,076 (220)

Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells

Cell Adhesion & Migration, 2020
In a tumor microenvironment, endothelial cell migration and angiogenesis allow cancer to spread to other organs causing metastasis.  Indeed, a number of molecules that are involved in cytoskeleton re-organization and intracellular signaling have been ...
Mariana Costa Braga Schmidt, Katia L.P. Morais, Maíra Estanislau Soares de Almeida, Asif Iqbal, Mauricio Barbugiani Goldfeder, Ana Marisa Chudzinski-Tavassi   +5 more
doaj   +1 more source

uPAR Knockout Results in a Deep Glycolytic and OXPHOS Reprogramming in Melanoma and Colon Carcinoma Cell Lines

Cells, 2020
Urokinase Plasminogen Activator (uPA) Receptor (uPAR) is a well-known GPI-anchored three-domain membrane protein with pro-tumor roles largely shown in all the malignant tumors where it is over-expressed.
Alessio Biagioni, Anna Laurenzana, Anastasia Chillà, Mario Del Rosso, Elena Andreucci, Martina Poteti, Daniele Bani, Daniele Guasti, Gabriella Fibbi, Francesca Margheri   +9 more
doaj   +1 more source

Crystal structure and cellular functions of uPAR dimer

Nature Communications, 2022
Abstract Receptor dimerization of urokinase-type plasminogen activator receptor (uPAR) was previously identified at protein level and on cell surface. Recently, a dimeric form of mouse uPAR isoform 2 was proposed to induce kidney disease. Here, we report the crystal structure of human uPAR dimer at 2.96 Å.
Shujuan Yu, Yaqun Sui, Jiawei Wang, Yongdong Li, Hanlin Li, Yingping Cao, Liqing Chen, Longguang Jiang, Cai Yuan, Mingdong Huang   +9 more
openaire   +3 more sources

Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis

Cancer Cell International, 2006
Background The urokinase receptor (uPAR) governs several functions necessary during invasion and metastasis such as motility, degradation of the extracellular matrix and adhesion.
Francis Joseph, Foster Timothy P, Sehgal Inder   +2 more
doaj   +1 more source

An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment

Cancer Biology & Medicine, 2020
Objective: In this study, we aimed to develop an amino-terminal fragment (ATF) peptide-targeted liposome carrying β-elemene (ATF24-PEG-Lipo-β-E) for targeted delivery into urokinase plasminogen activator receptor-overexpressing bladder cancer cells ...
Bingtao Zhai, Peng Chen, Wengang Wang, Shuiping Liu, Jiao Feng, Ting Duan, Yu Xiang, Ruonan Zhang, Mingming Zhang, Xuemeng Han, Xiaying Chen, Qiujie Li, Guohua Li, Ying Liu, Xingxing Huang, Wenzheng Zhang, Ting Pan, Lili Yan, Ting Jin, Tian Xie, Xinbing Sui   +20 more
doaj   +1 more source

Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM). [PDF]

PLoS ONE, 2014
The urokinase plasminogen activator receptor (uPAR) plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has ...
Xiang Xu, Yuan Cai, Ying Wei, Fernando Donate, Jose Juarez, Graham Parry, Liqing Chen, Edward J Meehan, Richard W Ahn, Andrey Ugolkov, Oleksii Dubrovskyi, Thomas V O'Halloran, Mingdong Huang, Andrew P Mazar   +13 more
doaj   +1 more source

Modulation of Cellular Function by the Urokinase Receptor Signalling: A Mechanistic View

Frontiers in Cell and Developmental Biology, 2022
Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease urokinase (uPA), converting plasminogen into plasmin, a broad spectrum ...
Daniela Alfano, Paola Franco, Maria Patrizia Stoppelli   +2 more
doaj   +1 more source

uPAR expression.

, 2019
Immunohistochemical staining of a uPAR positive primary melanoma (a) (x400) and a uPAR expression negative loco-regional metastasis (b) (x 400).
Rita G. Ladstein (6204701), Lars A. Akslen (158246), Ingeborg M. Bachmann (6204698), Cornelia Schuster (158231), Emilia Hugdahl (6204695)   +4 more
core   +1 more source

Diabetes-induced superoxide anion and breakdown of the blood-retinal barrier: role of the VEGF/uPAR pathway. [PDF]

PLoS ONE, 2013
Diabetes-induced breakdown of the blood-retinal barrier (BRB) has been linked to hyperglycemia-induced expression of vascular endothelial growth factor (VEGF) and is likely mediated by an increase in oxidative stress.
Azza B El-Remessy, Telina Franklin, Nagla Ghaley, Jinling Yang, Michael W Brands, Ruth B Caldwell, Mohamed Ali Behzadian   +6 more
doaj   +1 more source

Multilayer Biobased Poly(ethylene furanoate)/Graphene Oxide Nanofibrous Membranes With Directional Water Transport for Efficient Microplastics Filtration

Advanced Materials Technologies, EarlyView.
A self‐assembled multilayer biobased PEF/GO nanofibrous membrane was developed by electrospinning for efficient PLA microplastics (MPs) filtration. The membrane combines superhydrophilicity, directional water transport, mechanical robustness, and a synergistic size‐exclusion interception and electrostatic repulsion MPs separation mechanism, enabling ...
Juraij Kandiyil, Sumayya Ansari, Prasanna Kumar S Mural, Yaser E. Greish, Adnan Younis, Akmal Nazir, Muhammad Z. Iqbal   +6 more
wiley   +1 more source