Results 41 to 50 of about 14,579 (261)

Different Immune Cells Modified With Chimeric Antigen Receptors Are Being Applied to Ovarian Cancer: Which Is the Most Effective? [PDF]

Cancer Med
ABSTRACT Ovarian Cancer (OC), the deadliest gynecological malignancy, poses a major therapeutic challenge in advanced stages owing to its high recurrence rate and metastatic potential. In this regard, it is noteworthy that immunotherapy has recently gained significant attention in OC treatment, a phenomenon attributable to notable advances in over‐the ...
Wang L, Cao Y, Ren Y, Zhang Y, Wang L.
europepmc   +2 more sources

Fortalecimiento de las habilidades comunicativas: leer y escribir, mediante el análisis de canciones vallenatas tradicionales con estudiantes del grado quinto

Revista UNIMAR, 2023
El fortalecimiento de las habilidades comunicativas permite desenvolverse diariamente, por ello, el objetivo de esta investigación fue fortalecer las habilidades comunicativas: leer y escribir, mediante el análisis de canciones vallenatas tradicionales ...
Gina Katherine Britto Jiménez, Virginia Esther Villalba Contreras, Álvaro Enrique Bovea Ramos   +2 more
doaj   +1 more source

Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes [PDF]

, 2012
mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression in cancer cells affects tumor biologically relevant processes.
Sato, Sumito, Soelch, Susanne, Luther, Thomas, Schmitt, Manfred, Baretton, Gustavo, Grismayer, Bettina, Kopitz, Charlotte, Krueger, Achim, Kotzsch, Matthias, Ries, Christian, Magdolen, Viktor   +10 more
core   +1 more source

TLR4 Response to LPS Is Reinforced by Urokinase Receptor

Frontiers in Immunology, 2020
GPI-anchored uPAR is the receptor for the extracellular serine protease urokinase-type plasminogen activator (uPA). Though uPAR role in inflammatory processes is documented, underlying mechanisms are not fully understood.
Yulia Kiyan, Sergey Tkachuk, Song Rong, Anna Gorrasi, Pia Ragno, Inna Dumler, Hermann Haller, Nelli Shushakova, Nelli Shushakova   +8 more
doaj   +1 more source

Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) [PDF]

, 2001
Urokinase-type plasminogen activator (uPA) represents a central molecule in pericellular proteolysis and is implicated in a variety of physiological and pathophysiological processes such as tissue remodelling, wound healing, tumor invasion, and ...
Kellermann, Josef, Wilhelm, Olaf G., Riemer, Christoph, Bürgle, Markus, Schroeck, Florian, Schmitt, Manfred, Kessler, Horst, Degitz, Klaus, Arroyo de Prada, Nuria, Schmiedeberg, Niko, Magdolen, Viktor   +10 more
core   +1 more source

Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils Via Mac-1, But Independently of Urokinase-Type Plasminogen Activator Receptor [PDF]

, 2011
Background: Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear.
Paul J. Declerck, Rehberg, Markus, Daniel Puhr-Westerheide, Lerchenberger, Max, Uhl, Bernd, Kanse, Sandip, Johanna Liebl, Reichel, Christoph A., Bernd Uhl, Markus Rehberg, Zahler, Stefan, Lorenzl, Stefan, Elisabeth Deindl, Khandoga, Andrej, Declerck, Paul J., Stefan Zahler, Schmalix, Wolfgang, Fritz Krombach, Liebl, Johanna, Christoph A. Reichel, Krombach, Fritz, Max Lerchenberger, Andrej Khandoga, Stefan Lorenzl, Deindl, Elisabeth, Wolfgang Schmalix, Puhr-Westerheide, Daniel, Sandip Kanse   +27 more
core   +1 more source

The urokinase receptor/uPAR is a major effector of p53 gain-of-function mutations in gemcitabine-treated pancreatic ductal adenocarcinoma. [PDF]

J Biol Chem
Zampieri C, Kouhmareh K, Sartipdolagh P, Azmoon P, Klemke RL, Gonias SL.   +5 more
europepmc   +3 more sources

Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor – β1 (TGF-β1) and potential effects on migration and invasion

BMC Cancer, 2017
Background Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression.
Synnove Norvoll Magnussen, Elin Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane Cavalcanti Jacobsen, Bente Mortensen, Tuula Salo, Inigo Martinez-Zubiaurre, Jan-Olof Winberg, Lars Uhlin-Hansen, Gunbjorg Svineng   +10 more
doaj   +1 more source

Efferocytosis: another function of uPAR

Blood, 2009
uPAR, the receptor for urokinase plasminogen activator, is a regulator of the uptake by macrophages of apoptotic neutrophils (efferocytosis). Its role and mechanism appear to be complex and possibly controversial.
Blasi, Francesco, Sidenius, Nicolai
openaire   +3 more sources

Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells

eLife, 2017
The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion.
Michiel van Veen, Elisa Matas-Rico, Koen van de Wetering, Daniela Leyton-Puig, Katarzyna M Kedziora, Valentina De Lorenzi, Yvette Stijf-Bultsma, Bram van den Broek, Kees Jalink, Nicolai Sidenius, Anastassis Perrakis, Wouter H Moolenaar   +11 more
doaj   +1 more source