Results 61 to 70 of about 14,579 (261)

Activation of Urokinase Plasminogen Activator and Its Receptor Axis Is Essential for Macrophage Infiltration in a Prostate Cancer Mouse Model

Neoplasia: An International Journal for Oncology Research, 2011
Macrophages within the tumor microenvironment promote angiogenesis, extracellular matrix breakdown, and tumor cell migration, invasion, and metastasis. Activation of the urokinase plasminogen activator (uPA) and its receptor (uPAR) axis promotes prostate
Jian Zhang, Sudha Sud, Kosuke Mizutani, Margaret R. Gyetko, Kenneth J. Pienta   +4 more
doaj   +1 more source

Neutrophils are a main source of circulating suPAR predicting outcome in critical illness

Journal of Intensive Care, 2019
Background Circulating levels of soluble urokinase plasminogen activation receptor (suPAR) have been proposed as a prognostic biomarker in patients with critical illness and sepsis. However, the origin of suPAR in sepsis has remained obscure.
Hendrik Gussen, Philipp Hohlstein, Matthias Bartneck, Klaudia Theresa Warzecha, Lukas Buendgens, Tom Luedde, Christian Trautwein, Alexander Koch, Frank Tacke   +8 more
doaj   +1 more source

uPAR+ extracellular vesicles: a robust biomarker of resistance to checkpoint inhibitor immunotherapy in metastatic melanoma patients

Journal for ImmunoTherapy of Cancer, 2021
Background Emerging evidence has highlighted the importance of extracellular vesicle (EV)-based biomarkers of resistance to immunotherapy with checkpoint inhibitors in metastatic melanoma.
Michele Guida, Letizia Porcelli, Simona De Summa, Roberta Di Fonte, Ivana De Risi, Marianna Garofoli, Mariapia Caputo, Antonio Negri, Sabino Strippoli, Simona Serratì, Amalia Azzariti   +10 more
doaj   +1 more source

uPAR expression.

, 2019
Immunohistochemical staining of a uPAR positive primary melanoma (a) (x400) and a uPAR expression negative loco-regional metastasis (b) (x 400).
Rita G. Ladstein (6204701), Lars A. Akslen (158246), Ingeborg M. Bachmann (6204698), Cornelia Schuster (158231), Emilia Hugdahl (6204695)   +4 more
core   +1 more source

VEGF-initiated angiogenesis and the uPA/uPAR system [PDF]

Cell Adhesion & Migration, 2012
Angiogenesis involves a series of tightly regulated cellular processes initiated primarily by the vascular endothelial growth factor (VEGF). The urokinase-type plasminogen activator system, consisting of the urokinase-type plasminogen activator (uPA), its cellular receptor uPAR and its inhibitor PAI-1, participates in the realization of these VEGF ...
Johannes M, Breuss, Pavel, Uhrin
openaire   +2 more sources

uPAR expression controls cell migration.

, 2014
uPAR-293 and V-293 cells efficiently migrate toward serum growth factors or EGF (GF). However, uPAR, when expressed, recruits and bridges fMLFRs and β1 integrin at the cell surface, thus driving pro-migratory signaling (upper panels).
Nunzia Montuori (511913), Giuseppina Amodio (511911), Pia Ragno (342854), Paolo Remondelli (511912), Anna Li Santi (511910), Daniela Alfano (342853), Anna Gorrasi (511909)   +6 more
core   +1 more source

EGFR/uPAR interaction as druggable target to overcome vemurafenib acquired resistance in melanoma cellsResearch in context

EBioMedicine, 2019
Background: BRAF inhibitor (BRAF-I) therapy for melanoma patients harboring the V600E mutation is initially highly effective, but almost all patients relapse within a few months.
Anna Laurenzana, Francesca Margheri, Alessio Biagioni, Anastasia Chillà, Nicola Pimpinelli, Jessica Ruzzolini, Silvia Peppicelli, Elena Andreucci, Lido Calorini, Simona Serratì, Mario Del Rosso, Gabriella Fibbi   +11 more
doaj   +1 more source

uPAR Knockout Results in a Deep Glycolytic and OXPHOS Reprogramming in Melanoma and Colon Carcinoma Cell Lines

Cells, 2020
Urokinase Plasminogen Activator (uPA) Receptor (uPAR) is a well-known GPI-anchored three-domain membrane protein with pro-tumor roles largely shown in all the malignant tumors where it is over-expressed.
Alessio Biagioni, Anna Laurenzana, Anastasia Chillà, Mario Del Rosso, Elena Andreucci, Martina Poteti, Daniele Bani, Daniele Guasti, Gabriella Fibbi, Francesca Margheri   +9 more
doaj   +1 more source

Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]

, 2014
Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Portelli, Michael A., Hall, Ian P., Sayers, Ian   +2 more
core  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source