Results 61 to 70 of about 14,076 (220)

Urokinase-Type Plasminogen Activator System in Norm and in Life-Threatening Processes (Review)

Общая реаниматология, 2018
The multifunctional urokinase-type plasminogen activator system (uPA-system) includes serine proteinase — uPA or urokinase, its receptor (uPAR) and two inhibitors (PAI-1 and PAI-2).
Elena V. Kugaevskaya, Tatiana A. Gureeva, Olga S. Timoshenko, Nina I. Solovyeva   +3 more
doaj   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

VEGF-initiated angiogenesis and the uPA/uPAR system [PDF]

Cell Adhesion & Migration, 2012
Angiogenesis involves a series of tightly regulated cellular processes initiated primarily by the vascular endothelial growth factor (VEGF). The urokinase-type plasminogen activator system, consisting of the urokinase-type plasminogen activator (uPA), its cellular receptor uPAR and its inhibitor PAI-1, participates in the realization of these VEGF ...
Johannes M, Breuss, Pavel, Uhrin
openaire   +2 more sources

Baseline podocyte‐associated state and persistent cell–matrix transcriptional programs are associated with BALB/c substrain differences in adriamycin nephropathy

Animal Models and Experimental Medicine, EarlyView.
Two closely related BALB/c substrains exhibit different early responses to adriamycin (ADR)‐induced nephropathy. BALB/cByJcl mice showed lower baseline WT1‐positive nuclei counts and NPHS1 immunoreactivity than BALB/cAJcl mice, together with extracellular matrix and integrin programs that were enriched at baseline and persisted at Day 5.
Ryuya Nakagawa, Masaki Watanabe, Koyuki Kawamoto, Momoka Hiratsuka, Takeru Sasaki, Nobuya Sasaki   +5 more
wiley   +1 more source

Expression of uPAR in Urinary Podocytes of Patients with Fabry Disease

International Journal of Nephrology, 2017
Background. Despite enzyme replacement therapy, Fabry nephropathy still progresses. Podocyturia is an irreversible event that antedates proteinuria and leads to chronic renal failure.
Hernán Trimarchi, Romina Canzonieri, Amalia Schiel, Juan Politei, Cristian Costales-Collaguazo, Aníbal Stern, Matías Paulero, Tatiana Rengel, Lara Valiño-Rivas, Mariano Forrester, Fernando Lombi, Vanesa Pomeranz, Romina Iriarte, Alexis Muryan, Alberto Ortiz, María Dolores Sanchez-Niño, Elsa Zotta   +16 more
doaj   +1 more source

TGF-β regulation of the uPA/uPAR axis modulates mesothelial-mesenchymal transition (MesoMT)

Scientific Reports, 2021
Pleural fibrosis (PF) is a chronic and progressive lung disease which affects approximately 30,000 people per year in the United States. Injury and sustained inflammation of the pleural space can result in PF, restricting lung expansion and impairing ...
Ranisha Logan, Ann Jeffers, Wenyi Qin, Shuzi Owens, Prashant Chauhan, Satoshi Komatsu, Mitsuo Ikebe, Steven Idell, Torry A. Tucker   +8 more
doaj   +1 more source

uPAR co-immunoprecipitates with fMLF-Rs.

, 2014
A: Lysates of uPAR-293 cells or V-293 cells, transiently transfected with FPR1 cDNA, were analyzed by Western blot with a uPAR-specific monoclonal antibody or immunoprecipitated with anti-FPR1 polyclonal antibodies or nonimmune rabbit immunoglobulins and
Nunzia Montuori (511913), Giuseppina Amodio (511911), Pia Ragno (342854), Paolo Remondelli (511912), Anna Li Santi (511910), Daniela Alfano (342853), Anna Gorrasi (511909)   +6 more
core   +1 more source

Let-7 Family microRNAs Regulate the Expression of the Urokinase-Receptor in Acute Myeloid Leukemia Cells

Cells
The urokinase-receptor (uPAR) exerts multiple functions supporting most cancer hallmarks. Increased uPAR expression is associated with an unfavorable prognosis in several cancer types, including hematologic malignancies. We previously reported that three
Anna Li Santi, Mariaevelina Alfieri, Luigia Meo, Pia Ragno   +3 more
doaj   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

uPAR's signaling two step [PDF]

The Journal of Cell Biology, 2007
The uPA receptor (uPAR) is a loner. Jutting from the plasma membrane, it has no apparent connection to the cell interior. But, as Madsen et al. demonstrate on page 927, uPAR induces cells to cling tightly to a surface. The behavior might recruit other receptors and explain how the seemingly isolated uPAR exerts its influence.
openaire   +1 more source