Results 71 to 80 of about 14,530 (214)
Data in Brief, 2017 The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins.
Degryse, Bernard +7 more
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VEGF-initiated angiogenesis and the uPA/uPAR system [PDF]
Cell Adhesion & Migration, 2012 Angiogenesis involves a series of tightly regulated cellular processes initiated primarily by the vascular endothelial growth factor (VEGF). The urokinase-type plasminogen activator system, consisting of the urokinase-type plasminogen activator (uPA), its cellular receptor uPAR and its inhibitor PAI-1, participates in the realization of these VEGF ...
Johannes M, Breuss, Pavel, Uhrin
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uPAR is found in endocytic compartments in the absence of ligands in HEK293-uPAR cells.
, 2013 Immunofluorescence of HEK293-uPAR cells labeled with a polyclonal anti-uPAR antibody and imaged by confocal microscopy. Image 2 (left), shows the predominant location of uPAR in lamellipodia-like protrusions and in intracellular compartments, including ...
Francesco Blasi (61418) +4 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 22, Page 6685-6703, November 2026.Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier +2 more
wiley +1 more source
FPR1 co-localizes with uPAR on the surface of uPAR-expressing HEK-293 cells.
, 2014 HEK-293 cells stably transfected with uPAR cDNA (uPAR-293 cells) were seeded on glass coverslips and transiently transfected with FPR1 cDNA. After 24 h, cells were incubated for further 24 h in culture medium (DMEM) containing 10% serum (Basal) or in ...
Nunzia Montuori (511913) +6 more
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Histopathology, Volume 89, Issue 5, Page 835-848, November 2026.TAC/SARIFA, defined by direct tumour–adipocyte contact at the invasion front, represents a reproducible, biologically meaningful H&E biomarker with consistent adverse prognostic associations in CRC. Aims Direct tumour‐adipocyte interaction at the invasion front, termed Stroma AReactive Invasion Front Areas (SARIFA), has recently emerged as a novel H&E ...
Nic G Reitsam +3 more
wiley +1 more source
uPAR's signaling two step [PDF]
The Journal of Cell Biology, 2007 The uPA receptor (uPAR) is a loner. Jutting from the plasma membrane, it has no apparent connection to the cell interior. But, as Madsen et al. demonstrate on page 927, uPAR induces cells to cling tightly to a surface. The behavior might recruit other receptors and explain how the seemingly isolated uPAR exerts its influence.
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Copenhagen uPAR prostate cancer (CuPCa) database:protocol and early results
, 2016 AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels
Iversen, Peter +7 more
core +1 more source
BiomedicinesThe urokinase-type plasminogen activator receptor (uPAR) is a unique protease binding receptor, now recognized as a key regulator of inflammation.
Mostafa Hamada +9 more
doaj +1 more source
Reprogramming of VEGF-mediated extracellular matrix changes through autocrine signaling
Cancer Biology & Therapy, 2023 Vascular endothelial growth factor (VEGF) plays key roles in angiogenesis, vasculogenesis, and wound healing. In cancers, including triple negative breast cancer (TNBC), VEGF has been associated with increased invasion and metastasis, processes that ...
Eibhlin Goggins +6 more
doaj +1 more source