Results 81 to 90 of about 14,530 (214)

Lipoprotein(a), Endothelial Dysfunction and Cardiovascular Disease

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Lipoprotein(a) (Lp(a)) is a particle similar to low‐density lipoprotein cholesterol and is associated with apolipoprotein (A). High Lp(a) levels are a genetic, independent risk factor for atherosclerotic cardiovascular disease (ASCVD). Endothelial cells, which form the continuous lining of the cardiovascular system, are crucial for vascular ...
Xianghui Zhou, Xiyuan Fang, Xin Zhou, Zhao Zhang, Yu Hu, Zhipeng Cheng   +5 more
wiley   +1 more source

uPAR carrying S90E and S90P substitutions. A

, 2012
: Arg91 and Tyr92 superposition of the backbone atoms of the various 88–92 segments of SuPAR from x-ray structures. Residue 89 is not visible in the electron density map of 1YWH. Side chains are reported as stick, Arg residues are in blue.
Katia Bifulco (133627), Vincenzo Pavone (133641), Giuseppe Pirozzi (133651), Paola Franco (133638), Claudio Arra (133331), Maria Teresa Masucci (133648), Maria Vincenza Carriero (133657), Immacolata Longanesi-Cattani (133632), Pietro Mugione (133644), Maria Patrizia Stoppelli (133653), Gioconda Di Carluccio (133646)   +10 more
core   +1 more source

MO009NEUTRALIZATION OF UPAR WITH AN ANTI-UPAR ANTIBODY AMELIORATES RECURRENT FSGS SERA INDUCED PODOCYTE INJURY

Nephrology Dialysis Transplantation, 2020
Abstract Background and Aims The role of suPAR as a biomarker and/or causative factor in the pathogenesis of recurrent FSGS remains unclear (Harel E., et al. Transplantation 2020; 104:54-60). While anti-suPAR antibodies have been shown to block suPAR induced podocyte injury in mouse models of FSGS ...
Minnie Sarwal, Charles Craik, Jun Shoji, Andrea Alice Da Silva, Priyanka Rashmi, Flavio Vincenti   +5 more
openaire   +1 more source

Urokinase-type plasminogen activator receptor combined with modified Alvarado scoring system and C-reactive protein for diagnosis of acute appendicitis in children

Di-san junyi daxue xuebao, 2020
Objective To investigate the serum level of urokinase-type plasminogen activator receptor (uPAR) in children with acute appendicitis and assess the diagnostic value of uPAR combined with C-reactive protein (CRP) and modified Alvarado score for acute ...
SUN Chuanwei, LI Aijun, SUN Hong, ZHANG Wei, WANG Guibo, LEI Jie, YANG Zhonggang   +6 more
doaj   +1 more source

Multilayer Biobased Poly(ethylene furanoate)/Graphene Oxide Nanofibrous Membranes With Directional Water Transport for Efficient Microplastics Filtration

Advanced Materials Technologies, Volume 11, Issue 20, 21 October 2026.
A self‐assembled multilayer biobased PEF/GO nanofibrous membrane was developed by electrospinning for efficient PLA microplastics (MPs) filtration. The membrane combines superhydrophilicity, directional water transport, mechanical robustness, and a synergistic size‐exclusion interception and electrostatic repulsion MPs separation mechanism, enabling ...
Juraij Kandiyil, Sumayya Ansari, Prasanna Kumar S Mural, Yaser E. Greish, Adnan Younis, Akmal Nazir, Muhammad Z. Iqbal   +6 more
wiley   +1 more source

Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma.

PLoS ONE, 2012
BackgroundMedulloblastoma is a highly invasive cancer of central nervous system diagnosed mainly in children. Matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator receptor (uPAR) are over expressed in several cancers and well ...
Ramaprasada Rao Kotipatruni, Arun Kumar Nalla, Swapna Asuthkar, Christopher S Gondi, Dzung H Dinh, Jasti S Rao   +5 more
doaj   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Amiloride inhibits uPAR constitutive uptake in a dose-dependent manner.

, 2013
Panel A. Biotinylation experiments in HEK293-uPAR cells incubated in the absence or presence of amiloride. Lane 1: background, Lane 2: constitutively internalized uPAR, Lane 3: inhibition by amiloride.
Francesco Blasi (61418), Carlo Tacchetti (252415), Katia Cortese (166183), Macarena Sahores (375932), Chris D. Madsen (375934)   +4 more
core   +1 more source

Urokinase‐type plasminogen activator receptor (uPAR) on tumor‐associated macrophages is a marker of poor prognosis in colorectal cancer [PDF]

, 2014
Patients were identified from a population-based prospective study of 4990 individuals with symptoms associated with colorectal cancer (CRC). A total of 244 CRC tissue samples were available for immunohistochemical staining of uPAR, semiquantitatively ...
Hans Jørgen Nielsen, Laerum, Ole Didrik, Illemann, Martin, Nielsen, Hans Jørgen, Hasselby, Jane Preuss, Jane Preuss Hasselby, Ole Didrik Laerum, Ib Jarle Christensen, Thurison, Tine, Christensen, Ib Jarle, Martin Illemann, Gunilla Høyer‐Hansen, Høyer-Hansen, Gunilla, Tine Thurison, Laurberg, Søren, Rahr, Hans B., Nielsen, Knud T, Jørgensen, Lars Nannestad, Olsen, Jesper   +18 more
core   +2 more sources

uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder--Possible Clinical Implications.

PLoS ONE, 2015
The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder.
Line Hammer Dohn, Helle Pappot, Benedikte Richter Iversen, Martin Illemann, Gunilla Høyer-Hansen, Ib Jarle Christensen, Peter Thind, Lisbeth Salling, Hans von der Maase, Ole Didrik Laerum   +9 more
doaj   +1 more source