Results 81 to 90 of about 14,579 (261)

Diabetes-induced superoxide anion and breakdown of the blood-retinal barrier: role of the VEGF/uPAR pathway. [PDF]

PLoS ONE, 2013
Diabetes-induced breakdown of the blood-retinal barrier (BRB) has been linked to hyperglycemia-induced expression of vascular endothelial growth factor (VEGF) and is likely mediated by an increase in oxidative stress.
Azza B El-Remessy, Telina Franklin, Nagla Ghaley, Jinling Yang, Michael W Brands, Ruth B Caldwell, Mohamed Ali Behzadian   +6 more
doaj   +1 more source

uPAR co-immunoprecipitates with fMLF-Rs.

, 2014
A: Lysates of uPAR-293 cells or V-293 cells, transiently transfected with FPR1 cDNA, were analyzed by Western blot with a uPAR-specific monoclonal antibody or immunoprecipitated with anti-FPR1 polyclonal antibodies or nonimmune rabbit immunoglobulins and
Nunzia Montuori (511913), Giuseppina Amodio (511911), Pia Ragno (342854), Paolo Remondelli (511912), Anna Li Santi (511910), Daniela Alfano (342853), Anna Gorrasi (511909)   +6 more
core   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

#5677 UPAR ACTIVATION BY UPARANT INDUCED FUNCTIONAL AND STRUCTURAL RECOVERY OF PODOCYTES AFTER FSGS-SERUM DAMAGE

Nephrology Dialysis Transplantation, 2023
Abstract Background and Aims Idiopathic focal segmental glomerular sclerosis (FSGS) is characterized by progressive damage to the renal parenchyma leading to end-stage renal disease, frequent recurrence after kidney transplantation and no specific therapeutic intervention.
Mattinzoli Deborah, Armelloni Silvia, LI Min, Dalonzo Daniele, Defenza Maria, Ikehata Masami, Alfieri Carlo Maria, Pavone Vincenzo, Castellano Giuseppe   +8 more
openaire   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

uPAR's signaling two step [PDF]

The Journal of Cell Biology, 2007
The uPA receptor (uPAR) is a loner. Jutting from the plasma membrane, it has no apparent connection to the cell interior. But, as Madsen et al. demonstrate on page 927, uPAR induces cells to cling tightly to a surface. The behavior might recruit other receptors and explain how the seemingly isolated uPAR exerts its influence.
openaire   +1 more source

TGF-β regulation of the uPA/uPAR axis modulates mesothelial-mesenchymal transition (MesoMT)

Scientific Reports, 2021
Pleural fibrosis (PF) is a chronic and progressive lung disease which affects approximately 30,000 people per year in the United States. Injury and sustained inflammation of the pleural space can result in PF, restricting lung expansion and impairing ...
Ranisha Logan, Ann Jeffers, Wenyi Qin, Shuzi Owens, Prashant Chauhan, Satoshi Komatsu, Mitsuo Ikebe, Steven Idell, Torry A. Tucker   +8 more
doaj   +1 more source

Staining intensities of uPAR^E (a; stained with anti-uPAR #3937 MAb) and uPAR^S (b; stained with anti-uPAR R4 MAb) were evaluated as negative, weak, moderate or strong.

, 2015
Peritumoral accentuation of uPAR (i.e., uPARPT; uPAR expression in stroma-associated cells and concentrated around the tumour epithelium) represented in (c), stained with R4.
Julie Fletcher (562693), Seong Beom Ahn (562691), Mark S. Baker (562698), Sun Young Kwun (562694), Charles Chan (9232), Candice Clarke (562695), Abidali Mohamedali (562692), Pierre H. Chapuis (562697), Owen F. Dent (562696), Edouard C. Nice (233922)   +9 more
core   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source