Results 101 to 110 of about 14,076 (220)
Amiloride inhibits uPAR constitutive uptake in a dose-dependent manner.
, 2013 Panel A. Biotinylation experiments in HEK293-uPAR cells incubated in the absence or presence of amiloride. Lane 1: background, Lane 2: constitutively internalized uPAR, Lane 3: inhibition by amiloride.
Francesco Blasi (61418) +4 more
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BMC Cancer, 2010 Background uPAR and MMP-9, which play critical roles in tumor cell invasion, migration and angiogenesis, have been shown to be associated with lipid rafts.
Estes Norman +5 more
doaj +1 more source
The uPA/uPAR system in astrocytic wound healing
Neural Regeneration Research, 2022 The repair of injured tissue is a highly complex process that involves cell proliferation, differentiation, and migration. Cell migration requires the dismantling of intercellular contacts in the injured zone and their subsequent reconstitution in the wounded area. Urokinase-type plasminogen activator (uPA) is a serine proteinase found in multiple cell
openaire +3 more sources
, 2018 All cells in the model (A) express the same level of uPAR (the uPAR concentration in the cells is indicated by the red color) at initialization of a simulation.
Joao Carvalho (5487974) +6 more
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BMC Cancer, 2017 Background Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF) and Epidermal Growth Factor ...
Anders Christensen +11 more
doaj +1 more source
Urokinase Receptor and Resistance to Targeted Anticancer Agents
Frontiers in Pharmacology, 2015 The urokinase receptor/uPAR is a GPI-anchored membrane protein, which regulates protease activity at the cell surface and, in collaboration with a system of co-receptors, triggers cell-signaling and regulates gene expression within the cell.
Steven L. Gonias, Jingjing eHu
doaj +1 more source
Ultrastructural visualization of uPAR endocytic vesicles.
, 2013 HEK293-uPAR cells were incubated with anti-uPAR monoclonal antibody R3 (that recognizes the D1 extracellular domain) at 4°C for 20 minutes, washed and then probed with protein A gold 10 nm in the absence and in the presence of 200 nM RAP. After extensive
Francesco Blasi (61418) +4 more
core +1 more source
Cytoplasmic and membrane staining of uPAR.
, 2014 Representative photomicrographs of tissue microarray sections stained for uPAR, showing typical A) membrane and B) cytoplasmic localized staining of the tumour cells. Scalebar = 50 µm.
Lars Uhlin-Hansen (350451) +5 more
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uPAR is not required for skeletal muscle regeneration
The FASEB Journal, 2006 Muscle regeneration has been shown to be severely impaired in urokinase‐type plasminogen activator deficient (uPA‐/‐) mice, and the impaired regeneration was associated with a lack of macrophage accumulation following muscle injury. Many studies have demonstrated that the receptor for uPA (uPAR) plays an important role in inflammatory cell migration ...
Scott C Bryer, Timothy J Koh
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Abstract 831: uPAR Expression is Up-regulated in Cervical Cancer
, 2010 Hypoxia occurs during development of cervical cancer and is considered to correlate with its invasion. Hypoxia induces cancer cells to have more invasive property through the urokinase plasminogen activator receptor (uPAR) expression.
Hirotaka Nishi +6 more
core +1 more source