Results 101 to 110 of about 14,530 (214)

The uPA/uPAR system in astrocytic wound healing

Neural Regeneration Research, 2022
The repair of injured tissue is a highly complex process that involves cell proliferation, differentiation, and migration. Cell migration requires the dismantling of intercellular contacts in the injured zone and their subsequent reconstitution in the wounded area. Urokinase-type plasminogen activator (uPA) is a serine proteinase found in multiple cell
openaire   +3 more sources

Prospective phase II trial of [68Ga]Ga-NOTA-AE105 uPAR-PET/MRI in patients with primary gliomas: Prognostic value and Implications for uPAR-targeted Radionuclide Therapy

EJNMMI Research
Background Treatment of patients with low-grade and high-grade gliomas is highly variable due to the large difference in survival expectancy. New non-invasive tools are needed for risk stratification prior to treatment.
Aleena Azam, Sorel Kurbegovic, Esben Andreas Carlsen, Thomas Lund Andersen, Vibeke André Larsen, Ian Law, Jane Skjøth-Rasmussen, Andreas Kjaer   +7 more
doaj   +1 more source

Small-Molecule Inhibition of the uPAR uPA Interaction by Conformational Selection

, 2020
The urokinase receptor (uPAR) is a cell surface receptor that binds to the serine protease urokinase-type plasminogen activator (uPA) with high affinity.
David Xu, Ploug, Michael, Mona K. Ghozayel, Xu, David, Bum-Erdene, Khuchtumur, Leth, Julie M., Michael Ploug, Samy O. Meroueh, Ghozayel, Mona K., Khuchtumur Bum‐Erdene, Meroueh, Samy O., Julie M. Leth   +11 more
core   +1 more source

Urokinase-Type Plasminogen Activator System in Norm and in Life-Threatening Processes (Review)

Общая реаниматология, 2018
The multifunctional urokinase-type plasminogen activator system (uPA-system) includes serine proteinase — uPA or urokinase, its receptor (uPAR) and two inhibitors (PAI-1 and PAI-2).
Elena V. Kugaevskaya, Tatiana A. Gureeva, Olga S. Timoshenko, Nina I. Solovyeva   +3 more
doaj   +1 more source

Prognosis in adenocarcinomas of lower oesophagus, gastro-oesophageal junction and cardia evaluated by uPAR-immunohistochemistry

, 2011
Adenocarcinomas of lower oesophagus, gastro-oesophageal junction and cardia in humans are highly invasive tumours with poor prognosis. The localisation of urokinase-type plasminogen activator receptor (uPAR) was determined in 66 patients; 60 with ...
Laerum, Ole Didrik, Helgeland, Lars, Illemann, Martin, Skarstein, Arne, Warner Alpízar-Alpízar, Nielsen, Boye Schnack, Ole Didrik Laerum, Arne Skarstein, Ib Jarle Christensen, Christensen, Ib Jarle, Boye Schnack Nielsen, Lars Helgeland, Alpizar, Warner Enrique Alpizar, Keld Danø, Danø, Keld, Martin Illemann, Ovrebo, Kjell, Kjell Ovrebo   +17 more
core   +1 more source

uPAR enhances malignant potential of triple-negative breast cancer by directly interacting with uPA and IGF1R [PDF]

, 2016
Immunohistochemical analysis and PLA of uPAR and IGF1R in MDA-MB-231 and control cells. a: Differential protein expressions of uPAR or IGF1R in mock and uPAR-depleted MDA-MB-231 cells or in MCF7 (b) and SKBR3 (d) cells.
Katrin Lindner (3474770), Rebecca Mall, Axel Walch, Braselmann, Herbert, Eva Gross, Michaela Aubele, Mall, Rebecca, Katrin Lindner, Gross, Eva, Huber, M., Manfred Schmitt, Michaela Huber (3474761), Natalie Falkenberg, Falkenberg, N., Herbert Braselmann (125383), Mall, R., Michaela Aubele (2270650), Walch, A.K., Herbert Braselmann, Annette Feuchtinger, Sara Molatore (3474767), Schmitt, M., Feuchtinger, A., Molatore, Sara, Gross, E., Lindner, K., Michaela C. Huber, Falkenberg, Natalie, Molatore, S., Aubele, M., Rebecca Mall (3474764), Axel Walch (149177), Sara Molatore, Huber, Michaela C., Walch, Axel, Schmitt, Manfred, Braselmann, H., Manfred Schmitt (223598), Natalie Falkenberg (3474758), Feuchtinger, Annette, Annette Feuchtinger (432883), Eva Gross (268302), Aubele, Michaela, Lindner, Katrin, Huber, Michaela C.;Mall, Rebecca;Braselmann, Herbert;Feuchtinger, Annette;Molatore, Sara;Lindner, Katrin;Walch, Axel;Gross, Eva;Schmitt, Manfred;Falkenberg, Natalie;Aubele, Michaela   +44 more
core   +2 more sources

uPAR REGULATES PERICELLULAR PROTEOLYSIS THROUGH A MECHANISM INVOLVING INTEGRINS AND fMLF-RECEPTORS

, 2013
The expression of the urokinase-type plasminogen activator (uPA) and its receptor (uPAR) can be regulated by several hormones, cytokines, and tumour promoters.
REA, VINCENZA ELENA ANNA, Loredana Rinaldi, RAGNO, Pia, Vincenza Elena Anna Rea, Daniela Alfano, Nunzia Montuori, V. Cosimato, D. Alfano, Vincenzo Cosimato, MONTUORI, NUNZIA, L. Rinaldi, P. Ragno, Ragno Pia, Rinaldi Loredana, Rea Vincenza Elena Anna, Cosimato Vincenzo, Alfano Daniela, Montuori Nunzia   +17 more
core   +1 more source

Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

, 2008
The cellular receptor for urokinase, uPAR, localizes its ligand, uPA, and thereby the plasminogen activation, to the cell surface. uPA also cleaves uPAR, liberating the ligand-binding domain I, and thereby inactivates the binding potential of uPAR for ...
Lund, I.K., Almasi, Charlotte Elberling, Rasch, M.G., Hoyer-Hansen, G.   +3 more
core   +1 more source

Urokinase Receptor and Resistance to Targeted Anticancer Agents

Frontiers in Pharmacology, 2015
The urokinase receptor/uPAR is a GPI-anchored membrane protein, which regulates protease activity at the cell surface and, in collaboration with a system of co-receptors, triggers cell-signaling and regulates gene expression within the cell.
Steven L. Gonias, Jingjing eHu
doaj   +1 more source

Spontaneous ‘uPAR-rich’ cell selection in the monolayer by a uPAR-plasmin-TGFβ1 positive feedback loop.

, 2018
All cells in the model (A) express the same level of uPAR (the uPAR concentration in the cells is indicated by the red color) at initialization of a simulation.
Joao Carvalho (5487974), Marloes van den Broek (5487980), Sonja E. M. Boas (5487977), Marie-José Goumans (516094), Pieter Koolwijk (284312), Ester M. Weijers (755095), Roeland M. H. Merks (53978)   +6 more
core   +1 more source