Results 101 to 110 of about 14,579 (261)
Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues
Advanced Materials, Volume 38, Issue 27, 14 May 2026.A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad +6 more
wiley +1 more source
Molecular Oncology, EarlyView.RETRACTION: S. Gopinath, K. Alapati, R. R. Malla, C. S. Gondi, S. Mohanam, D. H. Dinh, and J. S. Rao, “Mechanism of p27 Upregulation Induced by Downregulation of Cathepsin B and Upar in Glioma,” Molecular Oncology 5, no. 5 (2011): 426–437, https://doi.org/10.1016/j.molonc.2011.07.004.
wiley +1 more source
The uPA/uPAR system in astrocytic wound healing
Neural Regeneration Research, 2022 The repair of injured tissue is a highly complex process that involves cell proliferation, differentiation, and migration. Cell migration requires the dismantling of intercellular contacts in the injured zone and their subsequent reconstitution in the wounded area. Urokinase-type plasminogen activator (uPA) is a serine proteinase found in multiple cell
openaire +3 more sources
Whole Blood Transcriptomic Analysis of Sickle Cell Trait
European Journal of Haematology, Volume 116, Issue 5, Page 535-544, May 2026.ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson +12 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.ABSTRACT Numerous cellular functions, such as apoptosis, proliferation, differentiation, survival, transformation and cell migration, are regulated by a crucial transcription factor called activator protein 1 (AP‐1). Growing evidence indicates that AP‐1 is involved in severe conditions like fibrosis, cancer, and organ damage, as well as inflammatory ...
Maryam Mahjoubin‐Tehran +5 more
wiley +1 more source
Blood Advances, 2017 : The plasminogen activation (PA) system has been implicated in driving inflammatory arthritis, but the precise contribution of PA system components to arthritis pathogenesis remains poorly defined. Here, the role of urokinase plasminogen activator (uPA)
Sherry Thornton +8 more
doaj +1 more source
The Urokinase Receptor (uPAR) as a “Trojan Horse” in Targeted Cancer Therapy: Challenges and Opportunities [PDF]
, 2021 Virginia Metrangolo +2 more
openalex +1 more source
Amiloride inhibits uPAR constitutive uptake in a dose-dependent manner.
, 2013 Panel A. Biotinylation experiments in HEK293-uPAR cells incubated in the absence or presence of amiloride. Lane 1: background, Lane 2: constitutively internalized uPAR, Lane 3: inhibition by amiloride.
Francesco Blasi (61418) +4 more
core +1 more source