Results 111 to 120 of about 14,530 (214)

Combined mRNA expression levels of members of the urokinase plasminogen activator (uPA) system correlate with disease-associated survival of soft-tissue sarcoma patients

BMC Cancer, 2011
Background Members of the urokinase-type plasminogen activator (uPA) system are up-regulated in various solid malignant tumors. High antigen levels of uPA, its inhibitor PAI-1 and its receptor uPAR have recently been shown to be associated with poor ...
Luther Thomas, Eckert Alexander W, Füssel Susanne, Lautenschläger Christine, Bache Matthias, Kappler Matthias, Greither Thomas, Kotzsch Matthias, Magdolen Viktor, Baretton Gustavo, Würl Peter, Taubert Helge   +11 more
doaj   +1 more source

Blockade of diabetes-induced increase in retinal vascular permeability and MMP9 activity in uPAR-/- mice.

, 2013
Diabetic and non-diabetic uPAR-/- mice and their congenic controls (uPAR+/+, uPAR+/-) were injected intravenously with Alexa-Fluor 488-BSA (10 mg/kg) and permeability was quantified as described in the methods section.
Michael W. Brands (442972), Nagla Ghaley (442970), Mohamed Ali Behzadian (442973), Telina Franklin (442969), Ruth B. Caldwell (347665), Azza B. El-Remessy (287151), Jinling Yang (442971)   +6 more
core   +1 more source

uPAR immunohistochemistry in bladder urothelium with inflammation and CIS, respectively.

, 2015
The figure shows examples of uPAR negative benign-appearing urothelium with inflammation (A) and CIS (B). The tissue section was stained with a pAb against uPAR. The antibody was visualised with NovaRed.
Peter Thind (785525), Gunilla Høyer-Hansen (361869), Ole Didrik Laerum (785528), Benedikte Richter Iversen (785523), Martin Illemann (785524), Helle Pappot (785522), Hans von der Maase (785527), Lisbeth Salling (785526), Ib Jarle Christensen (399757), Line Hammer Dohn (785521)   +9 more
core   +1 more source

Urokinase-Rezeptor (uPAR) und Zellkontakte : Mechanismen uPAR-abhängiger Zelladhäsion, Zellmigration und Signaltransduktion

, 2009
Das uPA (Urokinase)-/ uPAR (Urokinaserezeptor)- System ist primär als Fibrinolysesystem bekannt, stellt jedoch zusätzlich ein multifunktionelles System mit einem breitem Einflussspektrum auf inflammatorische Prozesse, Gefäßerkrankungen und Karzinomleiden dar.
Petzinger, Jutta, Justus Liebig University Giessen   +1 more
openaire   +2 more sources

SPRY1 promotes the degradation of uPAR and inhibits uPAR-mediated cell adhesion and proliferation.

American journal of cancer research, 2014
Urokinase plasminogen activator receptor (uPAR) is a GPI anchored cell surface protein that is closely associated with invasion, migration, and metastasis of cancer cells. Many functional extracellular proteins and transmembrane receptors interact with uPAR. However, few studies have examined the association of uPAR with cytoplasm proteins.
Xiufeng, Liu, Yan, Lan, Di, Zhang, Kai, Wang, Yao, Wang, Zi-Chun, Hua   +5 more
openaire   +1 more source

Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells

Biomarker Insights, 2017
The urokinase plasminogen activator receptor (uPAR) has been proposed as a potential prognostic factor for various malignancies. The aim of this study is to assess the prognostic value of uPAR expression in neoplastic and stromal cells of patients with ...
Susanna WL de Geus, Victor M Baart, Martin C Boonstra, Peter JK Kuppen, Hendrica AJM Prevoo, Andrew P Mazar, Bert A Bonsing, Hans Morreau, Cornelis JH van de Velde, Alexander L Vahrmeijer, Cornelis FM Sier   +10 more
doaj   +1 more source

Expression of uPAR^E and uPAR^S in rectal cancer tissue microarray, detected by different epitope-specific MAbs: 3937 (left column) and R4 (right column).

, 2015
Images in rows (i.e., (a) & (b) or (c) & (d) or (e) & (f)) are the same tissue cores from serial sections of the tissue microarray. (a) & (b) represent strong expression of both uPARE and uPARS.
Julie Fletcher (562693), Seong Beom Ahn (562691), Mark S. Baker (562698), Sun Young Kwun (562694), Charles Chan (9232), Candice Clarke (562695), Abidali Mohamedali (562692), Pierre H. Chapuis (562697), Owen F. Dent (562696), Edouard C. Nice (233922)   +9 more
core   +1 more source

Ultrastructural visualization of uPAR endocytic vesicles.

, 2013
HEK293-uPAR cells were incubated with anti-uPAR monoclonal antibody R3 (that recognizes the D1 extracellular domain) at 4°C for 20 minutes, washed and then probed with protein A gold 10 nm in the absence and in the presence of 200 nM RAP. After extensive
Francesco Blasi (61418), Carlo Tacchetti (252415), Katia Cortese (166183), Macarena Sahores (375932), Chris D. Madsen (375934)   +4 more
core   +1 more source

uPAR expression controls cell migration toward serum.

, 2014
uPAR-293 cells (A) or V-293 cells (B) were pre-incubated with nonimmune immunoglobulins (Ig), anti-uPAR or anti-uPAR84–95 polyclonal antibodies, plated in Boyden chambers and allowed to migrate toward 10% FBS.
Nunzia Montuori (511913), Giuseppina Amodio (511911), Pia Ragno (342854), Paolo Remondelli (511912), Anna Li Santi (511910), Daniela Alfano (342853), Anna Gorrasi (511909)   +6 more
core   +1 more source

uPAR-induced cell adhesion and migration: vitronectin provides the key

, 2007
Expression of the membrane receptor uPAR induces profound changes in cell morphology and migration, and its expression correlates with the malignant phenotype of cancers.
Nicolai Sidenius, Gian Maria Sarra Ferraris, Orla Cunningham, Chris D. Madsen, N. Sidenius, G.M. Sarra Ferraris, C. D. Madsen, Annapaola Andolfo, A. Andolfo, O. Cunningham   +9 more
core   +1 more source