Results 111 to 120 of about 14,579 (261)

Prospective phase II trial of prognostication by 68Ga-NOTA-AE105 uPAR PET in patients with neuroendocrine neoplasms: Implications for uPAR targeted therapy

, 2022
The clinical course for patients with neuroendocrine neoplasms (NENs) ranges from indolent to highly aggressive. Non-invasive tools to improve prognostication and guide decisions on treatment are warranted.
Loft, Annika, Berthelsen, Anne Kiil, Carlsen, Esben Andreas, Knigge, Ulrich, Langer, Seppo Wang, Loft, Mathias, Kjaer, Andreas   +6 more
core   +1 more source

table s1 from Molecular Effects of Stromal-Selective Targeting by uPAR-Retargeted Oncolytic Virus in Breast Cancer

, 2023
Yuqi Jing, Valery Chávez, Yuguang Ban, Nicolas Acquavella, Doraya El-Ashry, Alexey Pronin, Xi Chen, Jaime R. Merchan   +7 more
openalex   +1 more source

uPAR is not required for skeletal muscle regeneration

The FASEB Journal, 2006
Muscle regeneration has been shown to be severely impaired in urokinase‐type plasminogen activator deficient (uPA‐/‐) mice, and the impaired regeneration was associated with a lack of macrophage accumulation following muscle injury. Many studies have demonstrated that the receptor for uPA (uPAR) plays an important role in inflammatory cell migration ...
Scott C Bryer, Timothy J Koh
openaire   +1 more source

Prospective phase II trial of [68Ga]Ga-NOTA-AE105 uPAR-PET/MRI in patients with primary gliomas: Prognostic value and Implications for uPAR-targeted Radionuclide Therapy

EJNMMI Research
Background Treatment of patients with low-grade and high-grade gliomas is highly variable due to the large difference in survival expectancy. New non-invasive tools are needed for risk stratification prior to treatment.
Aleena Azam, Sorel Kurbegovic, Esben Andreas Carlsen, Thomas Lund Andersen, Vibeke André Larsen, Ian Law, Jane Skjøth-Rasmussen, Andreas Kjaer   +7 more
doaj   +1 more source

Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells

BMC Cancer, 2010
Background uPAR and MMP-9, which play critical roles in tumor cell invasion, migration and angiogenesis, have been shown to be associated with lipid rafts.
Estes Norman, Gondi Christopher S, Malla Rama, Sodadasu Prasanna, Raghu Hari, Rao Jasti S   +5 more
doaj   +1 more source

Cytoplasmic and membrane staining of uPAR.

, 2014
Representative photomicrographs of tissue microarray sections stained for uPAR, showing typical A) membrane and B) cytoplasmic localized staining of the tumour cells. Scalebar = 50 µm.
Lars Uhlin-Hansen (350451), Elin Hadler-Olsen (593784), Gunbjørg Svineng (593786), Oddveig G. Rikardsen (593783), Synnøve Magnussen (593782), Sonja E. Steigen (593785)   +5 more
core   +1 more source

Data from Increased Plasma Soluble uPAR Level Is a Risk Marker of Respiratory Cancer in Initially Cancer-Free Individuals

, 2023
Anne Langkilde, Tine W. Hansen, Steen Ladelund, Allan Linneberg, Ove Andersen, Steen B. Haugaard, Jørgen Jeppesen, Jesper Eugen‐Olsen   +7 more
openalex   +1 more source

Urokinase-Rezeptor (uPAR) und Zellkontakte : Mechanismen uPAR-abhängiger Zelladhäsion, Zellmigration und Signaltransduktion

, 2009
Das uPA (Urokinase)-/ uPAR (Urokinaserezeptor)- System ist primär als Fibrinolysesystem bekannt, stellt jedoch zusätzlich ein multifunktionelles System mit einem breitem Einflussspektrum auf inflammatorische Prozesse, Gefäßerkrankungen und Karzinomleiden dar.
Petzinger, Jutta, Justus Liebig University Giessen   +1 more
openaire   +2 more sources

Ultrastructural visualization of uPAR endocytic vesicles.

, 2013
HEK293-uPAR cells were incubated with anti-uPAR monoclonal antibody R3 (that recognizes the D1 extracellular domain) at 4°C for 20 minutes, washed and then probed with protein A gold 10 nm in the absence and in the presence of 200 nM RAP. After extensive
Francesco Blasi (61418), Carlo Tacchetti (252415), Katia Cortese (166183), Macarena Sahores (375932), Chris D. Madsen (375934)   +4 more
core   +1 more source

Urokinase Receptor and Resistance to Targeted Anticancer Agents

Frontiers in Pharmacology, 2015
The urokinase receptor/uPAR is a GPI-anchored membrane protein, which regulates protease activity at the cell surface and, in collaboration with a system of co-receptors, triggers cell-signaling and regulates gene expression within the cell.
Steven L. Gonias, Jingjing eHu
doaj   +1 more source